Focal epilepsy

This study tests whether a daily pill called BHV-7000 can reduce seizures in adults with refractory focal epilepsy—a type of epilepsy that doesn't respond well to current medications. About 390 participants will receive either a low dose, a higher dose, or a placebo for 8 weeks. …

This study tests whether adding perampanel (Fycompa) to current epilepsy medications can reduce seizures in children aged 1 month to 18 years. About 100 children with specific epilepsy syndromes or partial-onset seizures will receive the drug. The main goal is to see if at least …

This study follows 158 people in France who are prescribed Epidyolex (a cannabidiol-based medicine) for seizures as part of their normal care. Researchers will track how long people stay on the treatment, side effects, seizure frequency, and changes in daily functioning and quali…

This early-phase study tested a new drug called BHV-7000 in 5 people with epilepsy who have a brain implant (RNS) that records brain activity. The goal was to see if the drug reduces abnormal electrical activity linked to seizures. Participants took the drug for 4 weeks, and thei…

This study tests the long-term safety and effectiveness of XEN1101 (azetukalner) in 880 adults with focal or tonic-clonic seizures. Participants who completed earlier studies will take XEN1101 capsules for up to 6 years. Researchers will track side effects and changes in monthly …

This study checks the long-term safety of the drug BHV-7000 in about 660 adults whose focal epilepsy has not been controlled by other treatments. Participants who completed an earlier study will continue taking the drug while doctors watch for side effects and lab changes. The go…

This phase 3 trial is testing the safety and tolerability of the drug cenobamate (Xcopri) in 140 children aged 2 to 17 with partial-onset (focal) seizures. Researchers will monitor side effects, lab results, and drug levels in the blood. The study is open-label, meaning everyone …

This study tests whether cenobamate, already approved for epilepsy, works well when used alone in adults with partial-onset seizures. About 49 participants will take either 100 mg or 200 mg daily, and researchers will track how many become seizure-free for 26 weeks. The goal is t…

This study is testing the long-term safety of a once-daily drug called vormatrigine in 700 adults with focal or generalized tonic-clonic seizures. Participants must have already taken vormatrigine in a previous trial or program. The main goal is to check for side effects and chan…

This pilot study tests whether deep brain stimulation (DBS) of a brain region called the subiculum can safely reduce seizures in 6 people with drug-resistant temporal lobe epilepsy and bilateral hippocampal sclerosis. Participants receive a DBS device, and researchers track seizu…

This program provides continued access to the seizure medication perampanel (Fycompa) for people who completed certain earlier studies and are still benefiting from the drug. It runs until the drug is commercially available in their country or no participants remain. Only those a…

This study looks at how well the drug cenobamate works for adults with focal seizures that don't improve with at least two other epilepsy medicines. Researchers are collecting data from Italian clinics and a compassionate use program to measure seizure reduction and side effects.…

This study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…

This small study tested whether a non-invasive brain stimulation technique called tDCS can be used safely at home to reduce seizures in people with epilepsy. Four adults with hard-to-control seizures used the device daily for several weeks. Researchers tracked seizure counts, sev…

This small study tests whether low-intensity focused ultrasound (LIFU) can safely reduce seizures in people with temporal lobe epilepsy that doesn't improve with medication. Six participants with implanted brain electrodes will receive both real and sham ultrasound sessions. The …

This study tests a pair of smart glasses called NEXA that can read brain signals through dry electrodes. The glasses aim to predict epileptic seizures in real time and alert the wearer with vibrations, lights, or sounds. Researchers will test the device on 47 adults with epilepsy…

This study looked at how sounds played during sleep affect brain waves and memory in children with Rolandic epilepsy. Researchers used brain scans (MRI, MEG/EEG) to understand which brain circuits are involved. The goal was to find new treatment ideas for this type of childhood e…

This study looks at gene activity in brain tissue removed during surgery from 10 people with temporal lobe epilepsy and hippocampal sclerosis. The goal is to find which genes are linked to the disease and may help predict outcomes. No new treatment is being tested; instead, resea…

This study tests a brain implant that records brain activity and can deliver small electrical pulses to prevent seizures in people with epilepsy. Five participants will use the device along with a handheld tool to track mood, anxiety, and thinking. The main goal is to see if the …

This early-stage trial tests the safety of an experimental oral drug called iQ-007 in 72 healthy volunteers. The drug is designed to help control seizures by boosting the brain's ability to clear excess glutamate, a chemical linked to epilepsy. The study does not yet test if it w…

This pilot study at the University of Chicago is testing whether a non-invasive brain stimulation technique called TMS can improve memory and reduce seizure-related brain activity in people with mesial temporal lobe epilepsy (MTLE). Thirty-four adults with drug-resistant MTLE wil…

This study planned to test a wearable device called EpiCare@Home that records brain activity, heart rate, and movement to detect focal seizures. It was designed for people with epilepsy, both in the hospital and at home. However, the study was withdrawn before enrolling any parti…

This study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…