Bipolar depression

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study compares dapagliflozin and metformin for managing weight gain caused by antipsychotic medications. About 110 adults aged 16 and older will take one of the drugs plus lifestyle advice for 26 weeks. The goal is to see which drug works better and is safer for weight contr…

This study tests a short case management program for people who have been involuntarily admitted to a psychiatric hospital. The program, designed with input from people who have experienced coercion, provides up to five sessions with a nurse or social worker starting during the h…

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve depression in people with bipolar disorder. Researchers use brain scans to create a personalized map for each participant, targeting the exact brain circuits involved in mood shifts. Parti…

This Phase 3 trial tests whether pramipexole, a dopamine-boosting drug, can ease anhedonia (loss of pleasure) in people with bipolar depression. 126 participants will receive either pramipexole or a placebo alongside their usual mood stabilizer for 6 weeks. The study aims to impr…

This study compares two drugs, lumateperone and cariprazine, when added to a mood stabilizer for people with bipolar I depression. Researchers will track changes in depression symptoms over 8 weeks using standard rating scales. The goal is to see which drug works better and has f…

This study tests an oral ketamine capsule (KET-AD) designed to be abuse-deterrent in adults with treatment-resistant bipolar depression. About 160 participants will receive either KET-AD or a placebo, taken three times a week for up to 7 weeks, alongside their usual treatment. Th…

This study tests whether baricitinib, an anti-inflammatory drug, can improve depression and cognitive symptoms in 30 male former football players aged 40-55 with at least 10 years of play. Participants take the drug every other week for 6 weeks, and researchers use brain scans an…

This study tests whether combining ketamine infusions with dialectical behavioural therapy (DBT) can reduce suicidal thoughts more effectively than a placebo plus DBT. About 120 adults with borderline personality disorder and treatment-resistant depression or bipolar disorder wil…

This study tests whether two anti-inflammatory medications, celecoxib or minocycline, can reduce depression symptoms in adults with major depressive disorder or bipolar depression. About 42 participants will take one of the drugs for 8 weeks and have their depression levels measu…

This study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…

This study tests a wearable light device (Vielight RX Gamma) that shines light on the brain to see if it safely eases bipolar depression symptoms. Forty people with bipolar disorder will either get the active device or a sham (inactive) one, using it in the clinic 5 days a week f…

This study tests whether empagliflozin, a drug used for diabetes, can help reduce depression in people with bipolar disorder who also have insulin resistance. Twenty adults with bipolar depression will take the drug for 12 weeks alongside their usual treatment. The goal is to see…

This study tests whether a single 'Braining' group exercise session can quickly reduce anxiety in people receiving psychiatric care. Thirty participants will rate their anxiety before and after the session. The goal is to see if exercise can be a fast-acting tool to ease symptoms…

This study tests a new program called CapExchange, where people with stable mental health conditions exchange practical skills with others in their community. The goal is to see if this approach is practical and helpful for improving well-being and social connection. About 10 to …

This study aims to adapt and validate a French version of the Recovery Assessment Scale (RAS), a questionnaire that measures how people feel about their own recovery from mental health conditions. Researchers will ask 260 adult psychiatric patients in France to fill out the RAS a…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This study will test a tool called the Health Improvement Profile (HIP) in a mental health inpatient unit. The HIP is a checklist that helps clinicians spot physical health problems like high blood pressure or poor diet in people being treated for mental illness. Researchers will…

This study aims to better understand psychiatric disorders, thinking problems, and treatment side effects in 2000 cancer patients and their close relatives. Researchers will compare those with and without mental health issues to find patterns and improve care. No new treatments a…

This study will check how much psychiatric clients know about occupational therapy (OT) and whether their expectations are realistic. It will also evaluate how well OT interns explain health information and conduct interviews. Researchers will develop new tools to measure these s…

This study will test a digital tool called AI-COA® to see how well it measures the severity of depression and anxiety compared to standard clinician ratings. About 150 adults in the U.S. who are starting a new treatment for depression or anxiety will use the tool over 12 weeks. T…

This study will follow 2,000 adults with major depressive disorder or bipolar disorder to understand why some people get better with treatment and others do not. Researchers will collect information on symptoms, thinking abilities, genetics, metabolism, proteins, and immune marke…

This study aims to better understand why young people (ages 18-25) with mood disorders may be at risk for suicide. Researchers will collect clinical, brain imaging, genetic, and microbiome data from 180 participants to identify risk factors. They will also test whether a non-inva…