Dysthymic disorder

This study tested whether levodopa, a drug used for Parkinson's disease, can improve thinking speed, walking, and mood in older adults with depression. Researchers gave 79 participants either levodopa or a placebo for three weeks. The goal was to see if boosting dopamine could he…

This study tests a new behavioral therapy called OPT-A for teenagers who have both substance use problems and mood or anxiety disorders. 140 teens aged 10-17 will receive either OPT-A or standard treatment. Researchers will track substance use and mental health for 18 months to s…

This study tested whether a smartphone app designed for people with serious mental illness can help them quit smoking better than standard methods. Researchers enrolled 343 adults with conditions like bipolar disorder or schizophrenia who wanted to quit. Participants used either …

This study tested whether personalized, intensive nursing follow-up (by phone, home visits, or hospital consultations) after a suicide attempt could prevent another attempt or crisis in people with mood disorders. 380 participants were followed for one year. The goal was to see i…

This study tested a 10-week program called the Protecting Families Program (PFP) for depressed parents and their pre-teen children. The goal was to see if the program could prevent depression in the children. 42 families took part, with parents in treatment for depression. The pr…

This study tests a therapy called the Unified Protocol, designed to help people with emotional disorders like anxiety and depression by improving emotional regulation. Researchers compare delivering the therapy in online group sessions versus in-person group sessions to see if bo…

This study investigates how avoidance behaviors contribute to depression and anxiety in teenagers, and tests a group therapy called Group Behavioral Activation Therapy (GBAT). The therapy involves 15 weekly sessions teaching skills to understand and change avoidance patterns. Res…

This study tested an online group program called Healthy Minds for people on sick leave due to depression, anxiety, or adjustment disorders. 123 participants either joined the 8-week program or received standard care. Researchers tracked their return to work, symptoms, and job fu…

This study tested whether a gentle electrical current applied to the scalp (tDCS) could make computer-based brain training more effective for older adults with recurrent depression. Sixteen people aged 60 and older took part. The goal was to see if this combination improved memor…

This study tested whether a 4-month gym exercise program helps young adults (18-35) taking antipsychotic medication for psychosis or mood disorders feel better in their daily lives. 226 participants were randomly assigned to either continue their usual care or add gym workouts. R…

This study tested an internet-based cognitive behavioral therapy (CBT) program called AMTE for adolescents with anxiety and depression. Sixty teens were randomly assigned to either the online program or a control group. The goal was to see if the program could reduce symptoms of …

This study tested whether pramipexole, a drug used for Parkinson's disease, can help people with depression who still have trouble feeling pleasure or motivation despite taking standard antidepressants. 85 adults with depression and significant anhedonia took either pramipexole o…

This study looked at whether adding pramipexole (a drug used for Parkinson's) for 6 months can safely reduce anhedonia — the loss of pleasure or interest — in people with depression. 55 adults who had already been in a shorter trial took pramipexole alongside their usual treatmen…

This study tested a digital mental health program for adults with depressive symptoms. The program includes nine online modules covering topics like positive thinking, relaxation, and healthy habits. Researchers compared results between people with diagnosed mood disorders and th…

This study tested whether taking part in art activities like theatre, dance, visual arts, music, or cinema can improve mental health. 541 adults with psychiatric diagnoses were randomly assigned to either an art program or a waitlist. Researchers measured changes in depression an…

This pilot study tested whether pramipexole, a drug used for Parkinson's disease, could help people with depression who struggle with anhedonia—the inability to feel pleasure or motivation. Thirteen adults with depression and significant anhedonia took pramipexole alongside their…

This study tested a new 8-session psychotherapy called ChronoS in 67 adults with mood disorders (bipolar or depression) and chronic insomnia. The therapy focuses on sleep-wake awareness and habits. Researchers measured changes in insomnia severity using a standard questionnaire. …

This study looks at how transcranial magnetic stimulation (TMS) affects a brain area called the subgenual cingulate, which is linked to depression. Researchers will give 54 adults with depression daily TMS sessions for 4-6 weeks, along with MRI scans, to see how this brain region…

This study investigates what makes cognitive-behavioral therapy effective for children and teens aged 7 to 16 with anxiety or depression. Researchers will analyze therapy sessions and outcomes to identify which techniques and processes lead to improvement. The goal is to understa…

This study used MRI brain scans and computer tasks to understand how people who attempted suicide make decisions. Researchers compared three groups: those who used violent means, those who used non-violent means, and healthy volunteers. The goal was to find brain activity pattern…

This study tested whether a smartphone app that tracks how you type (speed, backspace use, autocorrect) can help monitor mood and thinking problems in people with mood disorders like depression or bipolar disorder. 132 adults aged 25-50 took part. The goal was to see if this simp…

This study tested whether sending outreach messages (via secure messaging or phone) to people from racial and ethnic minority groups could help them start depression treatment after a new diagnosis. The study included 309 adults who had not started treatment within 30 days of dia…

This study looked at whether schema therapy, a type of talk therapy, could help people with depression that hasn't gotten better with usual treatments. Two participants received 30 therapy sessions over about a year. The goal was to see if this approach is feasible and to learn h…

This study examined 24 adolescents (ages 14-18) with and without depression to see if their brains respond differently to insulin. Participants received insulin or a placebo nasal spray, and MRI scans measured brain activity and blood flow. The goal was to understand if brain ins…

This study tested a program called IPS-MA, which helps people with mood or anxiety disorders find and keep jobs or return to school. 326 adults who were unable to work within three months took part. The goal was to see if this support, added to their usual treatment, helped them …

This study looked at 48 adults with mood disorders and insomnia to see if a strong relationship with their therapist helped them get better results from a new type of therapy called ChronoS. The therapy combines sleep scheduling, mindfulness, and stress management. Researchers me…