Head injury
MONDO:0800482An injury that involves the head.
110 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Battlefield plasma goes civil: can a powder save trauma victims?
Disease control CompletedThis study tested a freeze-dried plasma product that can be mixed with water in 6 minutes, avoiding the long thaw time of standard plasma. It included 42 trauma patients with severe bleeding who needed blood transfusions. The goal was to see if faster plasma delivery could improv…
Phase: PHASE3 • Sponsor: University Hospital, Lille • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New study tests best emergency breathing tube for trauma victims
Disease control CompletedThis study looked at over 2,000 trauma patients who needed help breathing before arriving at the hospital. Half were given a supraglottic airway device (like an LMA or King tube) first, while the other half received standard care. The goal was to see which approach led to more pa…
Phase: NA • Sponsor: Jason Sperry • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New monitoring method may cut pneumonia risk in ventilated patients
Disease control CompletedThis study tested whether continuously monitoring the pressure in the breathing tube cuff (using a ventilator system) could reduce pneumonia compared to manual checks every 8 hours. It involved 40 ICU patients with severe head injury who needed a breathing machine. The goal was t…
Sponsor: University Medical Centre Ljubljana • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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Checklist could be lifesaver for trauma patients
Disease control CompletedThis study tested whether using the World Health Organization's trauma care checklist helps injured patients recover better. Sixty adults with trauma were randomly assigned to standard care or care with the checklist. Researchers measured pain, injury severity, complications, and…
Phase: NA • Sponsor: Khyber Teaching Hospital • Aim: Disease control
Last updated Jun 26, 2026 18:46 UTC
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New rapid test for infection and inflammation put to the test
Diagnosis CompletedThis study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…
Sponsor: LumiraDx UK Limited • Aim: Diagnosis
Last updated Jun 27, 2026 13:07 UTC
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Could a quick ultrasound replace CT scans for Kids' skull fractures?
Diagnosis CompletedThis study tested whether a bedside ultrasound (POCUS) can accurately detect skull fractures in children aged 2-18 with mild closed head injuries. Researchers enrolled 95 children in the emergency department and compared ultrasound results to CT scans. If effective, this approach…
Sponsor: Assiut University • Aim: Diagnosis
Last updated Jun 27, 2026 13:00 UTC
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Pocket-Sized scanner could spot brain bleeds in remote areas
Diagnosis CompletedThis study tested a handheld device that uses near-infrared light to quickly detect bleeding inside the skull after a head injury. Researchers compared the device's results to CT scans in 180 patients in Uganda. The goal was to see if this portable tool could help diagnose brain …
Phase: NA • Sponsor: Duke University • Aim: Diagnosis
Last updated Jun 27, 2026 09:08 UTC
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New CT imaging algorithm matches current standard in quality study
Diagnosis CompletedThis study tested a new image-processing algorithm called Spectral Precise Image (SPI) on a CT scanner. Researchers compared the image quality and diagnostic confidence of SPI against the standard iDose4 method in 126 adults undergoing head, body, or cardiac scans. The goal was t…
Sponsor: Philips Clinical & Medical Affairs Global • Aim: Diagnosis
Last updated Jun 27, 2026 08:04 UTC
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Can High-Tech goggles spot concussions in the ER?
Diagnosis CompletedThis study tested whether a portable goggle system with eye-tracking technology can accurately diagnose mild traumatic brain injury (mTBI) in community settings like emergency rooms. Researchers enrolled 120 adults aged 18-50 who had a head injury with symptoms. The goal was to s…
Phase: NA • Sponsor: University of Miami • Aim: Diagnosis
Last updated Jun 26, 2026 12:37 UTC
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Robot buddy calms kids during bandage changes
Symptom relief CompletedThis study tested whether a social robot could reduce fear and pain in children aged 5 to 10 during wound dressing. Sixty children were split into two groups: one interacted with the robot while getting their wound dressed, and the other received standard care. Researchers measur…
Phase: NA • Sponsor: Ondokuz Mayıs University • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Ketamine may cut opioid needs for trauma patients
Symptom relief CompletedThis study looked at whether giving a low dose of ketamine continuously could lower the amount of strong painkillers (opioids) needed by people with serious injuries. The goal was to see at least a 25% reduction in opioid use over 48 hours while still controlling pain just as wel…
Phase: PHASE3 • Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Symptom relief
Last updated Jun 27, 2026 09:01 UTC
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Paws for recovery: therapy dogs get trauma patients moving
Symptom relief CompletedThis study looked at whether walking with a therapy dog helps adult trauma patients move more during their hospital stay. Sixty-four patients each took two walks—one with a dog and one without—and reported their pain, anxiety, and motivation. The goal was to see if animal-assiste…
Phase: NA • Sponsor: Andrew Bernard • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
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Dancing to better health: new study tests remote exercise for disabilities
Symptom relief CompletedThis study tested a 12-week exercise program set to music for adults with physical disabilities like spinal cord injury, stroke, or Parkinson's disease. Participants exercised three times a week via video calls, doing movements adapted to their ability. The goal was to see if the…
Phase: NA • Sponsor: University of Alabama at Birmingham • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC
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New rule could help emergency dispatchers spot hidden brain bleeds in elderly fall victims
Knowledge-focused CompletedThis study aims to create a simple rule that emergency call handlers can use to predict whether an older adult (65+) who has fallen and hit their head is at risk of a brain bleed. Researchers will collect information from 1,100 calls to the SAMU emergency center in Toulouse, Fran…
Sponsor: University Hospital, Toulouse • Aim: Knowledge-focused
Last updated Jul 01, 2026 00:00 UTC
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New score could save lives of motorcycle crash victims
Knowledge-focused CompletedThis study aims to create a simple bedside tool that helps doctors quickly identify motorcycle accident victims with chest injuries who are at high risk of dying. Researchers will analyze data from 1250 patients to build and test the tool, focusing on factors like helmet use and …
Sponsor: Antalya Health Sciences University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Do trauma patients really need that Full-Body scan?
Knowledge-focused CompletedThis completed study looked at 510 trauma patients who had no signs of nerve damage. Researchers wanted to see if getting a full-body CT scan actually changed how doctors managed their care. The goal is to find out if these scans are truly helpful or just add cost and time.
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Tourniquets before hospital: help or hype?
Knowledge-focused CompletedThis study looked at 55 adults with arm or leg injuries to see if using a tourniquet before reaching the hospital made a difference. Researchers compared those who had a tourniquet placed to those who did not, checking for shock, blood transfusions, and other complications. The g…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Golden hour under the microscope: trauma care timing studied
Knowledge-focused CompletedThis study looked at 265 severely injured adults in France to see if getting them to the hospital within the recommended 60 minutes (the 'golden hour') improves their chances of survival. Researchers checked if following these time guidelines helped patients live at least 24 hour…
Sponsor: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Fall risk calculator could save lives by predicting who needs urgent care
Knowledge-focused CompletedResearchers looked at records from over 58,000 adults who had fall injuries to build a simple scoring system that estimates the chance of dying within 30 days. The tool uses age, sex, and vital signs taken in the emergency room. This study did not test any treatment—it only aimed…
Sponsor: Mackay Memorial Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Can tailored shakes help seniors bounce back from trauma?
Knowledge-focused CompletedThis pilot study tested whether a personalized nutrition plan using up to three Ensure shakes a day is practical for older adults (60+) recovering from a serious injury. Forty participants were randomly assigned to either the nutrition plan or standard care. The study did not mea…
Phase: NA • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Blood transfusion trends in trauma: what worked and what Didn't?
Knowledge-focused CompletedThis study looked back at the medical records of 137 severely injured trauma patients who needed large blood transfusions between 2020 and 2025. Researchers analyzed how different transfusion strategies, such as balanced ratios and whole blood use, affected 30-day survival and ot…
Sponsor: Mariah Arif • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Parents' hidden trauma after Child's ICU stay revealed
Knowledge-focused CompletedThis study looked at how parents cope emotionally after their child is hospitalized in intensive care for a severe injury. Researchers checked for signs of anxiety, depression, and post-traumatic stress in 62 parents, 3 to 6 months after the child left the ICU. The goal was to un…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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Frailty index may predict trauma outcomes in seniors
Knowledge-focused CompletedThis study tested a simple frailty score (TSFI) to see if it can predict complications and death in trauma patients aged 65 and older. Researchers enrolled 500 patients across multiple hospitals. The goal was to improve care by identifying high-risk patients early, not to provide…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Obesity's impact on hospital stays for seniors after injury examined
Knowledge-focused CompletedThis study looked at how obesity affects the hospital course and outcomes of trauma patients aged 60 and older. Researchers compared obese and non-obese patients to see if obesity leads to longer stays, more complications, or higher costs. The goal was to clarify conflicting repo…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Organized trauma networks may cut deaths after severe injury
Knowledge-focused CompletedThis study looked at whether a structured regional health system, where trauma centers are organized by level of care, reduces deaths within 28 days after severe injury. Researchers compared outcomes for 2193 severely injured patients treated in a structured system versus a non-s…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Can a simple score predict who lives after trauma? new study tests it in iraq
Knowledge-focused CompletedThis study checked how well the Trauma and Injury Severity Score (TRISS) predicts survival and the need for intensive care or surgery in 204 trauma patients at one hospital in Iraq. Researchers measured the score within 6 hours of arrival and tracked outcomes. The goal is to see …
Sponsor: Al-Nahrain University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Arm surgery nerve block study also checks eye pressure
Knowledge-focused CompletedThis study looked at how different amounts of numbing medicine given around the collarbone affect pain relief and side effects during arm surgery. Researchers also used ultrasound to measure the nerve behind the eye to see if it relates to brain pressure. 64 patients aged 18 to 5…
Phase: NA • Sponsor: Pamukkale University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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Smarter scans: new score could slash unnecessary radiation in kids with trauma
Knowledge-focused CompletedResearchers studied 407 children under 18 who had whole-body CT scans after trauma. They looked at injury details, physical exams, and lab results to create a scoring system called WHOLE. The goal is to help emergency doctors decide when a full-body scan is truly needed, reducing…
Sponsor: Ankara City Hospital Bilkent • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Severe trauma and clotting: new study reveals hidden risks
Knowledge-focused CompletedThis study looked at 263 severely injured trauma patients to find out how often they develop early blood clotting problems (called trauma-induced coagulopathy) and excessive clot breakdown (hyperfibrinolysis) within the first hour of arriving at the emergency room. Researchers us…
Sponsor: Medical University of Graz • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Ultrasound may make emergency catheter placement safer for trauma patients
Knowledge-focused CompletedThis study tested whether using ultrasound to guide the placement of catheters in the femoral artery and vein (in the groin) reduces complications in severely injured patients in the intensive care unit. The trial involved 136 adults with severe trauma who needed these catheters.…
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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New electrode method could spot hidden brain damage early
Knowledge-focused CompletedThis study tested whether implanting special electrodes on the brain's surface can safely detect spreading depolarizations—electrical waves that may signal new damage after severe head trauma or brain hemorrhage. Twenty patients in intensive care received these electrodes alongsi…
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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New rule could spare thousands of infants from unnecessary brain scans
Knowledge-focused CompletedThis study looked at over 8,800 infants under 2 years old who came to the emergency room with a minor head injury. Researchers wanted to see if a special checklist (the PELICAN rule) could help doctors decide when a CT scan is truly needed. The goal is to avoid unnecessary radiat…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Massive study reveals how neck and facial bleeding affects trauma victims
Knowledge-focused CompletedThis study looked at 15,000 trauma patients treated at a Swedish hospital over 10 years. Researchers focused on those with serious neck or face injuries to understand what causes deadly bleeding and how it is managed. The goal is to improve care for future patients with these inj…
Sponsor: Karolinska University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC
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Can a catheter in bone tell surgeons if a graft is healthy?
Knowledge-focused CompletedThis study tested whether a small microdialysis catheter placed directly into a bone graft could monitor blood flow and healing after head and neck reconstruction. Thirty-four people having surgery with bone from their hip or leg took part. The goal was to see if the catheter cou…
Phase: NA • Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:15 UTC
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Timing of palliative care for kids with brain disease under review
Knowledge-focused CompletedThis study looked at 126 children and young adults (up to age 25) with serious, non-progressive neurological diseases like cerebral palsy or brain injury. Researchers wanted to understand the best time to introduce a pediatric palliative care team. They reviewed medical records f…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:36 UTC