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Massive study aims to decode cancer genes for better family counseling

NCT ID NCT01689584

Knowledge-focused Sponsor: Institut Curie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 02, 2026 · Updated 2 times

Summary

This study looks at genetic changes in families to figure out which ones truly increase cancer risk. Researchers will analyze DNA from 11,000 people, including those with certain gene variants and their relatives. The goal is to improve genetic counseling and help doctors decide if preventive surgeries are needed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 11,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2012

Expected to finish

Jan 2038

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Index cases: * A person carrying a variant of interest in a gene analyzed in a diagnostic setting by one of the laboratories within the Genetics and Cancer Group (GGC)-Unicancer network, classified as class 3, 4 or hypomorphic class 5, and selected by the national expert group for the gene concerned. * Age ≥ 18 years. * Signed written inform consent "index case" Related parties: * Any relative of an index case with cancer * Any relative without cancer related to an index case, selected by the investigators, according to family structure and degree of related compared to the index case * For class 4 and hypomorphic class 5 variants; relatives currently undergoing analysis or having already obtained a test result for the variant of interest as part of clinical care. * Age ≥ 18 years * Information and signature of the informed consent "selected relatives" Exclusion Criteria: * Minors * Persons deprived of liberty or under guardianship (including curators). * Absence of signed written inform consent

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Conditions

The condition(s) this trial relates to.

hereditary neoplastic syndrome inherited disease susceptibility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gene mutation-related cancer Genetic predisposition

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    61 sites in 5 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CH Simone VEIL

    RECRUITING

    Troyes, 10003, France

  • CHD Vendée

    NOT_YET_RECRUITING

    La Roche-sur-Yon, 85925, France

  • CHRU Caremeau

    RECRUITING

    Nîmes, 30029, France

  • CHU Amiens - Hôpital Nord

    RECRUITING

    Amiens, 80054, France

  • CHU Arnaud de Villeneuve

    RECRUITING

    Montpellier, 34295, France

  • CHU Besançon

    RECRUITING

    Besançon, 25030, France

  • CHU Bretonneau

    RECRUITING

    Tours, 37044, France

  • CHU Dupuytren

    RECRUITING

    Limoges, 87042, France

  • CHU La Milétrie

    RECRUITING

    Poitiers, 86021, France

  • CHU La Timone

    RECRUITING

    Marseille, 13385, France

  • CHU Morvan de Brest

    RECRUITING

    Brest, 29200, France

  • CHU Nancy - Hôpital Brabois

    RECRUITING

    Vandœuvre-lès-Nancy, 54511, France

  • CHU Rennes - Hôpital Sud

    NOT_YET_RECRUITING

    Rennes, 35203, France

  • CHU Saint Etienne

    RECRUITING

    Saint-Etienne, 42055, France

  • CHU Sud Réunion Saint-Pierre

    RECRUITING

    Saint-Pierre, 97410, Reunion

  • CHU de Dijon

    RECRUITING

    Dijon, 21079, France

  • CHU de Fort de France

    RECRUITING

    Fort-de-France, 97261, Martinique

  • CHU de Grenoble

    RECRUITING

    Grenoble, 38043, France

  • CHU de Pointe à Pitre

    RECRUITING

    Pointe-à-Pitre, 97110, Guadeloupe

  • CHU de Reims

    RECRUITING

    Reims, 51092, France

  • CHU de Rouen

    RECRUITING

    Rouen, 76031, France

  • CLCC Paul Strauss

    RECRUITING

    Strasbourg, 67033, France

  • Centre Alexis Vautrin

    WITHDRAWN

    Vandœuvre-lès-Nancy, 54511, France

  • Centre Antoine Lacassagne

    RECRUITING

    Nice, 06189, France

  • Centre Catherine de Sienne

    RECRUITING

    Nantes, 44202, France

  • Centre Eugène Marquis

    RECRUITING

    Rennes, 35042, France

  • Centre François Baclesse

    RECRUITING

    Caen, 14076, France

  • Centre Hospitalier Georges Renon

    RECRUITING

    Niort, 79021, France

  • Centre Hospitalier Hôtel Dieu

    RECRUITING

    Chambéry, 73011, France

  • Centre Hospitalier Intercommunal Poissy -Saint Germain-en-Laye

    NOT_YET_RECRUITING

    Poissy, 78303, France

  • Centre Hospitalier Jacques Coeur

    RECRUITING

    Bourges, 18020, France

  • Centre Hospitalier Territorial Gaston Bourret

    NOT_YET_RECRUITING

    Noumea, 98849, New Caledonia

  • Centre Hospitalier d'Angoulème

    RECRUITING

    Angoulême, 16959, France

  • Centre Hospitalier de Bastia

    NOT_YET_RECRUITING

    Bastia, Corsica, 20604, France

  • Centre Hospitalier de Valence

    RECRUITING

    Valence, 26953, France

  • Centre Jean Perrin

    RECRUITING

    Clermont-Ferrand, 63011, France

  • Centre Léon Bérard

    RECRUITING

    Lyon, 69373, France

  • Centre Oscar Lambret

    RECRUITING

    Lille, 59000, France

  • Chru Lille

    RECRUITING

    Lille, 59037, France

  • Groupe Hospitalier La Rochelle-Ré-Aunis

    RECRUITING

    La Rochelle, 17019, France

  • Groupe Hospitalier Pellegrin

    RECRUITING

    Bordeaux, 33076, France

  • Groupe Hospitalier Pitié-Salpêtrière

    RECRUITING

    Paris, 75013, France

  • Gustave Roussy

    RECRUITING

    Villejuif, 94805, France

  • HEGP

    RECRUITING

    Paris, 75908, France

  • Hopital de Hautepierre - Hôpital Universitaire

    RECRUITING

    Strasbourg, 67200, France

  • Hospices Civils de Lyon

    RECRUITING

    Lyon, 69229, France

  • Hôpital Civil de Colmar

    NOT_YET_RECRUITING

    Colmar, 68024, France

  • Hôpital Flaubert

    RECRUITING

    Le Havre, 76083, France

  • Hôpital Saint-Antoine

    RECRUITING

    Paris, 75012, France

  • Hôpital Saint-Louis

    RECRUITING

    Paris, 75475, France

  • Hôpital Tenon

    RECRUITING

    Paris, 75020, France

  • Hôpital de la Source

    RECRUITING

    Orléans, 45067, France

  • ICC Courlancy

    RECRUITING

    Reims, 51100, France

  • ICO - Centre Paul Papin

    RECRUITING

    Angers, 49933, France

  • ICO - Centre René Gauducheau

    RECRUITING

    Saint-Herblain, 44804, France

  • Institut Bergonié

    RECRUITING

    Bordeaux, 33076, France

  • Institut Claudius Regaud - IUCT - Oncopole

    RECRUITING

    Toulouse, 31059, France

  • Institut Curie - Paris site

    RECRUITING

    Paris, Île-de-France Region, 75005, France

  • Institut Curie - Saint-Cloud site

    RECRUITING

    Saint-Cloud, Haut de Seine, 92210, France

  • Institut Jean Godinot

    RECRUITING

    Reims, 51100, France

  • Institut Paoli Calmettes

    RECRUITING

    Marseille, 13009, France

  • Institut Sainte-Catherine

    RECRUITING

    Avignon, 84918, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.