Coronary thrombosis

This trial tests whether a new device called SynFlow 3.0 can safely support the heart during high-risk angioplasty (a procedure to open blocked coronary arteries) as well as the standard VA-ECMO device. About 222 people with severe coronary artery disease and a weakened heart (ej…

This study compares three common heart medications (nicorandil, diltiazem, and isosorbide mononitrate) to see which best prevents the narrowing or failure of radial artery grafts used in coronary artery bypass surgery. About 150 adults who recently had bypass surgery will take on…

This study looked at how well the Xience Sierra drug-coated stent works in a broad group of heart disease patients, including those with diabetes or prediabetes. Over 1,700 participants received the stent during a routine procedure to open blocked arteries. Researchers tracked he…

This study looked at whether high-intensity breathing exercises (inspiratory muscle training) can improve blood vessel function and artery stiffness in people with heart disease before they start cardiac rehab. Eleven adults who had heart surgery or related conditions took part. …

This study tested a special stent made of magnesium that slowly dissolves in the body. The stent releases a drug to prevent scarring and was used in 20 patients with complex blockages where arteries branch. The goal was to see if it is safe and works well for these tricky cases.

This study looked at whether using a person's genetic information to choose their blood-thinning medication (clopidogrel or an alternative) leads to better outcomes after a heart procedure. 283 adults with chronic coronary artery disease who had a stent placed were split into two…

This completed study tested whether a special ultrasound scan (IVUS) of plaque buildup in heart arteries can accurately diagnose reduced blood flow (functional myocardial ischemia). Researchers enrolled 105 adults with coronary artery disease and compared IVUS results to the stan…

This study tested a new software program that analyzes heart angiogram images to measure blood flow blockages without needing to insert a pressure wire into the artery. Researchers reviewed the records of 100 patients who had both an angiogram and an invasive pressure measurement…

This study tests whether giving a nerve block (stellate ganglion block) before coronary artery bypass grafting (CABG) can reduce the chance of developing atrial fibrillation, a common irregular heartbeat after surgery. About 60 adults having CABG will be randomly assigned to rece…

This study tested whether a parasternal block—an injection of the numbing drug ropivacaine into the chest wall—could reduce the amount of anesthetic needed to keep heart rate and blood pressure stable during coronary artery bypass surgery. Thirty-five patients were randomly assig…

This completed study looked at how much radiation people receive during heart CT scans (CCTA) in everyday hospital practice. Researchers enrolled 66 adults who needed a heart CT and recorded the radiation dose used, along with any dose-saving techniques. The goal was to understan…

This study aims to develop a computer model that can predict how well blood flows to the heart muscle during stress, using only a standard CT scan. Currently, this requires an additional scan and a drug to simulate stress. The researchers will analyze CT scans from 400 people wit…

This study looked at over 3,300 people having a heart procedure through the wrist artery. Doctors tested different types of introducers (the tube used to access the artery) to see if a smaller size or a special coating could lower the risk of problems like artery blockage or spas…

This study looked at how a nerve condition called cardiovascular autonomic neuropathy (CAN) affects the risk of kidney injury in people having heart bypass surgery. Researchers tracked 912 adults before, during, and after surgery to see if those with CAN had worse kidney function…

This study interviewed 15 children aged 12 to 21 who have bleeding or clotting disorders. Researchers asked about their quality of life, confidence in managing their condition, and how they view the care they receive. The goal is to better understand the real-life challenges thes…

This completed study looked at 160 people with coronary artery disease who needed a stent in one artery and also had a partial blockage in another. Researchers measured pressure in the second blockage before and after stenting the first, to see if treatment changed the reading. T…

This study compared radiation exposure to doctors during heart procedures (coronary angiography and stenting) using two different arm artery approaches: the left distal radial artery and the conventional right radial artery. Over 1,000 patients participated. The goal was to see i…

This study involved 150 people with completely blocked heart arteries who had a special procedure called STAR. Researchers wanted to find the best time to place a stent afterward—either 5-7 weeks or 12-14 weeks later. The goal was to see which timing leads to a more successful st…

This study used cardiac CT scans to compare the amount of high-risk plaque in the coronary arteries of 480 people with and without a family history of coronary artery disease. All participants had no prior heart problems. The goal was to see if those with a family history have mo…

This completed study looked at 258 people with different types of cardiomyopathy (a disease of the heart muscle) to see if special imaging could predict stroke risk. Researchers used echocardiograms and MRI scans to measure blood flow in the heart and check for silent brain infar…