Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins

This study tests an experimental DNA vaccine called pBI-11 in 48 women with persistent HPV16 or HPV18 infection. The vaccine is designed to boost the immune system to clear the virus, which can cause cervical cancer. Participants receive either the vaccine or a placebo via a spec…

This study looks at a procedure called total pancreatectomy with islet autotransplantation (TPIAT) in 30 adults with pancreatic or nearby tumors who are at high risk for a leak after standard surgery. The goal is to see if removing the whole pancreas and transplanting the patient…

This study tests whether adding a targeted radiation drug (177Lu-PSMA-617) to standard radiation allows men with high-risk prostate cancer to take hormone therapy for only 6 months instead of the usual 24 months. The goal is to see if the shorter hormone course is just as effecti…

This early-phase study tests a combination of a personalized vaccine (targeting a specific cancer protein) with three other drugs for people with advanced fibrolamellar liver cancer that has worsened despite prior treatment. The goal is to see if the combination is safe and can s…

This early study tests the drug ruxolitinib for a rare but serious inflammatory condition called IEC-HS that can happen after CAR-T cell therapy for cancer. Sixteen adults will take the drug twice daily for up to 8 weeks. Researchers will check if the treatment helps control the …

This study tests whether adding immunotherapy drugs (cemiplimab alone or with fianlimab or REGN7075) to standard chemotherapy (CAPOX) can eliminate or shrink rectal cancer before surgery. About 66 adults with a specific type of rectal cancer (MSS, locally advanced) who have not h…

This study tests whether adding an experimental drug (DCSZ11) to standard radiation and chemotherapy can improve outcomes for people with a high-risk type of rectal cancer. About 30 adults with mismatch repair proficient (pMMR) locally advanced rectal cancer will receive the comb…

This study will test if virtual music therapy is practical and helpful for people newly diagnosed with glioblastoma, a serious brain cancer. Researchers will enroll 35 patients who have completed standard treatment. The goal is to see if music therapy can improve well-being durin…