Institut Curie

This early-stage trial tested the drug olaparib (a PARP inhibitor) given alongside radiation therapy for people with triple-negative breast cancer that is advanced or has come back. The main goal was to find the safest dose of olaparib when used with radiation, and to watch for s…

This study tested the safety and effectiveness of a drug called trastuzumab, given directly into the spinal fluid, for people with HER2-positive breast cancer that had spread to the lining of the brain (carcinomatous meningitis). The study had two parts: first, finding the safest…

This early-phase study tested adding the immunotherapy drug nivolumab to standard chemoradiation for 21 people with locally advanced cervical cancer. The main goal was to check safety and find the right dose. Researchers also looked at how well the treatment shrank tumors. The ap…

This study tested whether adding the targeted drug cetuximab to standard radiation and cisplatin chemotherapy could help control cervical cancer better than radiation and cisplatin alone. It involved 76 patients with stage IB2 to IIIB cervical cancer that could not be removed by …

This study looked at women with metastatic breast cancer whose original tumors tested negative for HER2, a protein that some breast cancer drugs target. Researchers used a blood test to find cancer cells that had extra copies of the HER2 gene. If found, the women were treated wit…

This study tested two different ways of giving radiation to children and teens (ages 4–21) with a standard-risk brain tumor called medulloblastoma. The goal was to see if giving smaller, more frequent doses (hyperfractionated) works better than the usual schedule at controlling t…

This study tested whether using a special PET scan (FAZA) to find oxygen-starved, treatment-resistant cells in chordoma tumors could improve proton therapy. 64 adults with skull base, spine, or sacral chordomas received surgery followed by proton therapy guided by the scan. The g…

This study tested a more intense chemotherapy plan for people aged 2 to 50 with Ewing sarcoma that has spread beyond the lungs. The goal was to see if this approach could help more patients become cancer-free for at least 18 months. The treatment combined high-dose chemotherapy w…

This study tested a combination of three drugs (pomalidomide, cyclophosphamide, and dexamethasone) in 100 adults with multiple myeloma whose cancer came back after their first treatment. Participants had previously received a standard three-drug regimen. The goal was to see how m…

This study looked at urine and blood samples from 80 men, including those with prostate cancer, suspected cancer, or healthy donors. Researchers analyzed long non-coding RNA in these samples to see if they could serve as biomarkers for diagnosis and monitoring. The goal is to dev…

This study tested a simple, rapid PSA blood test that gives results in minutes, comparing it to the standard lab PSA test. Researchers enrolled 94 men with prostate cancer or benign prostate disease. The goal was to see if the quick test is accurate enough for screening. If it wo…

This study tested whether a special 3D ultrasound technique called shear wave elastography can predict how well breast cancer responds to chemotherapy before surgery. Researchers measured tumor stiffness in 140 women with locally advanced breast cancer at several points during tr…

This study tested whether injecting a local anesthetic (ropivacaine) into the surgical area during breast cancer surgery could prevent chronic breast pain that sometimes follows. Researchers compared 260 patients who received either ropivacaine or a placebo (salt water) during su…

This study looked at whether starting supportive care early helps patients with metastatic uveal melanoma, a rare eye cancer that has spread. 162 adults were split into two groups: one received standard cancer care plus early supportive care visits, the other received standard ca…

This study tested a morphine gel on 17 patients with severe skin pain from radiation therapy for perineal tumors. The goal was to see if the gel could reduce pain and help patients continue their radiation without breaks. Results are based on patient reports of pain changes and h…

This study tested two types of nerve blocks (ESP and PVB) given before breast cancer surgery to see which one controls pain better right after the operation. It involved 292 women having breast surgery. The main goal was to compare how many patients needed morphine in the first t…

This study tested whether a special dressing (Hydrosorb) works better than a water-based spray for treating skin irritation caused by radiation therapy in breast cancer patients. 278 women with early signs of radiation rash took part. The goal was to see which treatment better pr…

This study tested whether a numbing injection (ropivacaine) around chest nerves before breast cancer surgery reduces pain right after the operation. 182 women having a lumpectomy with sentinel node biopsy took part. The goal was to see if fewer patients needed strong painkillers …

This study looked at whether a day hospital focused on integrated palliative care can improve quality of life for adults with advanced cancer. 144 patients took part. The goal was to see if this approach helps patients feel better and supports their caregivers.

This study tested a method to identify tumor mutations and measure immune cell responses in the lymph nodes of 25 patients with breast cancer or melanoma. Researchers took blood samples and used two techniques to find which mutations trigger T-cell activity. The goal was to see i…

This study tested whether breast cancer has a unique smell that can be captured by a special odor-sensing material. Researchers collected samples from the hands and tumors of 35 women before and after breast cancer surgery. The goal was to see if the sensor could isolate cancer-r…

This study looked at whether measuring circulating tumor cells (CTCs) in the blood can help doctors decide when to switch chemotherapy for women with metastatic breast cancer that has worsened after two prior treatments. The trial involved 265 women and compared standard care wit…

This study tested whether temporarily blocking and then releasing blood flow to a skin cancer (basal cell carcinoma) could increase blood flow to the tumor. Twelve adults with this type of skin cancer had their tumor's blood supply briefly clamped during surgery, and blood flow w…

This study looked at whether measuring tumor DNA in the blood can help doctors understand how well surgery worked for uveal melanoma that spread to the liver. About 60 adults with this condition had blood samples taken before and after surgery. The goal was to see if changes in t…

This study looked at whether giving a booklet with suggested questions helps cancer patients or their families ask more during palliative care visits. About 121 adults with advanced cancer took part. The goal was to see if the booklet improves communication and understanding of p…

This study looked at how women feel and think after getting a personalized estimate of their breast cancer risk. Researchers used a special computer model (BOADICEA) to give each woman a risk score based on her genes. The goal was to see if this personalized information changes h…

This study examined 130 patients with chronic wounds to see if biofilm (a slimy layer of bacteria) is present. Researchers used special microscopes to detect biofilm and compared findings with patient health records and wound care details. The goal was to learn more about how bio…

This study aimed to develop a blood test that can detect tiny bits of tumor DNA in patients with metastatic choroidal melanoma, a rare eye cancer that has spread. Researchers tested blood samples from 40 adults to see if the test could reliably find cancer DNA. The goal was to cr…

This study aims to create a communication tool to help doctors and patients discuss when cancer stops responding to treatment. Researchers interviewed 128 people, including patients with certain breast cancers, metastatic uveal melanoma, and parents of children with cancer, along…

This study followed nearly 2,000 healthy hospital and non-hospital workers over 12 months to see if they had antibodies against the COVID-19 virus. Participants gave blood samples at several time points, and some also had nasal swabs. The goal was to understand how long antibodie…

This study tested whether choosing cancer drugs based on the genetic makeup of a patient's tumor works better than standard treatment. It included 742 adults with advanced solid tumors that had stopped responding to usual therapies. Patients were randomly assigned to receive eith…