Institut Curie

This study tests whether adding lenalidomide or ibrutinib to standard chemotherapy (R-MPV) can improve outcomes for adults aged 18-65 with newly diagnosed primary central nervous system lymphoma. The trial has two parts: first, finding the safest dose, then randomly assigning pat…

This study looks at whether giving chemotherapy (and sometimes radiation) after removing the eye can prevent retinoblastoma from coming back in children. About 195 children with advanced retinoblastoma in one eye took part. The goal is to see if this extra treatment reduces the c…

This early-phase trial tests a new drug called PEP-010 in people with advanced solid tumors that have spread. The study checks if PEP-010 is safe alone or with chemotherapy (paclitaxel or gemcitabine). About 57 adults with metastatic pancreatic, ovarian, or other solid cancers wi…

This study tests a combination of two immunotherapy drugs (tiragolumab and atezolizumab) plus chemotherapy in 81 women with triple negative breast cancer. It includes two groups: those with early-stage cancer and those with advanced (metastatic) cancer. The goal is to see if the …

This study tests whether combining chemotherapy with local treatments can save the eyes of children with retinoblastoma, a rare eye cancer. About 133 children with different stages of the disease received chemotherapy drugs followed by heat therapy or other local treatments. The …

This study tests two drugs, pembrolizumab and lenvatinib, in people with metastatic uveal melanoma, a rare eye cancer that has spread. The goal is to see if the combination can slow tumor growth. The trial includes two groups: those who have not had a prior treatment called Teben…

This study looks at whether a simple blood test that finds tiny bits of tumor DNA (ctDNA) can detect the return of HPV-positive pelvic cancers (like cervical or anal cancer) earlier than usual scans or exams. About 172 people who have already been treated for these cancers and ar…

This study looks at whether a special decision-making tool can help doctors and patients with advanced non-small cell lung cancer decide when to stop cancer treatments. The goal is to reduce the number of patients receiving chemotherapy or other treatments in their last days of l…

This study looks at whether regular MRI scans can find new head, neck, or brain cancers early in people with hereditary retinoblastoma who had radiation therapy. About 88 participants who are at least 7 years old and had radiation 5+ years ago will get MRI screenings. The goal is…