Infectious encephalitis

This study tests two new mRNA vaccines (GBP560) against Japanese encephalitis, a virus that can cause brain swelling. About 402 healthy adults will receive different doses of the vaccine or a comparison vaccine. Researchers will monitor safety and measure immune responses to find…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …

This phase 2 trial tests the safety of brincidofovir, an antiviral drug, in 24 adults with progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the JC virus. Participants receive the drug intravenously twice a week for up to 12 weeks, with follow-up …

This study tests whether giving patients special donor immune cells (called CD45RA-depleted DLI) can treat viral infections that persist after a stem cell transplant. The trial involves 30 participants who have not improved with standard antiviral drugs. Researchers will measure …

This early-phase study tests whether specially trained immune cells from healthy donors can safely treat viral infections (EBV, CMV, adenovirus, BK virus) in patients who have had a stem cell transplant or certain CAR-T therapy. These infections can be life-threatening when the i…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively control BK and JC virus infections in people with weakened immune systems, such as those with cancer, HIV, or organ transplants. About 100 participants will rec…

This study tests whether the steroid dexamethasone can reduce brain damage in adults hospitalized with tick-borne encephalitis. Researchers will compare disability outcomes in 200 patients who receive either dexamethasone or a placebo. The goal is to see if this treatment lowers …

This study is testing whether immune checkpoint inhibitors, drugs that help the immune system fight infections, can improve outcomes for people with progressive multifocal leukoencephalopathy (PML), a rare brain virus. Researchers will follow 66 patients over a year, measuring di…

This study tests a new treatment for progressive multifocal leukoencephalopathy (PML), a rare brain infection with no approved therapy. Researchers will give 23 patients donor immune cells that target the virus causing PML. The goal is to see if the treatment is safe, improves ne…

This study tests whether specially grown immune cells from an unrelated donor can safely treat viral infections in people with weakened immune systems, such as after a stem cell transplant. About 750 participants will receive these cells and be monitored for side effects like inf…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This study follows 700 people with progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the JC virus. Researchers will collect blood, spinal fluid, and brain scans over time to understand how the disease progresses. No treatment is given; the goal is…

This study aims to discover biological markers (biomarkers) that could help doctors diagnose and track neurological autoimmune diseases such as multiple sclerosis, myasthenia gravis, and Guillain-Barre syndrome. Researchers will analyze samples from 50,000 people, including patie…

This study investigates whether the multiple sclerosis medication ozanimod is linked to a higher risk of progressive multifocal leukoencephalopathy (PML), a rare but serious brain infection caused by the John Cunningham virus. Researchers will review reported cases of PML in peop…

This pilot study tests whether a radioactive tracer called 89Zr-Df-crefmirlimab can help PET scans detect certain immune cells (CD8+ T cells) in the brain and spinal cord of people with multiple sclerosis (MS) or progressive multifocal leukoencephalopathy (PML). About 15 adults w…

This study aims to find blood-based biomarkers that can predict whether a child with acute disseminated encephalomyelitis (ADEM) will experience relapses. Researchers will analyze immune cells from blood samples of 20 children aged 1-18 with a first demyelinating event. The goal …

This study aims to find genetic mutations in the brain that cause drug-resistant epilepsy in children. Researchers will compare DNA from blood and brain tissue, including samples from special electrodes placed in the brain. The goal is to better understand the root causes of thes…

This study aims to better understand autoimmune encephalitis, a condition where the immune system attacks the brain. Researchers will analyze blood and spinal fluid from 20 patients to find new antibodies that may explain the disease in people who currently test negative. The goa…

This study is a registry that collects information from 520 patients diagnosed with central nervous system (CNS) infections, such as meningitis or encephalitis. Researchers will track how many patients survive to discharge. The goal is to better understand these rare but serious …

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study follows 209 children and adults hospitalized with tick-borne encephalitis (TBE) in the Czech Republic for one year after discharge. Researchers track symptoms like fatigue, headaches, memory problems, and weakness to see how long they last and who needs extra support. …

This study is testing whether next-generation sequencing can identify the infectious germs causing severe brain (encephalitis) and spinal cord (myelitis) inflammation in 100 patients in Guadeloupe. Many cases currently have no known cause. By analyzing spinal fluid, researchers h…

This study surveys 100 doctors and trainees in France to assess their knowledge of tick-borne encephalitis, a rare but serious viral infection spread by ticks. The goal is to see if doctors in high-risk areas are more aware than those elsewhere, and to identify gaps that could im…