Sciatica
MONDO:0024333A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of sciatic neuropathy; radiculopathy (involving the spinal nerve roots; L4, L5, S1, or S2, often associated with intervertebral disk displacement); or lesions of the cauda equina.
Also known as: bilateral sciatica, bilateral sciaticas, neuralgia, sciatic, neuralgias, sciatic, sciatic Neuralgias, sciatic neuralgia, sciatica, bilateral
65 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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Disc replacement may keep patients working longer than spinal fusion
Disease control CompletedThis study looks at people who received a total lumbar disc prosthesis (Baguera®L) for lower back pain or sciatica caused by disc degeneration or herniation. The goal is to see how many return to their original job five years after surgery. Unlike spinal fusion, which often limit…
Sponsor: University of Valencia • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Can a drug melt away painful scar tissue after back surgery?
Disease control CompletedThis study tested whether a drug that blocks TNF-alpha, a protein involved in inflammation and scar formation, can reduce sciatica pain in people who developed spinal scar tissue after back surgery. 38 adults with persistent pain after discectomy received either the drug or a pla…
Phase: PHASE3 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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Laser test could objectively measure nerve pain for first time
Diagnosis CompletedThis study tested whether a diode laser can act as a biomarker to measure neuropathic pain in people with peripheral neuropathy. Researchers compared pain responses to a lidocaine patch versus a placebo patch in 75 participants. The goal was to see if the laser test could disting…
Phase: NA • Sponsor: University of Utah • Aim: Diagnosis
Last updated Jun 27, 2026 12:09 UTC
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Laser light in veins may ease sciatica and help you sleep
Symptom relief CompletedThis completed pilot study tested whether shining a low-level laser into the blood (intravenous laser therapy) can improve sleep and reduce pain in people with chronic sciatica. Sixty-six adults with sciatica and poor sleep received either electroacupuncture alone or electroacupu…
Phase: NA • Sponsor: Le Hoang Minh Quan • Aim: Symptom relief
Last updated Jul 03, 2026 00:00 UTC
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Tiny camera surgery may beat standard back procedure for faster pain relief
Symptom relief CompletedThis completed study compared two minimally invasive surgeries for herniated discs: full endoscopic lumbar discectomy (FELD) and microdiscectomy (MD). Researchers enrolled 200 adults aged 18-85 with single-level disc herniation and sciatica. The goal was to see which technique pr…
Phase: NA • Sponsor: University of Opole • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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Sugar water shot may ease sciatica pain in ER
Symptom relief CompletedThis study tested whether an ultrasound-guided injection of sugar water around the sciatic nerve could safely reduce sciatica pain in the emergency department. Researchers enrolled 69 adults with acute sciatica and followed up 72 hours later. The goal was to see if the procedure …
Phase: NA • Sponsor: Kaiser Permanente • Aim: Symptom relief
Last updated Jun 27, 2026 12:34 UTC
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Laser or shockwave: which eases piriformis pain best?
Symptom relief CompletedThis study tested two non-drug treatments for piriformis syndrome, a condition where a muscle in the buttock presses on a nerve, causing pain. Seventy adults received either low-level laser therapy or radial shockwave therapy, both combined with exercise, over four weeks. Researc…
Phase: NA • Sponsor: Beni-Suef University • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Which manual therapy eases piriformis pain better? small study pits stretch vs. release
Symptom relief CompletedThis study compared two hands-on treatments—post-facilitation stretch and active release technique—for piriformis syndrome in 40 women aged 25 to 45. Researchers measured pain, disability, quality of life, and hip movement over six weeks. The goal was to see which approach offers…
Phase: NA • Sponsor: Ibadat International University, Islamabad • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Sound waves or needles? small trial pits two piriformis pain fixes Head-to-Head
Symptom relief CompletedThis completed study compared two treatments for piriformis syndrome, a condition causing buttock and leg pain. Forty adults whose pain lasted at least three months were randomly assigned to receive either five sessions of focused sound wave therapy or a single steroid injection.…
Phase: NA • Sponsor: Gulhane Training and Research Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:10 UTC
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Stretching or nerve gliding: which eases sciatica pain better?
Symptom relief CompletedThis study tested two exercise techniques—dynamic stretching and nerve gliding—in 72 adults with lumbar radiculopathy (nerve-related back pain). Both groups also received standard physiotherapy. The goal was to see which approach better reduced pain and improved daily function ov…
Phase: NA • Sponsor: University of Lahore • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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Hands-on therapy showdown: which eases sciatica best?
Symptom relief CompletedThis study tested two physical therapy techniques—nerve gliding exercises and manual muscle release—to see which better relieves sciatica pain. 48 adults with long-term sciatica took part. Researchers measured pain, leg movement, and daily function to find the most effective appr…
Phase: NA • Sponsor: Riphah International University • Aim: Symptom relief
Last updated Jun 27, 2026 12:05 UTC
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Simple hip exercises may ease piriformis pain, small study finds
Symptom relief CompletedThis study looked at whether doing hip abductor strengthening exercises could help people with piriformis syndrome feel less pain and move better. 48 adults with the condition took part. The exercises focused on strengthening muscles that move the leg away from the body. The goal…
Phase: NA • Sponsor: Riphah International University • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Sciatica sufferers: which therapy eases pain better?
Symptom relief CompletedThis study compared two physical therapy techniques—neurodynamic mobilization and Mulligan SNAGs—for people with chronic sciatica caused by a disc problem. 66 participants completed the trial at Cairo University. Researchers measured pain intensity, pressure pain threshold, and l…
Phase: NA • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
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Can special exercises ease piriformis pain? new study investigates
Symptom relief CompletedThis study looked at whether adding a muscle relaxation technique (integrated neuromuscular inhibition) to a standard set of strengthening exercises (McGill program) helps people with piriformis syndrome more than the exercises alone. Fifty-six adults with chronic buttock pain fr…
Phase: NA • Sponsor: Riphah International University • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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Simple back joint maneuver may soothe stubborn hip muscle cramps
Symptom relief CompletedThis study tested whether manually mobilizing the sacroiliac joint (a joint in the lower back) can reduce tension and pain in the piriformis muscle, a deep hip muscle that often cramps. Researchers used physical therapy techniques on 40 adults with lower back or hip pain and musc…
Phase: NA • Sponsor: Charles University, Czech Republic • Aim: Symptom relief
Last updated Jun 27, 2026 08:01 UTC
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Stretching showdown: which technique eases piriformis pain best?
Symptom relief CompletedThis study tested two stretching techniques—Post-Isometric Relaxation and Post-Facilitation Stretching—in 36 adults with piriformis syndrome, a condition that causes buttock pain and limits hip movement. Participants did the exercises three times a week for four weeks. Researcher…
Phase: NA • Sponsor: University of Faisalabad • Aim: Symptom relief
Last updated Jun 27, 2026 08:00 UTC
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Virtual reality offers new hope for chronic back pain sufferers
Symptom relief CompletedThis study tested a virtual reality device to see if it could reduce pain in adults with chronic low back pain that didn't respond to medication. 122 participants used the VR system, which creates a 3D environment with changing colors. The main goal was to measure pain levels aft…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Symptom relief
Last updated Jun 27, 2026 07:58 UTC
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Simple leg stretches may ease back pain from slipped disc
Symptom relief CompletedThis study tested whether adding gentle nerve gliding exercises (called neurodynamic mobilization) to standard physical therapy could help people with a herniated disc in their lower back. Forty adults with confirmed disc herniation and at least 6 weeks of low back pain took part…
Phase: NA • Sponsor: Aydin Adnan Menderes University • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC
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Laser light could ease sciatica pain without surgery
Symptom relief CompletedThis study tested whether high-power laser therapy can reduce pain and disability in people with sciatica caused by a herniated disc. Thirty-six adults with at least 12 weeks of symptoms received either real or sham laser treatments. The goal was to see if the laser improves pain…
Phase: NA • Sponsor: Iran University of Medical Sciences • Aim: Symptom relief
Last updated Jun 26, 2026 17:55 UTC
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Ultrasound reveals muscle differences in hip pain patients
Knowledge-focused CompletedThis study used ultrasound to measure the thickness of certain hip muscles in 60 adults with hip pain on one side (Greater Trochanteric Pain Syndrome) and compared them to healthy people. The goal was to see if muscle thickness differs between the groups and to check for related …
Sponsor: Ankara Etlik City Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Ultrasound may help doctors better diagnose piriformis syndrome
Knowledge-focused CompletedThis study used ultrasound to measure the thickness of the piriformis muscle and sciatic nerve in 19 people with piriformis syndrome, comparing the painful side to the pain-free side. The goal was to see if ultrasound can help tell whether the pain comes more from muscle or nerve…
Sponsor: Istanbul University - Cerrahpasa • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC