Borderline personality disorder
MONDO:0001156A disorder characterized by an enduring pattern of unstable self-image and mood together with volatile interpersonal relationships, self-damaging impulsivity, recurrent suicidal threats or gestures and/or self-mutilating behavior.
Also known as: BPD, borderline personality disorder, borderline personality disorder (disease)
79 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Can a 4-week therapy program curb teen self-harm? new pilot aims to find out
Symptom relief ENROLLING_BY_INVITATIONThis study tests a shortened, 4-week version of dialectical behavior therapy (DBT) for 12 teens aged 14-18 who have recently harmed themselves or attempted suicide. The goal is to see if this intensive program is practical and helps reduce self-harm, suicide attempts, and depress…
Phase: NA • Sponsor: Haukeland University Hospital • Aim: Symptom relief
Last updated Aug 15, 2026 00:00 UTC
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Horses help heal: new therapy for personality disorder patients
Symptom relief OngoingThis small study will test whether spending time with horses as part of therapy can help inpatients with emotionally unstable personality disorder (EUPD) manage their emotions and feel more connected to others. Six participants will take part in six sessions of equine-assisted ps…
Phase: NA • Sponsor: Cygnet Healthcare • Aim: Symptom relief
Last updated Jul 02, 2026 00:00 UTC
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Can rewriting your life story improve mental health? small trial tests new therapy
Symptom relief OngoingThis study tests a therapy called RETELL that helps people with severe mental illness explore and reshape their life stories. The goal is to improve personal recovery, quality of life, and identity. Twenty adults with conditions like schizophrenia, bipolar disorder, or PTSD will …
Phase: NA • Sponsor: University of Aarhus • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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Which therapy format works best for borderline personality disorder?
Symptom relief ENROLLING_BY_INVITATIONThis study looks at two ways of giving schema therapy to people with borderline personality disorder (BPD): one-on-one sessions or a mix of individual and group sessions. The goal is to see which format reduces BPD symptoms more and has fewer people dropping out early. About 132 …
Phase: NA • Sponsor: University of Amsterdam • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Can four therapy sessions curb suicide risk in BPD? new trial aims to find out
Symptom relief ENROLLING_BY_INVITATIONThis study tests a 4-session psychological intervention for people with borderline personality disorder who come to the emergency department with suicidal thoughts or self-harm. The therapy focuses on education, problem-solving, and safety planning, and may include a family membe…
Phase: NA • Sponsor: Centre for Addiction and Mental Health • Aim: Symptom relief
Last updated Jun 27, 2026 09:05 UTC
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Magnetic brain zaps aim to tame borderline personality disorder
Symptom relief OngoingThis pilot study tests whether gentle magnetic brain stimulation (TMS) can help people with borderline personality disorder better control their emotions and impulses. Up to 20 participants will receive brain scans, up to 3 TMS sessions, and computer tests over about 3 weeks. The…
Phase: NA • Sponsor: University of California, Los Angeles • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Writing your way to wellness: new study tests creative writing for mental health
Symptom relief OngoingThis study tests a 15-session creative writing program called REWRITALIZE for people with serious mental illnesses like schizophrenia, bipolar disorder, or severe depression. About 300 adults will either join the writing groups plus their usual care, or stay on a waiting list wit…
Phase: NA • Sponsor: Amager Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 09:01 UTC
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Can a brain zap boost therapy for borderline personality disorder?
Symptom relief OngoingThis study combines a type of brain stimulation called rTMS with dialectical behavioral therapy (DBT) to see if it helps people with borderline personality disorder more than therapy alone. Sixty participants will receive both treatments over several months. Researchers will meas…
Phase: NA • Sponsor: Masarykova Univerzita • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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Can online therapy plus In-Person sessions help personality disorders?
Symptom relief OngoingThis study is testing a new type of therapy called Blended Dynamic Interpersonal Therapy (B-DIT) for adults with personality disorders. The therapy mixes face-to-face sessions with online modules over several months. The goal is to see if this approach is acceptable to patients a…
Sponsor: De Viersprong • Aim: Symptom relief
Last updated Jun 26, 2026 15:50 UTC
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Can a longer hospital stay save lives? a nationwide study investigates
Knowledge-focused OngoingThis study looks at whether long (over 5 days) or compulsory psychiatric hospital stays affect self-harm and suicide in people with borderline personality disorder. Researchers will compare clinics across Sweden that use these practices more or less often, tracking outcomes like …
Sponsor: Lund University • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC
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Can special training help therapists connect better with BPD patients?
Knowledge-focused OngoingThis study looks at two ways to train therapists who work with people with borderline personality disorder (BPD). The goal is to see if extra practice and feedback can help therapists better notice and respond to problems in the therapy relationship. About 80 therapists in Canada…
Phase: NA • Sponsor: York University • Aim: Knowledge-focused
Last updated Jul 31, 2026 00:00 UTC
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Love hormone nasal spray tested for borderline personality disorder trust issues
Knowledge-focused TerminatedThis pilot study looks at whether a nasal spray of oxytocin, sometimes called the 'love hormone,' can improve trust and cooperation in people with borderline personality disorder (BPD). About 40 participants (some with BPD, some healthy) will play a trust game after receiving eit…
Phase: NA • Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Knowledge-focused
Last updated Jul 04, 2026 00:00 UTC
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Study on teen body drawings withdrawn before starting
Knowledge-focused TerminatedThis study was designed to explore how adolescents with and without borderline personality disorder represent their inner body through drawings, interviews, and questionnaires. It aimed to identify differences in the types and number of organs drawn, as well as emotional or symbo…
Phase: NA • Sponsor: Centre Hospitalier Intercommunal Creteil • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Real-World therapy study seeks to unlock secrets of personality disorder treatment
Knowledge-focused OngoingThis study follows 91 adults with personality disorders who are receiving intensive psychodynamic therapy in a real-world clinic. Researchers want to see if the therapy works as well outside of strict research settings and what specific factors lead to improvement. The goal is to…
Sponsor: KU Leuven • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC