Institut Curie

This study tests a combination of two immunotherapy drugs (tiragolumab and atezolizumab) plus chemotherapy in people with triple negative breast cancer. It includes two groups: those with early-stage cancer and those with advanced cancer that has spread. The goal is to see if the…

This study tests whether combining two drugs, pembrolizumab and lenvatinib, can help people with a rare eye cancer (uveal melanoma) that has spread. About 51 adults will take part, split into two groups: those who have not had a prior treatment called tebentafusp, and those who h…

This early-phase trial tests a new drug called PEP-010 in people with metastatic solid tumors that have not responded to standard treatments. The study first gives PEP-010 alone, then in combination with chemotherapy drugs paclitaxel or gemcitabine. It aims to find a safe dose an…

This study tests whether a combination of chemotherapy drugs (VP16 and carboplatin) followed by local heat therapy can control retinoblastoma, a rare eye cancer in children, without needing to remove the eye or use radiation. It involves 133 children with different stages of the …

This study looks at whether giving chemotherapy (and sometimes radiation) after removing the eye can prevent retinoblastoma from coming back outside the eye. It involves 195 children under 10 who had one eye removed for extensive retinoblastoma. The goal is to reduce relapses and…

This study tests adding either lenalidomide or ibrutinib to standard chemotherapy for adults aged 18-65 with newly diagnosed primary central nervous system lymphoma (a rare brain cancer). The goal is to improve treatment response before a stem cell transplant. The trial first fin…

This study checks if a simple blood test that looks for tumor DNA can detect the return of HPV-positive pelvic cancers (like cervical or anal cancer) earlier than usual scans. About 172 people who finished treatment and are in follow-up will give blood samples. The goal is to see…

This study looks at whether a special decision-making tool can help doctors and patients with advanced non-small cell lung cancer choose more wisely about continuing or stopping cancer treatments. The goal is to see if using this tool reduces the number of patients receiving aggr…

This study looks at whether regular MRI scans can find new head, neck, or brain cancers early in people with hereditary retinoblastoma who were treated with radiation. About 88 participants who had radiation at least 5 years ago and are now 7 or older will get MRI screenings. The…