Mcgill University Health Centre/research Institute Of The Mcgill University Health Centre

This study tests if a newer pacing method, left bundle branch pacing, is better than standard right ventricular pacing for people who need a pacemaker due to heart block. Standard pacing can sometimes weaken the heart over time, leading to heart failure. The trial will follow 1,3…

This study tests whether social prescribing—connecting patients with community resources for issues like housing, transportation, or loneliness—can help women with heart failure stick to their medications and improve their quality of life. About 200 women at high social risk will…

This study tests whether helping couples with type 2 diabetes walk more—by giving step counters and step prescriptions—can improve blood sugar control. Half of the 200 couples will also get counseling to improve communication and teamwork. Researchers will track steps and blood s…

This study looks at whether people with Crohn's disease or ulcerative colitis who are in deep remission can safely take less of the drug ustekinumab without their disease coming back. About 115 participants will either stretch their injections from every 4 weeks to every 8 weeks,…

This study tests whether canagliflozin, a diabetes medicine, can improve fluid removal and reduce scarring in the belly lining for 30 adults on peritoneal dialysis. Participants will take the drug or a placebo for 26 weeks each, then switch. The goal is to see if the drug helps d…

This study tests modified oral immunotherapy (OIT) protocols for peanut, milk, and egg allergies. It aims to see if using lower doses or processed allergens can desensitize patients while causing fewer allergic reactions. The study involves 360 participants and compares different…

This study tests whether canagliflozin, a drug used for diabetes, can improve heart structure and function in people with advanced kidney disease, including those on dialysis. About 92 participants will receive either the drug or a placebo, and heart changes will be measured usin…

This study looks at whether switching to a blood thinner called dabigatran can help people with a serious staph bloodstream infection. Participants are adults already taking a different blood thinner (apixaban, edoxaban, or rivaroxaban) for conditions like atrial fibrillation or …

This study tests whether taking oral vancomycin can prevent a repeat Clostridioides difficile infection in people who recently had one and now need another antibiotic. About 300 adults will receive either vancomycin or a placebo while on antibiotics, plus a week after. The goal i…

This study looks at whether measuring spleen stiffness with a non-invasive scan can help diagnose and monitor dangerous blood pressure in the liver (portal hypertension) in people with advanced chronic liver disease. About 200 adults will have regular scans and checkups to see if…

This study is testing shorter treatments (1-2 months) for people with latent TB infection, which means they carry the bacteria but aren't sick yet. The goal is to find a regimen that is safer and easier to complete than the current 4-month option. About 1,800 adults and children …

This study tests whether a gradual decrease (taper) of vancomycin can prevent repeat C. diff infections as well as the standard 10-day fidaxomicin treatment. About 500 adults with a first or second C. diff infection will be randomly assigned to one of the two approaches. The main…

This study compares three doses of a medicine called dexmedetomidine added to a standard numbing shot for arm surgery. The goal is to see if a higher dose keeps the arm numb and pain-free longer. About 69 adults having elbow, forearm, or hand surgery will take part.

This study tests whether doing a 10-minute paced breathing exercise every day for four weeks can help children and teens (ages 9-18) recover from a concussion. Participants either do the breathing exercises at home or receive usual care. The main goal is to see if the program is …

This study is testing whether a special blood test (biomarker signature) can help doctors decide when to use antibiotics for patients in the intensive care unit (ICU). About 1,200 ICU patients who have started antibiotics will be randomly assigned to have their treatment guided b…

This study looks at how to improve needle exchange programs in Canadian federal prisons so that more people who inject drugs use them. Researchers will work in nine prisons, including five women's prisons, to find what helps or hinders program use and put strategies in place to i…

This study follows 244 people with peroxisome biogenesis disorders (PBD), a group of rare inherited conditions that affect development and metabolism. Researchers will collect medical records, blood, urine, and imaging data over 5 years to better understand the disease and improv…

This study looks at 30 premature babies on bubble CPAP, a breathing machine that uses bubbles to deliver air. Researchers want to see if the sound of the bubbles can tell doctors how much pressure is reaching the baby's lungs. The goal is to find a new, non-invasive way to monito…

This study looks at whether a computer program for doctors and easy-to-read brochures for patients can help adults aged 60 and older with rheumatic conditions stop or reduce medications that may be risky. Researchers will follow 100 participants for about 18 months to track medic…

This study looks at how infertility and fertility treatments impact women's sexual function and behavior. About 500 women under 45 with infertility will fill out an anonymous questionnaire about their sexual experiences. The goal is to help doctors better support the sexual healt…

This study tests whether a 12-week virtual exercise and education program is practical for 30 adults with end-stage kidney disease who are frail and waiting for a kidney transplant. Participants will do home exercises and attend online sessions, with a 5-month follow-up. The goal…

This study is testing whether a new monitoring system is practical for extremely low birth weight infants after their breathing tube is removed. The system combines standard vital signs with special sensors that measure oxygen levels in the brain and gut, and lung function. The g…

This study tests whether a new smartphone app called elleFA can help women with endometriosis track their symptoms and communicate better with their healthcare team. Twenty pre-menopausal women aged 18 and older with known or suspected endometriosis will use the app for 6 months,…

This study follows 30 people with Zellweger Spectrum Disorder over 5 years to learn how their vision changes. Participants will have yearly eye tests, physical exams, and blood work. The goal is to better understand the disease and find the best ways to monitor vision loss.

This study looks at the best way to give COVID-19 booster and flu vaccines to people with weakened immune systems, such as those with rheumatoid arthritis, HIV, or organ transplants. Researchers will compare giving both vaccines at the same time versus one month apart, and also t…

This study checks if a simple finger prick (dried blood spot) can measure inflammation markers as well as a standard blood draw from a vein. About 50 adults who are getting a vaccine or have a planned stressor will give both types of samples. The goal is to see if the finger-pric…

This study looks at whether dexamethasone, a drug often given during mastectomy to prevent nausea, might actually increase the chance of long-term pain after surgery. Researchers will follow 170 women for three months after their operation to compare pain levels between those who…