Nasal cavity disorder

This study tests whether an Ayurvedic treatment that targets digestion and gut health can reduce allergy symptoms and immune markers in people with allergic rhinitis (hay fever). 104 adults aged 18-40 with confirmed allergies will receive either the Ayurvedic treatment plus stand…

This study looks at whether taking the drug stapokibart for 4 weeks before sinus surgery helps adults with chronic nasal polyps more than surgery alone. About 48 participants will receive either the drug or a placebo before their operation and be followed for nearly a year. The g…

This early-stage study tests a new drug called cizutamig in about 20 adults with IgE-mediated allergies, including food allergies. The main goal is to see if the drug can safely lower IgE levels, which are antibodies that trigger allergic reactions. Researchers will also monitor …

This study tests a daily dissolving film placed under the tongue to treat dust mite allergic rhinitis (hay fever). About 250 adults in China will use either the active film or a placebo for one year. The goal is to see if the film reduces sneezing, stuffiness, and the need for re…

This early-phase trial is testing whether inhaling tiny particles from stem cells (called small extracellular vesicles) can safely help people with both allergic rhinitis and asthma. About 18 adults will receive either the active treatment or a placebo via nebulizer daily for two…

This study compares two surgical techniques for infants born with choanal atresia, a condition where the nasal passages are blocked. Thirty infants up to 6 years old will receive either a puncture with mitomycin C or a flap technique. The goal is to see which method keeps the air…

This study tests whether AI-powered decision trees can help general practitioners better diagnose and manage allergies. About 600 patients with suspected allergies will be enrolled, and doctors will use an app that suggests next steps based on symptoms. The goal is to see if this…

This study aims to find the best concentration of Blomia tropicalis (a type of dust mite) extract for allergy skin testing. About 30 adults with known dust mite allergies will receive small pricks with different extract strengths to see which causes a reaction similar to a standa…

This study tests whether an injection called stapokibart can reduce nasal allergy symptoms like runny nose, congestion, sneezing, and itching in adolescents aged 12 to 17 with seasonal allergic rhinitis (hay fever). Participants receive either stapokibart or a placebo alongside t…

This phase 2 trial tests the safety of stapokibart injection in 15 teenagers aged 12-17 with seasonal allergic rhinitis (hay fever). Participants receive the drug alongside their usual allergy treatments. The study focuses on side effects and how the body processes the drug, not …

This study looks at how well RHINOSEDAL works for people aged 8 and older with a stuffy nose caused by colds, allergies, or sinus issues. About 126 participants will use the treatment as prescribed and report their symptoms over 6 days. The goal is to see if it provides meaningfu…

This study compares two types of virtual reality (VR) during common ear, nose, and throat (ENT) procedures. One group will watch calming scenery, while the other plays an interactive puzzle game. Researchers want to see which better reduces pain and anxiety. The study will includ…

This study tests if Dymista nasal spray safely eases allergy symptoms like sneezing, stuffy nose, and itchy eyes in Chinese teenagers aged 12 to 17. About 100 participants will use the spray twice daily for two weeks. The goal is to see if symptoms improve, not to cure allergies.

This study tests a new nasal spray called PL-14 Allergy Blocker in about 120 adults with seasonal allergies. Unlike regular allergy sprays, PL-14 is drug-free and works by forming a gel-like barrier in the nose to block allergens. The study compares it to a simple saline spray ov…

This study is testing a special gel made from hyaluronan (a natural substance) to see if it can quickly ease discomfort in the throat and nose for people with chronic rhinitis and pharyngitis. Thirty adults with these conditions will use the gel twice daily for 10 days. The main …

This study tests whether adding moxibustion—a traditional heat therapy—to standard allergy medicine can safely reduce symptoms like sneezing, stuffiness, and runny nose in people with allergic rhinitis. About 60 adults with a cold-type allergy will receive either standard care al…

This study looks at whether removing the adenoids (with or without tonsils) can improve allergy symptoms in children aged 3 to 12 who also have enlarged adenoids and tonsils. Researchers will compare surgery to standard medication by tracking symptom scores and allergy markers in…

This study compares two common treatment combinations for allergic rhinitis (hay fever) in adults: a nasal steroid spray plus an oral antihistamine versus a nasal steroid spray plus an oral antileukotriene. The goal is to see which combo better relieves symptoms like sneezing, st…

This study looks at whether watching cartoons or listening to breath-synchronized interactive stories can help children aged 6-9 feel less afraid and more comfortable while using a nebulizer for breathing medication. About 96 children with respiratory conditions will be randomly …

This study will test the safety of a new biologic drug called stapokibart, given as a shot, in 400 adults with seasonal allergic rhinitis (SAR). Participants are already prescribed the drug by their doctor. The main goal is to track any side effects. This is an open-label study, …

This study tests an injection called JYB1904 for people with year-round allergies (perennial allergic rhinitis). The goal is to see if it can reduce symptoms like runny nose, congestion, and sneezing better than a placebo. About 135 adults who already use nasal sprays will receiv…

This study tests a new medicine called AK139 for people with moderate to severe seasonal allergic rhinitis (hay fever). About 111 adults aged 18-65 with at least a 2-year history of seasonal allergies will receive either AK139 or a placebo. The main goal is to see if AK139 reduce…

This study tests if applying cold (cryotherapy) to the wrist before a blood draw from the artery can reduce pain. It involves 258 adults with chronic respiratory diseases who need this test. The goal is to find a simple, drug-free way to make the procedure less painful.

This study compares two ways to treat moderate to severe allergic rhinitis: using a nasal steroid spray plus an antihistamine nasal spray versus the same steroid spray plus an antihistamine pill. Fifty people aged 12 to 75 will be randomly assigned to one of the two treatments fo…

This study tests whether giving extra booster shots of allergy medicine directly into the tonsils can better control hay fever symptoms. About 276 adults with allergic rhinitis will receive either the standard three doses or additional boosters. Researchers will track symptom rel…

This study looks at how well a saltwater (saline) nasal spray works and how safe it is for infants and toddlers aged 3 months to 4 years with stuffy noses from colds, flu, or allergies. About 83 children will use the spray for up to 14 days, and parents will report symptom change…

This study tests if Acoustic Resonance Therapy (ART) can relieve symptoms of Empty Nose Syndrome (ENS), a condition where past nose surgery leaves patients feeling blocked despite open airways. ART uses sound vibrations to clear mucus and reduce inflammation. About 40 adults with…

This study tests whether adding magnesium sulfate or lidocaine to a standard sedative (dexmedetomidine) better prevents coughing after functional endoscopic sinus surgery. Coughing after this surgery can cause bleeding and slow recovery. About 102 adults will be randomly assigned…

This study tests an injection called GR1802, given alongside usual allergy treatments, to see if it can better control symptoms like sneezing, runny nose, and itchy eyes in people with seasonal allergic rhinitis (hay fever). About 144 adults who have had poor symptom control with…

This study tests whether a natural nasal spray (Puressentiel Allergy Protection) can reduce symptoms of dust mite allergies. Twenty adults with dust mite allergic rhinitis will receive either the spray or a saline placebo before a nasal allergen challenge. Researchers will measur…

This small Phase 2 trial tests whether a single dose of zafirlukast, an asthma drug, can prevent nasal symptoms caused by cat dander. Twelve adults with cat allergies will receive either the drug or a placebo before being exposed to cat dander in a controlled setting. Their sympt…

This study compares two ways to rebuild the nose after partial or total loss: surgery using skin flaps, or a custom-made prosthetic nose (epithesis). Researchers will ask people who had either treatment at least one year ago to fill out a questionnaire about how their nose looks …

This study aims to develop a blood test that measures B regulatory cells, which may indicate whether allergen immunotherapy (allergy shots) is successfully reducing allergic reactions. Researchers will study 80 adults with pollen or venom allergies who are starting routine allerg…

This study looks at chronic sinusitis with nasal polyps, a condition causing long-term nasal congestion and breathing problems. Researchers will measure inflammation markers and examine nasal tissue from 10 adults using a steroid spray (budesonide). The goal is to better understa…

This study looks at whether measuring the thickness (viscosity) of nasal mucus can help doctors better understand the type of inflammation in people with chronic sinusitis and nasal polyps. Researchers will compare mucus from 60 patients having sinus surgery—some with polyps and …

This study uses artificial intelligence to understand how air pollution and climate change impact respiratory diseases like allergic rhinitis and asthma. Researchers will gather health data from about 1,900 patients across Europe and analyze it with AI tools to find better ways t…

This study compares two oral formulations of pranlukast, a drug used for asthma and allergic rhinitis, to see if they are equivalent. Sixty healthy adults will receive a single dose of each version in random order under fasting conditions. The main goal is to measure drug levels …