Myofascial pain syndrome

This phase 3 trial tests whether injecting a concentrate of your own bone marrow (BMAC) into the jaw joint during arthroscopy reduces pain and damage better than a standard steroid shot. Twenty adults with long-lasting TMJ pain will be randomly assigned to one of the two treatmen…

This study tests whether a new Fast Fix suturing system works better than the usual method for repositioning the jaw joint disc in people with TMJ internal derangement. About 50 adults who need surgery after other treatments failed will be randomly assigned to one of the two tech…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This pilot study tests whether focused shockwave therapy can reduce pain and improve function in people with chronic neck and shoulder muscle pain. Sixty adults will be randomly assigned to receive either three weekly shockwave sessions or a home exercise program. Researchers wil…

This study tests whether a gentle neck mobilization technique can improve jaw movement and reduce pain in people with chronic jaw muscle pain (TMD myalgia). 48 adults with jaw pain will receive either the neck treatment or a placebo. Researchers will measure jaw motion, muscle ac…

This study tests whether adding deep breathing exercises to a massage routine can quickly reduce neck pain and stiffness in operating room nurses after surgery. Thirty-eight nurses will receive either massage alone or massage plus breathing exercises in a single session. Research…

This study tests whether shining specific light wavelengths (635, 940, or 1064 nm) on the jaw muscles can reduce pain and improve jaw function in people with chronic jaw muscle disorder (TMD). About 45 adults with moderate-to-severe jaw pain lasting over 3 months will receive sev…

This study tests two different manual therapy techniques—Active Release Technique and Myofascial Release—each paired with eye exercises, to see which better reduces eye strain, improves sleep quality, and lowers stress in people with neck pain. 44 adults aged 18-40 with neck pain…

This study tests whether applying local heat to the jaw can reduce pain and fatigue caused by teeth clenching in people with chronic temporomandibular disorder (TMD). Ten adults with TMD will receive heat therapy and report their pain levels daily for 8 days. Researchers will com…

This study looks at two treatments for a jaw joint condition called disc displacement without reduction, which causes pain and trouble opening the mouth. Fifty-two adults who haven't gotten better with standard care will be randomly assigned to get either arthroscopic surgery alo…

This study tests whether myofascial release therapy, a type of hands-on treatment that loosens tight connective tissue, can improve body posture and facial symmetry in healthy adults. Sixty participants will be randomly assigned to receive the therapy twice a week for six weeks o…

This study tests whether injections of platelet-rich plasma (PRP) can reduce pain and improve jaw function in people with chronic jaw muscle pain (myogenous TMD). Fifty women aged 20–50 with at least 3 months of pain will receive either PRP or a saltwater shot, then be followed f…

This study tests which injection mixture works better for people with a displaced jaw joint (TMJ) that still clicks and moves. Twenty adults will receive either a mix of hyaluronic acid and steroids or hyaluronic acid and platelet-rich plasma after a joint washout. The goal is to…

This study tests two treatments—trigger point activator and shock wave therapy—for people with painful knots in the upper neck muscle. One hundred adults aged 25–40 with active trigger points will be randomly assigned to one of the two therapies. Researchers will measure pain and…

This study tests a hands-on technique called Integrated Neuromuscular Inhibition (INIMT) for people with painful muscle knots in the upper neck. 60 adults with trigger points will receive either INIMT plus standard therapy or standard therapy alone for four weeks. Researchers wil…

This study tests whether tele-rehabilitation—guided video sessions with self-massage, stretches, and posture tips—can reduce pain and improve neck movement in people with rhomboid trigger points. Thirty-six adults with neck and upper back pain will be randomly assigned to either …

This study looks at whether adding sodium bicarbonate (baking soda) to a standard lidocaine injection can provide better pain relief for people with myofascial pain syndrome, a condition causing muscle pain and trigger points. Thirty adults will be randomly assigned to receive ei…

This study tests whether adding dual-task exercises (combining physical movements with mental tasks) to standard physiotherapy, delivered via telerehabilitation, can reduce pain and improve jaw function in young adults with temporomandibular joint (TMJ) dysfunction. Thirty partic…

This study tests whether a stronger laser (high-intensity) works better than a standard low-level laser for reducing pain and improving jaw movement in people with chronic jaw muscle pain. Forty adults will receive 12 laser sessions over one month and be followed for six months. …

This study tests two methods of injecting platelet-rich fibrin (PRF) into the jaw joint for people with a displaced disc that causes pain and limited mouth opening. One method uses ultrasound to guide the needle, the other uses a tiny camera (arthroscope). The goal is to see whic…

This study tests whether combining physiotherapy, structured exercise, and psychological support can reduce the burden of chronic tinnitus (ringing in the ears) in 160 adults aged 18-70. Participants will be randomly assigned to either the 8-week multimodal program or a control g…

This study compares two treatments for buttock pain caused by piriformis syndrome and related muscle pain. Researchers will use ultrasound to guide either a sugar-water injection or a dry needle into the affected area. The goal is to see which method provides better pain relief o…

This study tests whether a special light therapy (photobiomodulation) can reduce pain and improve jaw function in people with myofascial temporomandibular disorder (TMD), a condition causing muscle pain in the face and jaw. About 140 adults will be split into three groups: light …

This study tests three treatments for myofascial pain in the upper trapezius muscle: dry needling alone, dry needling plus a lidocaine injection, and a sham needling plus lidocaine. All groups also do stretching exercises. Ninety adults aged 18–65 with active trigger points will …

This study tests whether a mix of two drugs (triamcinolone and lidocaine) injected into jaw muscle trigger points can reduce pain in people with TMJ disorders. About 30 adults will receive either the active injection or a placebo. The main goal is to see if it lowers pain intensi…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study compares two hands-on treatments—Integrated Neuromuscular Inhibition and Active Release Technique—for people with neck pain caused by trigger points in the upper trapezius muscle. About 64 adults with active trigger points and forward head posture will receive one of t…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study tests whether high-intensity laser therapy can reduce pain and improve neck movement, daily function, and mood in people with trapezius myofascial pain syndrome. About 104 adults with neck pain for at least 4 weeks will receive either real or sham laser treatment. Rese…

This study compares two methods of injecting medicine into the jaw joint to relieve pain and improve function: one using a tiny camera (arthroscopy) and the other using ultrasound guidance. About 50 adults with long-term jaw pain will take part. The goal is to see which approach …

This study compares two needle-based treatments—electrolysis and dry needling—against standard physiotherapy for whiplash pain from car accidents. Thirty-six adults with neck pain and active trigger points will receive one of the three approaches. The goal is to see which method …

This study tests whether adding core-strengthening exercises to standard physical therapy can reduce pain and improve function in people with temporomandibular joint (TMJ) disorders. Fifty adults with jaw pain will be randomly assigned to either standard TMJ therapy or standard t…

This study looks at whether hands-on myofascial release or a tool called Graston can improve flexibility, balance, and agility better than home exercises in people with tight hamstrings. About 45 adults with hamstring shortness will be randomly assigned to one of three groups and…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study aims to better understand and treat myofascial pelvic pain, a common cause of long-term pelvic pain in women. Researchers will use a noninvasive imaging technique to measure pelvic floor muscle function before and after three different treatments: education with relaxa…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study looks at whether a specially trained physical therapist can diagnose jaw disorders (like TMJ) as accurately as an oral surgeon. 70 people with jaw pain will be checked by both a physical therapist and a surgeon, and their diagnoses will be compared. The goal is to see …

This study will observe 300 people with long-term jaw and face muscle pain (TMD) to see how psychological factors relate to their physical symptoms. Participants will fill out questionnaires about their pain and other body symptoms. The goal is to better understand the role of me…

This observational study will measure how well the upper neck moves and how that relates to jaw motion in 50 adults with temporomandibular disorders (TMD). Participants will have their neck and jaw movements measured with simple tools. The goal is to understand if limited neck mo…

This study looks at whether using artificial intelligence (AI) can help physical therapists make better treatment choices for people with myofascial pain syndrome (a type of muscle pain). About 70 adults with chronic muscle pain will be split into two groups: one gets therapy dec…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study checks how often doctors can accurately needle specific hip muscles using only touch and landmarks, without ultrasound guidance. Forty adults with hip pain will receive dry needling, and a second doctor will use ultrasound to see if the needle hit the right spot. The g…