Institut Curie

This early-phase study tested whether adding the immunotherapy drug nivolumab to standard chemoradiation is safe for people with locally advanced cervical cancer. Twenty-one adults took part, receiving nivolumab alongside radiation and cisplatin, followed by up to six months of n…

This study tested a combination of three drugs (pomalidomide, cyclophosphamide, and dexamethasone) in 100 adults with multiple myeloma whose cancer returned after initial treatment. Participants had previously received standard first-line therapy. The goal was to see how well the…

This study tested whether adding the targeted drug cetuximab to standard radiation and chemotherapy (cisplatin) helps control cervical cancer better than radiation and cisplatin alone. It included 76 patients with stage IB2 to IIIB cervical cancer that could not be surgically rem…

This study tested a more intense chemotherapy plan for people aged 2 to 50 with Ewing sarcoma that has spread to bones or bone marrow (not just lungs). The goal was to see if this approach could help more patients become cancer-free for at least 18 months. 45 participants receive…

This study tested the drug trastuzumab, given directly into the spinal fluid, for people with HER2-positive breast cancer that spread to the lining of the brain (carcinomatous meningitis). The first part found the safest dose, and the second part checked if it could slow down ner…

This early-phase trial tested the safety of combining the drug olaparib with radiation therapy in 24 women with advanced triple-negative breast cancer. The main goal was to find the highest safe dose of olaparib when given with radiation. The study focused on patients whose cance…

This study tested whether using a special PET scan (FAZA PET/CT) to find oxygen-starved tumor cells can improve radiation treatment for chordoma, a rare bone cancer. 64 adults with chordoma in the skull base, spine, or sacrum received surgery followed by proton therapy guided by …

This study looked at 155 people with metastatic breast cancer whose original tumors were HER2-negative. Researchers checked their blood for cancer cells that had extra HER2 genes. If found, participants received the drug T-DM1. The goal was to see if these hidden HER2-positive ce…

This study tested whether giving radiation in many small doses (hyperfractionated) works better than the usual schedule for children and teens with standard-risk medulloblastoma, a type of brain tumor. The trial included 52 participants aged 4 to 21. The goal was to see if the ne…

This study tested a simple, rapid PSA test that uses whole blood to see if it works as well as the standard lab test for prostate cancer screening. Researchers compared results from 94 patients with prostate cancer or benign prostate disease. The goal was to see if the quick test…

This study tested two types of nerve blocks (ESP and PVB) given before breast cancer surgery to see which one controls pain better right after the operation. About 292 women took part. The main goal was to see how many needed morphine in the first two hours after surgery. The res…

This study looked at whether adding supportive care early on helps meet the psychological needs of people with metastatic uveal melanoma, a rare eye cancer that has spread. 162 adults took part, receiving either standard cancer care alone or with early supportive care. The goal w…

This study tested whether a numbing injection (ropivacaine) around chest nerves before breast cancer surgery reduces pain right after the operation. 182 women having a lumpectomy with lymph node removal took part. The goal was to see if fewer patients needed strong pain relievers…

This study tested a special bandage (Hydrosorb) against a water spray to manage skin burns from radiation therapy in 278 women with breast cancer. The goal was to prevent the burns from getting worse and avoid interrupting cancer treatment. The study looked at pain, skin color ch…

This study tested whether injecting a local anesthetic (ropivacaine) during breast cancer surgery could prevent chronic pain that sometimes lingers for months. Researchers compared pain levels three months after surgery in 260 women who either received the injection or a placebo.…

This study looked at whether a day hospital focused on integrated palliative care can improve quality of life for adults with advanced cancer. 144 patients took part. The goal was to see if this approach helps patients feel better and supports their caregivers.

This study looked at whether a special morphine gel can help with pain from severe radiation burns on the skin around the genitals and anus. Researchers reviewed the records of 17 patients who used the gel. The goal was to see if the gel reduced pain and if it helped patients avo…

This study tested a method to identify immune cells (T cells) that recognize unique mutations in tumors from breast cancer or melanoma patients. Researchers looked at lymph nodes invaded by cancer to see if they could find and measure these cells. The goal was to see if the metho…

This study tested whether giving a booklet-question list to people with advanced cancer or their families helps them ask more questions during a palliative care visit. About 121 participants were involved. The goal was to see if the booklet improves communication about prognosis …

This study tested whether a special 3D ultrasound technique (called shear wave elastography) can accurately predict how well breast tumors respond to chemotherapy before surgery. Researchers measured tumor stiffness in 140 women with locally advanced breast cancer at several poin…

This study looked at how healthy women with a family history of breast cancer felt after receiving a personalized risk estimate using the BOADICEA model. Researchers surveyed 405 women to measure their understanding and emotional response. The goal was to improve how genetic risk…

This study involved 40 adults with metastatic choroidal melanoma, a rare eye cancer that has spread. Researchers developed and tested a blood test to detect circulating tumor DNA, which could help monitor the disease without needing a tissue biopsy. The goal was to see if the tes…

This study followed nearly 2,000 healthy employees from two research institutes to see how their bodies produced antibodies against the COVID-19 virus over time. Participants gave blood samples at the start and then again at several points over a year. The goal was to learn about…

This study looked at 130 patients with chronic wounds to find out if biofilm (a slimy layer of bacteria) is present. Researchers used special microscopes to examine wound samples and compared findings with medical records. The goal was to better understand how biofilm affects wou…

This study tested whether temporarily stopping blood flow to a skin cancer (basal cell carcinoma) and then releasing it causes a surge in blood flow through the tumor. Researchers used a special camera to measure blood flow in 12 patients during surgery. The goal was to see if th…

This study tested whether choosing cancer drugs based on the genetic profile of a patient's tumor could work better than standard chemotherapy. 742 adults with advanced solid tumors that had stopped responding to treatment were randomly assigned to either a targeted therapy match…

This study tested whether breast cancer has a unique smell that can be captured by a special polymer. Researchers collected samples from the hands and tumors of 35 women before and after breast cancer surgery. The goal was to see if a sensitive technique could isolate cancer-rela…

This study collected urine and blood samples from 80 men, including those with prostate cancer, those with suspected cancer, and healthy volunteers. The goal was to find new biomarkers (biological clues) that could help diagnose prostate cancer or predict how it will progress, wi…

This study looked at 60 people with uveal melanoma that spread to the liver and who were eligible for surgery to remove it. Researchers measured circulating tumor DNA in the blood before and after surgery to see if it could predict whether all cancer was removed. The goal was to …

This study looked at whether checking for cancer cells in the blood (circulating tumor cells) can help doctors decide when to switch chemotherapy in women with metastatic breast cancer. 265 women who had already tried two chemotherapies took part. The goal was to see if this appr…

This study aimed to create a communication tool to help doctors and patients talk about cancer that stops responding to treatment. Researchers interviewed 128 people, including patients with certain breast cancers, metastatic uveal melanoma, and parents of children with cancer, a…