Infectious disorder of the nervous system

This trial tests a new recombinant polio vaccine (rPV) against the current standard IPOL vaccine in healthy adults aged 18 to 60. The goal is to see if the new vaccine is safe and triggers a strong immune response. It is a small, early-stage study to gather initial data.

This first-in-human study tests a new microneedle patch (Miracus) that dissolves in the skin to deliver a tetanus vaccine without a needle. Thirty healthy adults will receive either an empty patch or one loaded with vaccine. Researchers will check safety, tolerability, and whethe…

This study tests a new vaccine called TdaP2gen in 320 pregnant women in Thailand to see if it safely protects their babies from tetanus, diphtheria, and whooping cough. The vaccine is given during pregnancy, and researchers measure antibody levels in mothers and infants up to 18 …

This early-stage trial is testing a new combination vaccine that protects against whooping cough, diphtheria, and tetanus (Tdap) in people aged 10 and older. Researchers want to see if different doses are safe and trigger an immune response. The study involves 96 volunteers and c…

This study checks if a single rabies booster shot can still protect people who got their first rabies vaccine at least 5 years ago. About 561 healthy adults will get a booster, and researchers will measure their immune response after 7 days. The goal is to see if different initia…

This study tests a new version of the Tdap vaccine (which protects against tetanus, diphtheria, and whooping cough) that has reduced antigens. The goal is to see if it is safe and triggers a strong immune response in people aged 6 and up. Around 660 volunteers will receive either…

This early-stage trial is testing a new vaccine designed to protect against several types of meningococcal bacteria, which can cause meningitis and bloodstream infections. Researchers will enroll 150 healthy people aged 2 to 59 to check the vaccine's safety and how well it trigge…

This study compares two ways of giving the rabies vaccine: the standard shot in the muscle versus a smaller dose injected under the skin. Researchers want to see if the skin method works just as well and is as safe, while using less vaccine and costing less. About 90 healthy volu…

This study tests a new experimental rabies vaccine (ChAdOx2 RabG) given together with the standard rabies vaccine in healthy adults aged 18-45. The goal is to see if this combination is safe and produces a strong immune response, potentially allowing a single visit instead of the…

This trial is testing whether a 10-week course of fluconazole works as well as the standard 24-week course for people with HIV who have a cryptococcal infection in their blood (antigenemia) but no symptoms. It also compares starting HIV medications right away versus waiting 14 da…

This study tests a drug called Sintilimab, which is normally used for cancer, to see if it can help people with HIV who have infections that won't go away with standard treatment. The drug works by 'waking up' exhausted immune cells. Fifty adults with HIV and a hard-to-treat infe…

This study tests a new method of giving antibiotics for moderate-to-severe bacterial meningitis. Instead of only giving antibiotics through a vein, doctors will also inject them into the skull bone to help more medicine reach the brain. The goal is to improve recovery in 86 adult…

This study tests whether efavirenz, a drug used for HIV, can help people with Creutzfeldt-Jakob disease (CJD) live longer. CJD is a rare, rapidly fatal brain disorder. The trial will enroll 246 adults and randomly assign them to receive either efavirenz or a placebo. The main goa…

This study tests a new two-drug combination (Alpibectir and Ethionamide) added to standard treatment for tuberculosis meningitis, a serious brain infection. About 64 adults newly diagnosed with the condition will receive the drugs to see how well they reach the brain and how safe…

This study tests a new antibiotic combination (BV100 plus other drugs) against hard-to-treat infections like pneumonia and bloodstream infections caused by carbapenem-resistant Acinetobacter baumannii. About 120 adults in the hospital will receive either the new combo or the best…

This study will compare two surgical methods for treating fluid collections in the brain that can occur after infant meningitis. One method uses a small camera (neuroendoscope) to remove debris and place a reservoir for drainage. The other is a standard burr hole drainage. The tr…

This study tests whether the antiviral drug aciclovir (or its pill form valacyclovir) works better than a placebo for treating meningitis caused by the herpes simplex virus type 2 (HSV-2). About 150 adults with confirmed HSV-2 meningitis will receive either the drug or a placebo,…

This study aims to create a quick, non-invasive test using saliva to see if someone has enough antibodies to fight tetanus. Instead of drawing blood, a small saliva sample on a test strip would give results in 10-15 minutes. The test is designed for low- and middle-income areas w…

This study looks at whether a quick diagnostic test (BioFire FilmArray) can accurately predict the cause of meningitis or encephalitis in 182 adults. Participants with symptoms like fever, headache, or confusion will have their spinal fluid tested. The goal is to see if the test …

This study tests a new medicine called SNA02-48 to see if it can prevent tetanus in people who have had a high-risk wound, like a deep cut or puncture from a dirty object. About 600 adults will receive either the new injection or the standard treatment (human tetanus immunoglobul…

This study tests whether a short course of the steroid prednisolone can prevent paradoxical immune reconstitution inflammatory syndrome (IRIS) in people with AIDS who have low CD4 counts and are starting HIV treatment. About 131 participants will receive either prednisolone or no…

This study tests a lab-made antibody injection designed to prevent rabies after exposure. About 200 healthy adults aged 18-60 will receive the injection to check its safety and how well it boosts rabies-fighting antibodies. The goal is to find a reliable treatment that can be use…

This study tests whether three different batches of a rabies vaccine work the same way and are safe. It involves 912 healthy adults aged 18 to 45. The goal is to make sure every batch produces a strong immune response.

This early-stage study tests a lab-made antibody called TBE025 in 18 healthy adults aged 18 to 55. The goal is to see if it is safe and how the body processes it when given through a vein. Participants receive one dose and are closely monitored for side effects. This research hel…

This study follows 160 people who previously received a 5-component DTP vaccine (protecting against diphtheria, tetanus, and pertussis) to see how long their immune protection lasts. Blood samples are taken at 2.5, 5, and 10 years after vaccination to measure antibody levels. The…

This study follows 180 children who received a meningitis vaccine (ACYW135 conjugate) years ago to see if their immune protection lasts. Researchers will measure antibody levels in blood samples taken 3 and 5 years after vaccination. The goal is to understand how long immunity pe…

This study follows adults with a family history of genetic prion disease to see how and when the condition first appears. Participants undergo regular check-ins and genetic testing over many years. The goal is to map the natural course of the disease and identify early markers th…

This study will recruit 100 sexual partners of people diagnosed with gonorrhea. Researchers will take an extra throat swab to analyze all the bacteria and their genes using a technique called metagenomics. The goal is to find hidden infections, antibiotic resistance, and see how …

This study will look at balance, core strength, leg strength, walking ability, and fatigue in 32 children aged 6-18 with demyelinating diseases (conditions affecting the protective coating of nerves). Each child will undergo a single session of non-invasive tests like balance exe…

This study aims to find what factors predict recovery in children with acute disseminated encephalomyelitis (ADEM), a rare brain condition. Researchers will follow 25 children aged 6 months to 18 years to see how many recover fully and how many have relapses. The study does not t…

This observational study will follow 50 patients with primary spondylodiscitis, a serious spinal infection, for one year. Researchers will track cure rates, pain levels, and daily function using standard treatments like antibiotics and braces. The goal is to understand how well c…

This study explores whether a blood test can identify the bacteria causing a brain abscess, potentially avoiding the need for brain surgery to get a sample. Researchers will compare the germs found in the blood with those found in the abscess during surgery in 15 adults. If succe…

This observational study will follow 100 children in Denmark who receive a stem cell transplant for blood cancer or other serious blood disorders. Researchers will test their thinking skills, physical abilities, and daily activity before the transplant and for one year after. The…

This study follows 600 Chinese children who received standard vaccines against polio, measles, mumps, rubella, and hepatitis A. Researchers will test their blood to see if protective antibodies remain 5 years after vaccination. The goal is to understand how long vaccine protectio…

This study will compare how well an AI program (Blings) measures speech clarity in 40 adults with speech disorders from stroke or other neurological conditions. Two speech therapists will also rate the same speech samples. The goal is to see if the AI can reliably replace or assi…

This study will follow 32 children diagnosed with their first episode of acute disseminated encephalomyelitis (ADEM), a rare brain inflammation that usually follows an infection. Researchers will check if early MRI scans, spinal fluid tests, and symptoms can predict which childre…

This study will follow 4,000 children in Cambodia to understand how common Japanese Encephalitis (JE) is and how often it spreads without symptoms. Researchers will compare healthy children with those hospitalized for fever and brain-related symptoms. The goal is to measure the t…

This study will follow 175 children and young adults who had a bone marrow transplant before age 18. Researchers will test their thinking, memory, and attention skills, and check for links to physical health issues like metabolism and fitness. The goal is to find early warning si…