New Scan-Guided proton therapy aims to stop rare bone tumors

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Typical chordoma and chondroid chordoma of the skull base, spine or chordoma of sacral region * Patient undergoing an additional or exclusive radiotherapy (Photontherapy and/or Prothontherapy) * Age ≥ 18 years old * ECOG performance status 0 to 2 * Satisfying biological functions 28 days before inclusion : 1. Haemoglobin ≥ 9 g/dL 2. Neutrophils ≥ 1500/mm3 3. Platelets ≥ 100 000/mm3 4. ASAT, ALAT, GGT, PAL ≤ 1.5 N, bilirubin ≤ 40 μmol/L, LDH ≤ 1.5 N 5. Creatininemia \< 1.5 N * Satisfying vital cardiac and respiratory functions * Neurologic functions well stabilised * Effective contraception for women of childbearing age during the the protontherapy treatment and during the month following the end of treatment. A pregnancy test shall be negative at inclusion. * Patient covered by health insurance * Patient provided with information and signature of informed consent. Exclusion Criteria: * Dedifferentiated chordomas, chondrosarcoma * History of cancer (except cutaneous basocellular epithelioma or epithelioma of the uterine cervix) having recurred in the 5 years preceding entry in the trial and no relapse in the last 3 years * Metastatic patient * History of brain radiation therapy, or base of the skull or spinal segments to be treated * Contraindications to radiotherapy * Contraindications to PET/CT examinations \[18F\] Fluorodexoxyglucose (FDG) and \[18\]FAZA * Associated pathology likely to prevent the patient from receiving treatment, * Incompatible treatment with the inclusion in the study (oxygen therapy, EPO, anti-vascular treatments, anti-angiogenic treatments) * Patient already included in another therapeutic trial with an experimental medication, * Patient currently nursing, * Persons deprived of their liberty, or under guardianship, * Impossibility of undergoing the trial's medical follow-up for geographical, social or psychological reasons.