Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins

This study aimed to test whether giving targeted drugs before surgery could improve outcomes for people with operable non-small cell lung cancer who have a specific genetic mutation (KRAS G12C). The trial planned to give patients either a drug called adagrasib alone or combined w…

This study is testing a special vaccine in healthy relatives of people with advanced HPV-linked cancer. The goal is to see if the vaccine safely boosts the donor's immune cells against HPV. Those immune cells are then collected and given to their sick relative in a separate treat…

This study is testing if aiming a higher dose of radiation at a specific area of the brain, called the subventricular zone, can help control a fast-growing brain tumor (glioblastoma) for longer than standard radiation. Patients receive the usual chemotherapy alongside the radiati…

This study is testing whether continuing the drug palbociclib, but pairing it with a different hormone therapy called fulvestrant, can help control metastatic breast cancer that has started growing again after initial treatment. It will involve about 60 people whose cancer progre…

This study is testing a new combination treatment for early-stage bladder cancer in patients who haven't received the standard BCG therapy. Participants receive the drugs directly into the bladder through a catheter, starting with weekly treatments for six weeks, then monthly if …

This study is testing whether giving two immunotherapy drugs before surgery is safe and can help shrink tumors in people with head and neck cancer. The drugs, nivolumab and BMS-986253, aim to boost the body's immune system to attack the cancer. Researchers will see if this approa…

This early-stage study is testing whether giving one or two immunotherapy drugs before and after surgery is safe and helpful for people with liver cancer that can be removed. The goal is to see if the drugs shrink the tumor before surgery and help prevent the cancer from coming b…

This early-stage study is testing a new proton radiation technique called Pro-GRID for patients with large, difficult-to-treat tumors. The method delivers radiation in a grid pattern to try to shrink tumors while sparing healthy tissue. Researchers aim to see if this approach is …

This early-stage trial is testing whether combining two immunotherapy drugs with a precise, high-dose radiation treatment is safe and might help control recurrent glioblastoma, a very aggressive brain cancer. The study involves about 16 patients whose cancer has returned after in…

This study is testing a new combination of immune-based treatments for pancreatic cancer. It gives patients a cancer vaccine and a drug that helps the immune system fight cancer, both before and after surgery to remove the tumor. The main goal is to see if this approach is safe a…

This study is testing whether combining three drugs—paclitaxel, pembrolizumab, and olaparib—is safe and can help control advanced stomach cancer. It is for people whose cancer has continued to grow after trying one prior treatment. The main goal is to see if this combination help…

This study is testing a new combination of three drugs given before surgery for early-stage, hormone-sensitive breast cancer. The goal is to see if adding an immunotherapy drug (avelumab) to standard hormone-blocking treatments helps shrink tumors more effectively. Researchers wi…

This early-stage study is testing the safety and best dose of a new two-drug pill combination (cedazuridine with decitabine) for people with advanced solid tumors. It is for patients whose cancer has continued to grow despite at least two prior treatments and who have no other go…

This study is testing whether giving immunotherapy drugs before surgery is safe and can help shrink tumors in patients with operable non-small cell lung cancer. It involves 39 participants who will receive one or two immunotherapy drugs, or a combination of immunotherapy and chem…

This early-stage study is testing whether a drug called itacitinib can make stem cell transplants safer for older patients with blood cancers. The goal is to prevent a severe, potentially life-threatening immune reaction called cytokine release syndrome (CRS) that can occur after…

This study is testing if adding a drug called vorinostat to standard chemotherapy helps shrink breast tumors more effectively before surgery. It involves 68 women with operable, HER2-negative breast cancer who are randomly assigned to receive the standard chemo drugs or the stand…

This early-stage study is testing a personalized vaccine designed to target specific mutations found in colorectal and pancreatic cancers. The vaccine is combined with two immunotherapy drugs (nivolumab and ipilimumab) to help the body's immune system recognize and attack cancer …

This study is testing a combination of four drugs (CRS-207, pembrolizumab, ipilimumab, and tadalafil) to see if it is safe and can help control advanced pancreatic cancer that has spread and has gotten worse after at least one round of prior chemotherapy. It is for adults whose c…

This study is testing if adding an experimental drug called LY2157299 to the standard drug enzalutamide can help men with advanced prostate cancer that has stopped responding to hormone therapy. It will compare how long the cancer stays under control with the combination versus e…

This early-phase study is checking the safety of combining an immunotherapy drug (nivolumab) with a very precise, high-dose radiation treatment for patients whose chordoma has come back or spread. It will enroll about 21 people to see how well they tolerate the treatments and to …

This study is testing if giving targeted, high-dose radiation to cancer spots before starting immunotherapy drugs makes the drugs work better for people with advanced stomach or esophageal cancer. It's a small, early-stage safety trial for patients whose cancer has spread but is …

This study aimed to collect and store prostate tissue samples from men undergoing brachytherapy (a type of radiation seed implant) for prostate cancer. The goal was to build a tissue bank for researchers to study how prostate cancer and its surrounding tissue respond to radiation…

This study is testing whether advanced MRI scans can detect early changes in prostate cancer and surrounding healthy tissues during radiation therapy. Researchers will scan 38 men at three points in their treatment to see if the MRI results can predict treatment effectiveness or …