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Could a common gut drug help you heal faster after surgery?

NCT ID NCT02425774

Disease control Sponsor: KU Leuven Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving prucalopride, a drug used for constipation, before surgery could reduce inflammation and help people recover faster after pancreatic surgery. The idea is that prucalopride might mimic nerve stimulation that calms the immune system. The trial involved 31 adults having part or all of their pancreas removed. Researchers measured inflammation in tissues and blood, and tracked how quickly patients passed gas, ate, and had bowel movements.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Prucalopride
What this could lead to
If it works, this could point toward a simple drug treatment to help people recover faster after abdominal surgery.
What could go wrong
This is a very small pilot study with only 31 people, so results may not apply widely. The drug may not reduce inflammation or speed recovery as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

31 people

The number who actually took part.

Start date

Jul 2014

Finished

Feb 2016

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients undergoing partial or full resection of the pancreas due to a benign or malignant tumor Exclusion Criteria: * adjuvant radiotherapy * evident intra-abdominal inflammation (diagnosed by imaging and/or laboratory results, including an abscess or cholecystitis) * chronic pancreatitis * pancreatic polypeptide producing endocrine tumor * American Society of Anesthesiologists physical-health status classification (ASA-PS)\>3 * Poorly regulated diabetes (\>200 mg/dl (=11 mmol/l))

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Conditions

The condition(s) this trial relates to.

paralytic ileus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative ileus

Contacts and locations

Locations

  • University hospitals Leuven

    Leuven, Vlaams-Brabant, 3000, Belgium

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