Less may be more: smaller surgery for melanoma tested in 1,000-Patient trial
NCT ID NCT06673095
First seen Mar 28, 2026 · Last updated Jun 23, 2026 · Updated 17 times
Summary
This study tests whether removing a smaller border of healthy tissue around a melanoma (narrow excision) works as well as the standard wider excision. About 1,000 adults with early-stage melanoma will be randomly assigned to one of the two surgeries. The goal is to see if narrow excision can reduce complications and improve quality of life without increasing the chance of the cancer coming back.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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OHSU Knight Cancer Institute
RECRUITINGPortland, Oregon, 97239, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospitals Cleveland Medical Center
NOT_YET_RECRUITINGCleveland, Ohio, 44106, United States
Contact Email: •••••@•••••
Contact
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University of California, Davis
NOT_YET_RECRUITINGDavis, California, 95817, United States
Contact Email: •••••@•••••
Contact
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University of Kentucky/Markey Cancer Center
NOT_YET_RECRUITINGLexington, Kentucky, 40536, United States
Contact Email: •••••@•••••
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University of Michigan
NOT_YET_RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact
Contact Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
surgical excision (narrow margin vs wide margin)
What this could lead to
If narrow excision works as well as wide excision, it could become the new standard for early-stage melanoma, reducing surgical side effects and improving recovery.
What could go wrong
This is a Phase 2/3 trial, so results are not yet proven. Narrow excision might lead to higher local recurrence rates, and the study is still recruiting.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.