Hidradenitis suppurativa

This study tested a drug called sonelokimab, given as a shot under the skin, in 422 adults with moderate to severe hidradenitis suppurativa (a painful skin condition causing boils and abscesses). Participants were randomly assigned to receive either the drug or a placebo for up t…

This study tested a drug called sonelokimab in 418 adults with moderate to severe hidradenitis suppurativa, a skin condition that causes painful lumps and abscesses. Participants received either the drug or a placebo injection for 16 weeks. The goal was to see if sonelokimab redu…

This Phase 3 trial tested bimekizumab, a drug that targets inflammation, in 509 adults with moderate to severe hidradenitis suppurativa (HS), a chronic skin condition causing painful abscesses and tunnels. Participants received either bimekizumab or a placebo over 16 weeks. The m…

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This study tested a drug called bimekizumab in 505 adults with moderate to severe hidradenitis suppurativa, a chronic skin condition that causes painful lumps. The main goal was to see if the drug reduces the number of inflamed lumps by at least half after 16 weeks, compared to a…

This study tested an injectable drug called AVTX-009 in 253 people with moderate to severe hidradenitis suppurativa, a chronic skin condition causing painful lumps. Participants received either the drug or a placebo every 2 or 4 weeks. The goal was to see if the drug could reduce…

This phase 3 trial tested the drug povorcitinib in 608 people with moderate to severe hidradenitis suppurativa, a chronic skin condition causing painful lumps and abscesses. Participants received either the drug or a placebo for 12 weeks, followed by a 42-week extension where eve…

This phase 2 study tested a new drug called SAR442970 in 86 adults with moderate to severe hidradenitis suppurativa, a chronic skin condition causing painful lumps. The drug is a Nanobody that targets two inflammatory proteins. Researchers compared it to a placebo to see if it co…

This phase 3 trial tested an oral drug called povorcitinib in 619 adults with moderate to severe hidradenitis suppurativa, a chronic skin condition causing painful abscesses. Participants received either the drug or a placebo for 12 weeks, followed by a 42-week extension. The mai…

This study tested an experimental drug called ATI-450 in 95 people with moderate to severe hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps. The goal was to see if the drug reduces the number of abscesses and inflamed nodules compared to a placebo ove…

This study tested whether tofacitinib, a drug already approved for arthritis, is safe and helpful for immune-related skin conditions in people with Down syndrome. 47 adolescents and adults with Down syndrome and skin issues like eczema or psoriasis took the drug. Researchers chec…

This study looked at the long-term safety and effectiveness of the drug spesolimab for adults with hidradenitis suppurativa (HS), a painful skin condition. Participants who had already completed a previous spesolimab trial received injections every two weeks for two years. The go…

This study tested whether spesolimab, a drug already approved for another skin condition, can help people with moderate to severe hidradenitis suppurativa (HS), a painful skin disease that causes abscesses and tunnels. 209 adults participated, receiving either spesolimab or a pla…

This study tested whether spesolimab, an anti-inflammatory drug, can reduce painful lumps and abscesses in adults with moderate to severe hidradenitis suppurativa. Fifty-two participants were randomly assigned to receive either spesolimab or a placebo for about 3 months. Doctors …

This phase 2 trial tested a drug called imsidolimab (ANB019) in 149 people with hidradenitis suppurativa, a chronic skin condition causing painful abscesses and nodules. Participants received either the drug or a placebo to see if it could reduce the number of inflamed lesions. T…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested whether an artificial intelligence (AI) tool could help primary care doctors diagnose skin conditions more accurately. Nine doctors reviewed 30 images of various skin problems, first giving their own diagnosis and then a final diagnosis after seeing the AI's sug…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration form of adalimumab (AVT-02). Researchers measured injection site pain and how well patients stuck with their treatment over 180 days…

This study tested whether a special bioelectric dressing can improve healing after a surgical procedure called de-roofing for hidradenitis suppurativa (HS), a chronic skin condition. Twelve adults with HS had two wounds treated: one with the bioelectric dressing and one with stan…

This small study tested a combination wound dressing for people with hidradenitis suppurativa (HS) who have non-healing wounds or draining abscesses. The dressing contains methylene blue, gentian violet, and a sheep stomach-derived material. Five adults were followed for 8 weeks …

This study tested whether a 6-week online mindfulness course could improve quality of life for people with hidradenitis suppurativa (HS), a chronic skin condition that causes painful boils. Thirty-seven adults with HS took part. Half attended weekly mindfulness classes and did gu…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study tested whether an artificial intelligence (AI) tool could help doctors diagnose rare and tricky skin conditions like generalized pustular psoriasis (GPP). Fifteen doctors, including both general practitioners and dermatologists, looked at 100 skin images. They first ga…

This study looked at skin samples from 20 people with hidradenitis suppurativa (HS) who had surgery. Researchers measured different inflammatory proteins in the lab to understand what drives the disease. The goal was to learn more about how inflammation works in HS, not to test a…

This study tested an artificial intelligence algorithm designed to help primary care doctors decide whether a patient with a skin condition really needs to see a dermatologist. Researchers enrolled 200 adults with skin problems and had their doctors take photos of the affected ar…

This completed study checked the gum health of 226 adults with hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps. Researchers measured gum pockets, bleeding, and plaque, and compared them to healthy people. The goal was to see if HS inflammation might …

This study examined skin samples from 15 people with hidradenitis suppurativa (HS) and 15 healthy volunteers to measure certain genes and proteins linked to inflammation. The goal was to better understand what causes HS and find possible markers of disease severity. No treatment …

This study surveyed 67 adults with hidradenitis suppurativa (HS) to better understand how the condition affects their quality of life. Researchers also tested a new tool that lets patients rate their own disease severity using photos. The goal is to improve how doctors and patien…