New pill aims to calm borderline personality disorder symptoms

NCT ID NCT04932291

Completed Symptom relief Sponsor: Oryzon Genomics S.A. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental drug called vafidemstat in 211 adults with borderline personality disorder (BPD) to see if it could reduce agitation and aggression. Participants took either the drug or a placebo for 14 weeks. The goal was to measure changes in symptom severity using doctor and patient questionnaires.

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Conditions

The condition(s) this trial relates to.

borderline personality disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BORDERLINE PERSONALITY DISORDER

Contacts and locations

Locations

Adams Clinical Trials, LLC

Watertown, Massachusetts, 02472, United States
Center for Emotioal Fitness

Cherry Hill, New Jersey, 08002, United States
Clinic for psychiatric disorders "Laza Lazarevic"

Belgrade, 11000, Serbia
Clinical center Kragujevac

Kragujevac, 3400, Serbia
Clinical center of Serbia

Belgrade, 11000, Serbia
Core Clinical Research

Everett, Washington, 98201, United States
DCC "Mladost-M" Ltd, Psychiatr

Varna, 9000, Bulgaria
Emovis GmbH

Berlin, 10629, Germany
Excell Research Inc

Oceanside, California, 92056, United States
Excell Research, Inc.

Oceanside, California, 92056, United States
Hospital Clínico San Carlos

Madrid, 28040, Spain
Hospital Vall d'Hebron

Barcelona, 08035, Spain
Klinik fur Psychiatrie und Psychotherapie, LMU

München, Bavaria, 80336, Germany
Medical Center Hera EOOD - Psychiatry Office

Sofia, Sofia-Grad, 9000, Bulgaria
Medical Center Intermedika

Sofia, Sofia-Grad, 1680, Bulgaria
Neurobehavioral Research Inc.

Cedarhurst, New York, 11516, United States
New Life Medical Research Center

Hialeah, Florida, 33012, United States
Phoenix Medical Research LLC

Miami, Florida, 33165, United States
Revive Research Institute

Elgin, Illinois, 60123, United States
The Medical Research Network

New York, New York, 10128, United States
University of Chicago Institutional Review Board

Chicago, Illinois, 60637-1426, United States

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