Brain zaps for seizures: tiny trial tests new target
NCT ID NCT06436547
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tests whether deep brain stimulation (DBS) of a brain region called the subiculum can safely reduce seizures in 6 people with drug-resistant temporal lobe epilepsy and bilateral hippocampal sclerosis. Participants receive a DBS device, and researchers track seizure frequency and quality of life over time. The goal is to see if this approach works for those who cannot have standard surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- deep brain stimulation (DBS) device targeting the subiculum
- What this could lead to
- If it works, this could offer a new treatment option for people with drug-resistant epilepsy who cannot have surgery.
- What could go wrong
- This is a very small pilot trial with only 6 participants, so results may not apply widely. The procedure carries surgical risks, and the long-term benefits are uncertain.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Xuanwu Hospital,Capital Medical University
Beijing, Beijing Municipality, 100053, China
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Other studies related to the condition(s) this trial covers.