Borderline personality disorder

This early-stage study is testing whether combining standard psychiatric medications (like antidepressants and anti-anxiety drugs) with individual cognitive behavioral therapy can improve symptoms and daily functioning in people with anxiety, depression, PTSD, OCD, bipolar disord…

This study tests whether a noninvasive brain stimulation technique called iTBS-TMS can reduce suicide risk in adults with major depression or borderline personality disorder who are experiencing suicidal thoughts. Participants receive either real or sham (placebo) stimulation to …

This study tests whether allowing people with borderline personality disorder and a history of self-harm to admit themselves for up to three nights (three times per month) reduces the use of compulsory (forced) psychiatric care. Researchers will compare clinics that implement thi…

This study looked at whether schema therapy, a type of talk therapy, can help people with personality disorders who are in outpatient forensic care. Five participants received therapy for up to two years. Researchers measured changes in their thinking patterns, risk of re-offendi…

This study tests whether an 8-week mindful self-compassion program can reduce self-harm, improve emotional control, and boost quality of life in 60 adults with borderline personality disorder. Participants learn mindfulness and self-kindness techniques. The goal is to see if this…

This early-stage study tests whether a new medicine called BI 3031185 is safe and well-tolerated in adults with borderline personality disorder (BPD) or attention-deficit/hyperactivity disorder (ADHD). About 96 participants will receive either the drug or a placebo in a crossover…

This study explores whether a single-session sleep training program can improve sleep and reduce symptoms of borderline personality disorder (BPD) in teenagers. Teens aged 13-18 with BPD symptoms will receive a brief intervention based on the TSC-Youth protocol, which teaches hea…

This trial tests a new couple-based therapy called Sage for people with borderline personality disorder who struggle with self-injury or suicidal thoughts. The therapy, delivered remotely over 12 sessions, aims to reduce these behaviors by addressing both emotional distress and r…

This study tested whether Caplyta (lumateperone), a drug already used for other mental health conditions, can reduce symptoms of borderline personality disorder (BPD). Sixty adults with BPD received either Caplyta or a placebo pill for 8 weeks. Researchers measured changes in BPD…

This study tests a short-term therapy for adults with borderline personality disorder. After a 2-4 week observation period, 30 participants receive six weekly therapy sessions. Researchers measure symptom changes using clinician and self-report scales, then follow participants fo…

This study tested a program called Family Connections for caregivers of people with both an eating disorder and a personality disorder. The goal was to see if the program could reduce stress and conflict at home. 124 Spanish caregivers took part, and researchers measured things l…

This study tested an experimental drug called vafidemstat in 211 adults with borderline personality disorder (BPD) to see if it could reduce agitation and aggression. Participants took either the drug or a placebo for 14 weeks. The goal was to measure changes in symptom severity …

This study tested whether real-time brain feedback (rtfMRI) could help people with borderline personality disorder increase brain activity in the amygdala while recalling happy memories. Thirty adults with the condition completed the training over several weeks. The goal was to s…

This study compares a 6-month version of dialectical behaviour therapy (DBT) to the standard 1-year program for people with borderline personality disorder who repeatedly self-harm. Researchers want to see if the shorter therapy is just as good at reducing self-harm and is more c…

This study tested whether a smartphone app called SAM could help adults with borderline personality disorder traits manage daily stress. Sixteen participants used the app for four weeks, answering quick stress questions several times a day and getting feedback on their patterns. …

This study tested if group therapy using dialectical behavioral therapy (DBT) works better than one-on-one supportive therapy for people with borderline personality disorder. 66 adults took part, and researchers looked at depression, impulsivity, suicide risk, and other factors. …

This study tested whether watching short online videos about borderline personality disorder (BPD) could help people recently diagnosed with the condition. 83 adults with BPD watched either BPD-specific videos or general mental health videos over two weeks and completed daily sur…

This small Phase 2 trial tested a single 25mg dose of psilocybin in 9 adults with both major depressive disorder and borderline personality disorder. Researchers measured changes in depression and BPD symptoms over time. The goal was to see if psilocybin is safe and could help ea…

This study looked at how empathy works in people with borderline personality disorder (BPD). Researchers used a computer test and questionnaires to measure two types of empathy: understanding others' thoughts and feeling their emotions. About 30 participants were assessed four ti…

This study looked at how the brain's 'mirror system' for touch works in people with borderline personality disorder (BPD). Researchers used a non-invasive brain stimulation technique called TMS to temporarily change brain activity while participants watched a hand being touched. …

This small study looked at whether Mentalization-Based Therapy (MBT) helps people aged 60 and older who struggle in relationships. Researchers recruited 3 participants and used interviews and questionnaires to see if the therapy improved their ability to understand their own and …