Breast carcinoma in situ

This phase 2 trial tests whether a probiotic blend called WBF-038 can prevent bone loss in women with early-stage hormone receptor-positive breast cancer who are about to start aromatase inhibitor therapy. Aromatase inhibitors lower estrogen, which can weaken bones. The study wil…

This study tests whether a new type of radiation machine that uses MRI to guide treatment is safe and practical for people with gastric, breast, or other cancers. About 70 adults will receive radiation guided by real-time MRI, sometimes with chemotherapy. The goal is to see if th…

This study is testing whether adding calorie restriction to a precise, high-dose radiation treatment (SABR) before surgery can shrink breast tumors more than radiation alone. About 80 adults with early-stage breast cancer will be randomly assigned to either standard dietary advic…

This study compares magnetic resonance imaging (MRI) with standard diagnostic techniques like mammography to see which method best finds and defines breast cancer. Researchers will enroll about 500 women with suspicious breast lesions to evaluate accuracy. The goal is to improve …

This study tests whether adding high-dose omega-3 fatty acids to low-dose tamoxifen can lower breast cancer risk more than tamoxifen alone. It includes 66 overweight or obese postmenopausal women at increased risk for breast cancer. The goal is to see if the combination improves …

This phase II trial tests whether a natural supplement called fisetin, found in strawberries, combined with exercise can prevent frailty in postmenopausal women who have had early-stage breast cancer. Fisetin may help clear aging cells that cause inflammation and damage healthy t…

This study is for premenopausal women at higher-than-average risk for breast cancer. It tests whether a low dose of tamoxifen can safely reduce breast density, which is linked to cancer risk. About 200 women will take tamoxifen, and doctors will adjust the dose if needed to get t…

This study tests whether acolbifene or a low dose of tamoxifen can reduce breast cancer risk in premenopausal women at high risk. Both drugs block estrogen from reaching breast cells. Researchers will measure changes in breast tissue, blood, and mammograms over six months in 80 w…

This study compares annual mammograms to a personalized screening schedule based on each woman's breast cancer risk. Participants choose or are assigned to either annual screening or risk-based screening, which uses genetic testing and personal history. The goal is to see if pers…

This study tests a laser treatment for vaginal dryness in breast cancer survivors. Many survivors experience this side effect from cancer treatments like chemotherapy or hormone therapy. The trial will compare the laser to no treatment in 250 women to see if it improves symptoms.

This study looks at whether a nerve graft during nipple-sparing mastectomy can help restore feeling in the nipple. About 20 women with early-stage breast cancer will be randomly assigned to receive the nerve graft or not. The goal is to see if the procedure improves sensation and…

This trial tests whether a patient navigation program can help breast cancer survivors schedule and attend appointments for supportive services like counseling, exercise, and nutrition advice. Many survivors have unmet needs for such care, but participation is low, especially amo…

This study tests whether a gentle massage technique called manual lymphatic drainage (MLD) can reduce swelling, pain, and other side effects in women receiving radiation therapy after breast-conserving surgery for early-stage breast cancer. Fifty women will be enrolled, and resea…

This study tests whether a dietary supplement called resistant potato starch can help prevent joint pain and stiffness caused by aromatase inhibitors, a common breast cancer treatment. About 20 people with stage 0-III breast cancer or at high risk for it will take the supplement …

This study tests whether nurse-delivered hypnosis before and during breast cancer surgery can lower the amount of opioid painkillers patients need after surgery. About 225 adults having breast surgery will be randomly assigned to receive hypnosis plus standard anesthesia, standar…

This study tests an 8-week virtual rehab program (CaRE@Home) for adults who finished cancer treatment for breast, colorectal, head and neck cancers, or lymphoma within the last two years. The goal is to see if the program reduces disability and improves physical function, anxiety…

This study tests whether Revaree Plus, a hyaluronic acid vaginal suppository, can improve vaginal dryness in women with hormone-receptor-positive breast cancer. About 60 participants will use the suppository for 8 weeks. Researchers will measure changes in vaginal health using a …

This study compares two standard exercise programs to see which one better helps women increase muscle mass after breast cancer treatment. Thirty women aged 20-89 who have completed treatment (except chemotherapy) will follow either standard resistance training or a special 6-12-…

This study looks at whether a web-based tool called CONSYDER can help young women (ages 18-44) newly diagnosed with early-stage breast cancer make more informed decisions about their surgery. Participants will use the tool and complete surveys before and after their surgical cons…

This study follows 960 women at high risk for breast cancer to see if their diet's inflammatory potential is linked to cancer risk. Participants complete questionnaires and physical exams over time. The goal is to identify modifiable risk factors to improve prevention and early d…

This study looks at how aromatase inhibitor therapy changes skin quality and self-esteem in breast cancer survivors. Researchers will use skin imaging and surveys to track changes in 35 women starting this hormone therapy. The goal is to better understand and manage these side ef…

This study is observing how a genetic test called DCISionRT influences treatment decisions for people with ductal carcinoma in situ (DCIS), a very early form of breast cancer. The test predicts the risk of the cancer returning over 10 years and whether radiation therapy would be …

This study compares two methods for marking non-palpable breast tumors before surgery: magnetic clips and traditional metal wires. Researchers will track costs, how well the marker finds the tumor, and patient satisfaction in 772 women across France. The goal is to see if magneti…

This study tests whether augmented reality (AR) can help surgeons locate non-palpable breast tumors during surgery, replacing the current method that uses a metal wire inserted under local anesthesia. Twenty women with early breast cancer will receive an extra MRI and 3D camera i…

This study collects tissue, blood, and optional rectal swabs from 200 adults with breast cancer or carcinoma in situ. Samples are taken during standard procedures like surgery. Researchers will analyze them to identify tumor biomarkers and genetic profiles, aiming to better under…