Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins

This early study tested a vaccine called TA-CIN in 15 people who had been treated for HPV16-related cervical cancer and were cancer-free at the start. The goal was to see if the vaccine is safe and can boost the body's immune response against the virus. Researchers measured side …

This study tested a shorter course of radiation therapy (16 sessions instead of the usual 40+) for men with early-stage prostate cancer. The goal was to see if this approach is safe and effective at controlling the cancer while reducing side effects. 91 men participated, and rese…

This study tested a new way to treat men with advanced prostate cancer that no longer responds to standard hormone therapy. Fifteen men took high-dose oral testosterone for one week, then no treatment for one week, repeating for three months. If the cancer worsened, they switched…

This study tested a combination of a pancreatic cancer vaccine (GVAX), an immunotherapy drug (pembrolizumab), and focused radiation (SBRT) in 58 people with locally advanced pancreatic cancer. The goal was to see if this mix could delay the spread of cancer to other parts of the …

This study tested a combination of focused radiation and short-term hormone therapy in 45 men with intermediate-risk prostate cancer. The goal was to see how well the treatment controls the disease and what side effects occur. Participants received radiation over 5 sessions along…

This study tested a less intense bone marrow transplant for people with blood cancers who couldn't find a perfectly matched family donor. It used partially matched donors who were not first-degree relatives. The goal was to see if this approach could reduce severe side effects li…

This study tested a combination of two drugs, copanlisib and nivolumab, in 48 adults with advanced solid tumors that had stopped responding to standard treatments, focusing on a type of colorectal cancer called MSS. The goal was to see if the combination was safe and could shrink…

This study tested a combination of two drugs (durvalumab and SNDX-6352) in 5 adults with a rare liver cancer that could not be surgically removed. The goal was to see if the treatment was safe and could shrink tumors after standard liver-directed therapy. The trial is complete, a…

This study tested whether adding a bone-seeking radioactive drug (Radium-223) to targeted radiation (SABR) helps men with prostate cancer that has spread to a few spots (oligometastatic). 64 men participated, and the main goal was to see how long the cancer stayed under control. …

This study tested a combination of four drugs (CRS-207, pembrolizumab, ipilimumab, and tadalafil) in 17 adults with metastatic pancreatic cancer that had worsened after at least one prior chemotherapy. The goal was to see if the treatment could shrink tumors and to check its safe…

This early-stage study tested a drug called flotetuzumab in 3 adults whose acute myeloid leukemia (AML) came back after a stem cell transplant. The main goal was to see if the drug is safe and find the best dose. Researchers also looked at whether the drug could help control the …

This study tested whether adding the drug enzalutamide to standard radiation therapy can help men whose prostate cancer has returned after surgery. 86 men with high-risk signs of recurrence took part. The goal was to see if the combination could delay cancer progression better th…

This early-phase study tested a combination of three immunotherapy drugs (nivolumab, BMS-813160, and GVAX) in 22 adults with locally advanced pancreatic cancer that could not be removed by surgery. All participants had already received chemotherapy and radiation. The main goals w…

This study tested a drug called pemigatinib in 30 people with a type of bladder cancer that keeps coming back. Participants took the drug for 4-6 weeks before their scheduled surgery to remove the tumor. The goal was to see if the drug could completely eliminate the cancer before…

This study tested the drug nivolumab in 8 men whose prostate cancer returned after initial treatment and who had specific genetic changes (MMR-deficient or CDK12-altered). The goal was to see if nivolumab could lower PSA levels without using hormone therapy. While the approach of…

This early-phase study tested whether adding two drugs (romidepsin and 5-azacitidine) to an immunotherapy (MK-3475) could help people with a specific type of advanced colorectal cancer called microsatellite stable (MSS). The study included 27 adults whose cancer had already sprea…

This early-phase study tested whether giving two immunotherapy drugs (nivolumab and ipilimumab) before standard treatments like surgery or radiation is safe and feasible for people with Neurofibromatosis Type 1 (NF1) who have a rare nerve tumor called MPNST. The trial enrolled 13…

This study tested if a local painkiller injected into the surgical site works as well as an epidural for pain after open gynecologic surgery. 106 adults participated. The goal was to see which method provides better pain control and recovery, and which is more cost-effective.

This study tested a personalized home exercise program for 34 cancer survivors who also had diabetes or high blood pressure. Participants chose from four exercise options (like walking or yoga) and used a wearable device to track their heart rate. The goal was to see if the progr…

This study tested whether a 12-week home exercise program using mobile technology, alone or combined with acupressure or mindfulness, could reduce fatigue in cancer survivors. 110 adults who had completed cancer treatment or were on immunotherapy took part. The goal was to see if…

This study looked at how radiation therapy changes the immune system's ability to recognize and attack stage I non-small cell lung cancer tumors. Researchers took small tissue samples (biopsies) before and after radiation to see if the treatment activates T-cells, which are key i…

This early-phase study looked at whether giving a short, strong dose of flutamide (a hormone blocker) can create DNA breaks in prostate cancer cells in men already receiving standard hormone therapy and brachytherapy. The goal was to see if this approach could make cancer cells m…

This study looked at whether having cancer patients report their own symptoms during radiation treatment helps doctors better understand and manage side effects. 104 adults with lung, esophageal, or other gastrointestinal cancers took part. Doctors reviewed patient-reported sympt…

This study collected blood and urine samples from 61 men with prostate cancer and healthy volunteers. Researchers analyzed the samples to find genetic differences between cancer cells and normal cells. The goal is to develop a non-invasive way to detect and monitor prostate cance…

This completed study looked at 126 adults aged 60 and older who had a bone marrow transplant for blood cancers like leukemia or lymphoma. Researchers measured physical abilities, mental health, and stress levels before and after transplant to find traits that help people recover …

This study watched 91 adults who had robotic surgery to remove part of the pancreas. The goal was to see how long they stayed in the hospital and how quickly they recovered. Researchers measured things like when pain was controlled with pills and when patients could eat enough on…

This study looked at tissue and blood samples from 49 people with sinonasal cancer to understand how high-risk HPV, tobacco, alcohol, and other behaviors might influence the disease. Researchers focused on differences by gender and race. The goal was to gather knowledge, not to t…