Institut Curie

This study tests two ways to treat retinoblastoma, a childhood eye cancer, while trying to save the eye and vision. One part compares two types of artery-directed chemotherapy (one with two drugs, one with one) to see which better preserves the eye. The other part looks at how we…

This study tests a combination of two drugs, tucatinib and trastuzumab, in people with a specific type of advanced breast cancer that has a mutation in the HER3 gene. The cancer must be HER2-negative and has already been treated with at least two prior chemotherapies. The goal is…

This study is testing a new type of PET scan called FAPI PET to see if it can find pancreatic cancer progression or return earlier than current tests. About 35 adults with pancreatic cancer will get this scan along with their usual exams. The goal is to improve early detection an…

This study is testing whether a new type of PET scan (68Ga-FAPI-46) can predict if triple-negative breast cancer will completely respond to chemotherapy plus immunotherapy before treatment begins. About 60 women with early-stage, high-risk breast cancer will get the scan before s…

This study tests whether a special solution (taurolidine) placed inside the catheter can prevent infections better than the standard saltwater solution. About 148 children with cancer who need a central catheter will take part. The goal is to see if the taurolidine lock reduces t…

This study compares opioid-free anesthesia using dexmedetomidine and lidocaine to standard opioid-based anesthesia in 158 women undergoing breast reconstruction after cancer. The goal is to see if the opioid-free approach reduces morphine use and side effects in the first 48 hour…

This study collects tumor and blood samples from over 1,000 people with certain cancers (ovarian, breast, head and neck, cervical, vulva, and sarcoma). Researchers will analyze the samples to find links between genetic changes, the immune system, and how the cancer behaves. Parti…

This study looks at 500 adults starting their first chemotherapy treatment with a chest port (a small device placed under the skin to deliver medicine). The goal is to find out how often skin reactions like itching or redness happen at the dressing site. Researchers will also exp…

This study is testing whether a liquid biopsy (a blood test that looks for cancer DNA) can predict how well immunotherapy works in people with advanced lung cancer. Researchers will track changes in tumor DNA levels before and after six weeks of treatment. The goal is to see if t…

This Phase 3 trial tests whether a special PET scan (EstroTEP) and blood tests can help doctors choose the best second-line treatment for people with ER-positive, HER2-negative metastatic breast cancer. The study will enroll 300 participants and compare outcomes when treatment is…

This study aims to find and measure special immune cells that target cancer in 300 patients whose immune system may be reacting to their tumor or treatment. Researchers will collect blood cells through a process called lymphapheresis and use advanced tests to detect these cells. …

This study is collecting blood samples from up to 2050 cancer patients to look for tiny pieces of tumors, called biomarkers, in the blood. The goal is to see how often these markers can be detected. Participation does not change standard cancer care or treatments.

This study looks at how many breast and lung cancer patients have a strong, ongoing fear that their cancer will return. Researchers will survey 200 patients and interview 40 of them to understand their feelings and whether they get enough support. The goal is to find better ways …

This study follows 700 people with uveal melanoma (a rare eye cancer) who are at high risk of the cancer spreading to the liver. Researchers will collect blood samples and medical data to find early signs of metastasis. The goal is to personalize follow-up care based on each pers…

This study looks at whether training for doctors and educational workshops for patients can increase the use of enteral nutrition (feeding through a tube) in cancer patients who are malnourished. About 80 adults with cancer who need this type of nutrition will take part. The goal…

This study tests whether a genetic test on a liver biopsy can help doctors pick the most effective first chemotherapy for people with advanced pancreatic cancer. About 85 participants will have their treatment chosen based on these genetic markers. The goal is to see if this pers…

This study looks at whether regular blood tests (ctDNA monitoring) combined with a special type of PET scan can detect the return of triple negative breast cancer earlier than standard methods. About 450 women who finished treatment for early-stage triple negative breast cancer w…

This study looks at whether a structured program can help more high-risk smokers get a first lung cancer screening with a CT scan. About 500 people aged 50 to 74 who smoke or recently quit will join. The goal is to see if a dedicated network makes screening easier and more effect…

This study looks at the immune cells and genetic changes inside thymic tumors. Researchers will analyze tumor tissue and blood from 50 adults who have not yet been treated. The goal is to better understand these rare tumors and identify potential new targets for future treatments…

This study looks at genetic changes in families to figure out which ones truly increase cancer risk. Researchers will analyze DNA from 11,000 people, including those with certain gene variants and their relatives. The goal is to improve genetic counseling and help doctors decide …