Focal epilepsy

This study tested a brain implant (deep brain stimulation) to reduce seizures in 29 adults with epilepsy whose seizures were not controlled by medication. Participants kept diaries to track seizure frequency over three years. The goal was to see if the device safely and effective…

This study looked at the long-term safety of an experimental drug called CVL-865 in adults whose focal seizures were not controlled by other medications. About 105 people who completed a previous trial took CVL-865 alongside their usual seizure drugs for up to 57 weeks. The study…

This study compares two treatments for transformed migraine (chronic daily headache): a sphenopalatine ganglion nerve block using lidocaine gel applied inside the nose, versus daily oral amitriptyline (Elavil), an antidepressant often used for migraine prevention. Ten adults aged…

This study looked at how a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) changes brain activity in people with hard-to-treat frontal lobe epilepsy. Researchers measured brain excitability before and after stimulation to unders…

This study tested a small device implanted under the scalp to record brain waves (EEG) continuously for up to 12 weeks in people with epilepsy. The goal was to see if it could detect seizures better than standard short-term hospital monitoring and patient diaries. The trial invol…