Ohsu Knight Cancer Institute

This early-stage trial is testing whether combining three different cancer drugs is safe and effective for people with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The study involves 27 participants who will receive tafasitamab, aca…

This early-stage trial is testing whether combining three different cancer drugs is safe and effective for patients with advanced solid tumors that have spread or stopped responding to standard treatments. The three drugs work in different ways: one attacks cancer cells directly,…

This early-stage study is testing if adding a new oral drug called pemigatinib to standard chemotherapy is safe and helpful for adults newly diagnosed with a higher-risk form of acute myeloid leukemia (AML). The goal is to find the best dose of pemigatinib, which works by blockin…

This study is testing a refined bone marrow transplant method for people with cancers or other disorders who need a transplant but lack a perfectly matched donor. Doctors use a special machine to filter and select only the most useful stem cells from a partially matched related d…

This study is testing whether removing a smaller border of healthy skin around an early-stage melanoma is as effective at preventing the cancer's return as the current standard of removing a wider border. It will enroll 1,000 adults with early-stage melanoma to see if the narrowe…

This study is testing a new three-drug combination (glofitamab, ibrutinib, and obinutuzumab) for people with untreated mantle cell lymphoma (MCL), a type of blood cancer. It is for patients aged 65 and older, or younger adults with high-risk features. The main goals are to see if…

This early-stage study is testing the safety and best dose of a new combination of oral pills (venetoclax and dasatinib) for adults with a specific, aggressive type of blood cancer called Philadelphia chromosome positive acute lymphoblastic leukemia (ALL) or mixed phenotype acute…

This study tests whether injecting three medications directly into the spinal fluid can prevent severe brain-related side effects in patients receiving CAR-T cell therapy for blood cancers. CAR-T therapy can cause dangerous neurological complications in 20-70% of patients, rangin…

This study is testing whether adding a targeted drug called venetoclax to a standard chemotherapy regimen works better than the current standard treatment for newly diagnosed acute myeloid leukemia (AML). It will involve about 102 adults and aims to see if the new combination lea…

This study is testing a new way to analyze MRI scans, called activity MRI (aMRI), to see if it can provide the same information about brain tumor activity as a standard PET scan. Researchers will compare the two scans in 20 adults with glioma to see if the new MRI method is a val…

This study is testing if using two different contrast agents (gadolinium and ferumoxytol) during a single MRI scan can improve the detection and diagnosis of brain abnormalities, including tumors and metastases. It will involve 150 participants who have neurological symptoms or k…

This study is testing if a heart medication called amiodarone can prevent a common and serious irregular heartbeat (atrial fibrillation) after a specific type of esophageal cancer surgery. About 90 patients will be randomly assigned to receive either the real medication or a plac…

This study is testing whether creative arts activities like drawing, painting, and making sculptures can help improve symptoms and quality of life for children with cancer. Researchers will compare children doing art activities with children watching videos to see which approach …

This study is testing whether olanzapine, a medication that affects brain chemicals, can help cancer patients who are losing too much weight and have poor appetite. The trial will involve 66 adults with advanced cancers of the stomach, liver, pancreas, colon, or lung who have los…

This study is testing whether a simple blood test can help doctors decide the best treatment for people with rectal cancer. Researchers will measure cancer DNA in the blood of 50 patients before, during, and after their standard treatment. The goal is to see if this test can pred…

This study aims to understand how hormone therapy changes what doctors see on a special type of prostate cancer scan called a PSMA PET scan. Researchers will scan 80 men with prostate cancer before they start hormone therapy, and then again 8 days and 28 days later. The goal is t…

This study aims to learn if offering free genetic testing to the general public is a better way to find people with high inherited cancer risk than only testing those with a known family history. Researchers will enroll up to 27,500 adults, collect saliva samples for DNA testing,…

This study is testing whether a large-scale educational campaign across Oregon helps people learn the early signs of melanoma, a serious skin cancer. The program provides information to the public, high school students, and healthcare providers. Researchers will compare melanoma …

This early study aims to understand how six different investigational drugs affect the biology of pancreatic cancer tumors. It will enroll about 90 adults with various stages of pancreatic cancer. Participants take one of the drugs for about 10 days before a scheduled biopsy or s…

This study aims to understand if men and women experience the side effects of cancer immunotherapy differently. It will also compare how patients report their symptoms versus how their doctors assess them. Researchers will observe 100 adults with various cancers who are starting …

This early research study aims to understand how an experimental drug called OMO-103 affects pancreatic cancer cells in patients. Twelve adults with advanced pancreatic cancer will receive two infusions of the drug and undergo tumor biopsies to see if it changes the tumor's biolo…

This study aims to understand how taking a daily fiber supplement changes the community of bacteria and other microorganisms (the microbiome) in the colon. Researchers will enroll 120 adults with benign colon or anal conditions. Participants will take a fiber supplement daily for…

This study aims to understand if CAR-T therapy, a powerful cancer treatment, reduces the body's long-term protection from common vaccines like measles, mumps, and tetanus. Researchers will observe 45 adults with blood cancers, measuring their antibody levels before and after CAR-…