Sciatica
MONDO:0024333A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of sciatic neuropathy; radiculopathy (involving the spinal nerve roots; L4, L5, S1, or S2, often associated with intervertebral disk displacement); or lesions of the cauda equina.
Also known as: bilateral sciatica, bilateral sciaticas, neuralgia, sciatic, neuralgias, sciatic, sciatic Neuralgias, sciatic neuralgia, sciatica, bilateral
75 clinical trials for this condition and its sub-types.
Follow this condition to get notified about new trialsSub-types
Broader categories
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Shockwave boost: a new combo for stubborn buttock pain?
Disease control By invitation onlyThis trial compares two non-surgical approaches for deep gluteal syndrome, a condition where the sciatic nerve gets irritated in the buttock area, causing pain and limited movement. About 44 adults aged 25 to 45 will be split into two groups: one receives nerve gliding exercises …
Sponsor: University of Management and Technology Sialkot Pakistan • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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Can adding shockwaves boost bowen therapy for buttock pain?
Symptom relief By invitation onlyThis trial tests whether adding extracorporeal shockwave therapy (ESWT) to the Bowen Technique, a gentle manual therapy, improves outcomes for people with deep gluteal pain syndrome. Forty-six adults aged 25 to 45 with buttock pain will be randomly assigned to receive either Bowe…
Sponsor: University of Management and Technology Sialkot Pakistan • Aim: Symptom relief
Last updated Aug 23, 2026 00:00 UTC
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Massage showdown: which therapy eases piriformis pain best?
Symptom relief By invitation onlyThis study compares two types of hands-on therapy—Stecco Fascial Manipulation and Rolfing Structural Integration—for people with piriformis syndrome, a condition that causes buttock and leg pain. Forty-two adults aged 25 to 45 with at least four weeks of pain will receive four we…
Sponsor: Danyal Ahmad • Aim: Symptom relief
Last updated Aug 14, 2026 00:00 UTC
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New hope for back pain sufferers: no surgery needed?
Symptom relief OngoingThis study looks at whether a non-surgical treatment called spinal decompression can help people with chronic low back pain. About 42 adults with back pain from disc problems or sciatica will receive the treatment over 12 weeks. Researchers will use MRI scans and movement tests t…
Sponsor: University of South Florida • Aim: Symptom relief
Last updated Jun 27, 2026 12:34 UTC
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Can remote rehab beat home workouts for piriformis pain?
Symptom relief By invitation onlyThis study compares two exercise programs—asynchronous telerehabilitation (remote guidance) and a standard home exercise plan—for people with piriformis syndrome, a condition causing buttock and leg pain. About 46 adults aged 18-45 with confirmed diagnosis will participate. The g…
Sponsor: Hacettepe University • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC
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Can herbs and spinal manipulation ease chronic back pain? new study investigates
Symptom relief OngoingThis study looks at whether a combination of herbal medicine and Chuna manual therapy (a Korean spinal manipulation technique) can safely reduce pain and improve walking ability in people with low back pain or sciatica caused by lumbar spinal stenosis or spondylolisthesis. Resear…
Sponsor: Jaseng Medical Foundation • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Simple stretches may ease piriformis pain: new study
Symptom relief OngoingThis study looks at whether adding dynamic stretching to foam rolling helps people with piriformis syndrome more than foam rolling alone. Forty adults aged 35–50 with buttock pain will do either foam rolling or foam rolling plus dynamic stretches for several weeks. Researchers wi…
Sponsor: University of Lahore • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Flat feet may be tied to a common cause of hip pain, study suggests
Knowledge-focused OngoingThis study looks at whether people with flat feet (pes planus) are more likely to have piriformis syndrome, a condition that causes pain in the hip and lower back. Researchers will compare foot posture and pain in adults aged 18-65 who have piriformis syndrome with those who do n…
Sponsor: Kahramanmaras Sutcu Imam University • Aim: Knowledge-focused
Last updated Jul 01, 2026 00:00 UTC