Institut Curie

This study tests a combination of two targeted drugs, tucatinib and trastuzumab, in people with advanced breast cancer that has a specific genetic change (HER3 mutation) but does not have high levels of the HER2 protein. Participants have already tried at least two other chemothe…

This study looks at whether giving radiation therapy after surgery can stop thymoma (a rare chest tumor) from returning in patients with stage II or III disease. About 314 adults aged 18-75 who had the tumor completely removed will be randomly assigned to receive radiation or jus…

This study tests two treatment strategies for children with retinoblastoma, a rare eye cancer. One part compares two types of chemotherapy given directly into the eye artery to see which better saves the eye. The other part looks at how well vision is preserved with standard IV c…

This study is testing whether a new type of PET scan (68Ga-FAPI-46) can predict if triple-negative breast cancer will completely respond to chemotherapy plus immunotherapy before surgery. About 60 women with early-stage, high-risk breast cancer will receive the scan before starti…

This study tests a new type of PET scan called FAPI PET to see if it can find pancreatic cancer progression or return earlier than current scans. About 35 adults with pancreatic cancer will get FAPI PET scans at several points during their treatment. The goal is to improve early …

This study tests whether a taurolidine lock solution, placed inside the catheter when not in use, can prevent infections better than a standard saline lock. About 148 children with cancer who need a central catheter will take part. The study is double-blind, meaning neither the p…

This study tests whether avoiding opioids during breast reconstruction surgery can reduce the need for strong painkillers afterward. About 158 women will be randomly assigned to receive either opioid-free or standard opioid-based anesthesia. The goal is to see if the opioid-free …

This study looks at whether teaching cancer patients and their healthcare providers about tube feeding (enteral nutrition) can increase its use when needed. Many patients who could benefit from tube feeding don't get it, even though it's recommended. The study will enroll 80 adul…

This study tests whether a special PET scan (EstroTEP) and blood tests can help doctors pick the right second-line treatment for people with ER-positive, HER2-negative breast cancer that has spread. About 300 participants will be assigned to either hormone therapy or chemotherapy…

This study looks at the immune cells and genetic changes in thymic epithelial tumors (TETs). Researchers will analyze tumor tissue and blood from 50 adults who have not yet been treated. The goal is to better understand these rare tumors, not to test a new treatment.

This study follows 700 people with uveal melanoma (a rare eye cancer) who are at high risk of the cancer spreading to the liver. Researchers will use blood tests to look for early signs of liver metastases and tailor follow-up care to each person's risk. The goal is to improve ea…

This study is collecting blood samples from up to 2050 cancer patients to look for tiny pieces of tumors (called biomarkers) in the blood. The goal is to learn how well blood tests can detect these markers, not to change or test any treatments. Participants will give blood sample…

This study looks at how common severe fear of cancer recurrence is among people treated for breast or lung cancer. Researchers will survey 200 patients and interview 40 of them to understand their experiences and what kind of support they need. The goal is to improve how hospital…

This study tracks 500 adults starting their first chemotherapy through a chest port. The goal is to measure how often skin reactions like itching or redness happen at the dressing site. Researchers will also look for factors that raise the risk of these reactions, such as the typ…

This study is collecting tumor, blood, and plasma samples from over 1,000 people with certain cancers (ovarian, breast, head and neck, cervical, vulva, and sarcoma). The goal is to find new markers that link tumor genetics and immune response to how the disease behaves. Participa…

This study tests whether using genetic signatures from a liver biopsy can help doctors choose the best first chemotherapy for people with advanced pancreatic cancer. About 85 participants will have their treatment selected based on these genetic markers. The goal is to see if thi…

This study aims to find and measure special immune cells that can recognize and attack cancer. Researchers will collect blood samples from 300 cancer patients whose immune system may be reacting to their disease or treatment. The goal is to better understand how the body fights c…

This study looks at whether regular blood tests for cancer DNA, followed by a special PET scan if the DNA is found, can help detect the return of triple-negative breast cancer earlier than usual scans. About 450 women who finished treatment for early-stage triple-negative breast …

This study is testing whether a liquid biopsy (a simple blood test) can predict how well first-line immunotherapy works in people with advanced non-small cell lung cancer. Researchers will track genetic changes in the blood before and during treatment to see if they match tumor s…

This study is for people with advanced breast cancer whose current treatment has stopped working. Researchers will take a small sample of the tumor and grow it in the lab to create a 'tumorogram'—a test that shows which drugs might work best. Based on the results, doctors will ch…