Intestinal obstruction

This completed phase 2 trial tested whether the drug cediranib, given with chemotherapy, is safe for women with advanced ovarian cancer who are at risk of bowel obstruction. 30 participants received the combination. The study focused on whether the treatment caused serious bowel …

This study tested a special collagen mesh (Surgicoll-Mesh) placed in the abdomen during surgery for cancers that have spread to the lining of the belly. The goal was to see if it could prevent serious problems like bowel blockages, infections, or the need for more surgery. 60 adu…

This study tested whether giving prucalopride, a drug used for constipation, before surgery could reduce inflammation and help people recover faster after pancreatic surgery. The idea is that prucalopride might mimic nerve stimulation that calms the immune system. The trial invol…

This study looked at 52 children who needed their colostomy reversed. Half had the stoma closed with full-thickness stitches, the other half with single-layer extramucosal stitches. The goal was to see which method caused fewer leaks or narrowing in the first month after surgery.

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study compares two surgeries—One Anastomosis Gastric Bypass and Duodenojejunostomy—for treating Superior Mesenteric Artery Syndrome (SMAS), a rare condition where the duodenum is compressed, causing severe nausea, vomiting, and weight loss. Twenty participants were randomly …

This completed trial tested a new procedure called percutaneous sigmoid fixation to prevent recurrent sigmoid volvulus (a twisted bowel). The procedure uses an anchor device to fix the colon in place after untwisting it with a scope. The study included 66 high-risk patients aged …

This study tested whether a bedside ultrasound (POCUS) can accurately detect or rule out bowel obstruction in 150 adults with abdominal pain. Doctors performed the ultrasound after a physical exam, then compared results to a CT scan. The goal is to see if this quick, radiation-fr…

This study tested whether putting special elastic tape on the belly can help relieve severe pain, bloating, and nausea in people with advanced cancer who have bowel blockage and fluid buildup. 38 adults whose symptoms didn't improve after standard treatments were randomly assigne…

This study tested whether a structured recovery plan (ERAS) could reduce infections and speed up recovery compared to standard care in 102 adults who had emergency abdominal surgery for a blocked or perforated bowel. Participants were randomly assigned to receive either the ERAS …

This trial investigates whether drinking coffee after pancreatic surgery can help the bowel start working again sooner. About 200 adults who had open pancreatic surgery will receive either regular coffee, decaf coffee, or water twice a day. The main goal is to see how quickly the…

This study tested whether naloxegol, a drug used for constipation caused by painkillers, can help people who had heart surgery recover normal bowel function faster. About 305 adults participated. The goal was to see if taking naloxegol around the time of surgery reduces the time …

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether placing a hot water bag on the abdomen can reduce pain and help restore normal bowel movement in people with ileus (a bowel blockage). Sixty adults with a certain type of ileus took part. Researchers measured pain levels and bowel activity to see if this…

This study looked at whether chewing gum after colorectal surgery can help reduce nausea, vomiting, and get the bowels working again sooner. 84 adults who had laparoscopic colorectal surgery took part. The idea is that chewing tricks the body into thinking it's eating, which may …

This study looked at whether drinking coffee after abdominal surgery can help the bowels start working again sooner. About 174 adults who had surgery were given either regular coffee, decaf coffee, or warm water three times a day. The main goal was to see if a larger study is pos…

This study tested a 12-week nursing program based on the Roy Adaptation Model for adults who recently had a colostomy. It aimed to reduce anxiety and depression and improve quality of life compared to standard care. 115 participants were randomly assigned to either the special pr…

This study tested whether abdominal acupuncture can help women recover normal bowel function faster after gynecologic laparoscopic surgery. 80 women who had a hysterectomy participated. Researchers measured how quickly they passed gas and had their first bowel movement after surg…

This study tested whether adding interactive videos to standard care improves quality of life and recovery in patients with early postoperative bowel obstruction. 462 adults who had abdominal surgery were randomly assigned to either standard care alone or standard care plus a ser…

This study tested whether sugammadex, a drug used to reverse muscle relaxants after surgery, could help patients regain bowel function faster than standard care. 184 adults undergoing open abdominal wall reconstruction for ventral hernia were randomly assigned to receive either s…

This study tested whether chewing gum after abdominal surgery can help the bowels start working again sooner. 128 adults who had bowel surgery and developed a slow gut (postoperative ileus) were asked to chew gum. The goal was to see if the chewing action, which stimulates a key …

This study tested a step-by-step treatment plan called I-MAP for patients who develop a temporary bowel blockage (postoperative ileus) within 30 days after abdominal surgery. The goal was to see if the plan could be used consistently and safely. 60 adults were monitored and treat…

This study tested whether aromatherapy (breathing lavender oil) or acupressure (gentle thumb pressure on specific points) could reduce pain and improve sleep in 100 children aged 6-12 after abdominal surgeries like appendix or hernia repair. The goal was to find simple, non-drug …

This study looked at whether a surgery called STARR, used to treat severe constipation caused by a rectocele or intussusception, affects the anal sphincter's ability to stretch and hold. Nine patients were tested before and 3 months after surgery using a special balloon device (E…

This study looked at how emergency general surgery affects pregnant women and their unborn babies. Researchers planned to follow pregnant women who needed surgery for problems like appendicitis or gallbladder disease. The goal was to learn more about the safety of these surgeries…

This study reviewed the medical records of 504 adults hospitalized with small bowel obstruction to see how using a water-soluble contrast study affected their care. The goal was to find ways to improve patient safety, shorten hospital stays, and reduce complications. Because it i…

This study looked at 90 emergency surgery patients who needed their intestine reconnected. Half had a stapled connection and half had a hand-sewn one. Researchers tracked complications like leaks, infections, bleeding, pain, and hospital stay to see which method worked better.

This study tested whether the Capillary Leak Index (CLI), a score based on routine blood tests, can predict which patients are at higher risk of dying after developing a serious abdominal infection following surgery. Researchers followed 100 critically ill adults in the ICU for 2…

This study looked at the records of 2500 adults admitted to the hospital with serious belly problems like blockages or infections. The goal was to compare outcomes for different treatments, including surgery, keyhole surgery, radiology procedures, and comfort care. By grouping pa…

This completed trial looked at 190 people having laparoscopic appendix removal. It compared closing the appendix stump with a hand-tied knot versus a plastic clip. The goal was to see which method leads to fewer problems like infection or slow bowel recovery within 15 days after …

This completed observational study collected over 3,700 PillCam SB3 capsule endoscopy videos from standard care procedures. The goal was to build a large database of images showing both normal and diseased small intestine tissue. Researchers will use this data to develop and vali…

This study looked at 312 patients who had a small bowel obstruction but had never undergone abdominal surgery. Researchers wanted to find out what caused the blockage and how patients fared over the next five years. By reviewing medical records, they hope to guide better treatmen…