Institut Curie

This study tests two ways to treat retinoblastoma, a childhood eye cancer, while trying to save the eye and vision. One part compares two types of artery-directed chemotherapy (one with two drugs, one with one) to see which better preserves the eye. The other part looks at how we…

This study tests a combination of two drugs, tucatinib and trastuzumab, in people with a specific type of advanced breast cancer that has a mutation in the HER3 gene. The cancer must be HER2-negative and has already been treated with at least two prior chemotherapies. The goal is…

This study tests whether a new type of PET scan (68Ga-FAPI-46) can predict if triple-negative breast cancer will completely respond to chemotherapy plus immunotherapy before surgery. About 60 women with early-stage, high-risk breast cancer will receive the scan before starting tr…

This study is testing a new type of PET scan called FAPI PET to see if it can detect pancreatic cancer progression or return earlier than current tests. About 35 adults with pancreatic cancer that hasn't spread will get this scan at several points during their treatment. The goal…

This study tests whether a special solution (taurolidine) placed inside the catheter can prevent infections better than the standard saltwater solution. About 148 children with cancer who need a central catheter will take part. The goal is to see if the taurolidine lock reduces t…

This study tests whether avoiding opioids during breast reconstruction surgery can reduce the need for morphine afterward. About 158 women having free flap breast reconstruction will be randomly assigned to receive either opioid-free or standard opioid anesthesia. The goal is to …

This study tests whether a genetic test on a liver biopsy can help doctors pick the most effective first chemotherapy for people with advanced pancreatic cancer. About 85 participants will have their treatment chosen based on these genetic markers. The goal is to see if this pers…

This study looks at whether regular blood tests (ctDNA monitoring) combined with a special type of PET scan can detect the return of triple negative breast cancer earlier than standard methods. About 450 women who finished treatment for early-stage triple negative breast cancer w…

This study looks at whether a structured program can help more high-risk smokers get a first lung cancer screening with a CT scan. About 500 people aged 50 to 74 who smoke or recently quit will join. The goal is to see if a dedicated network makes screening easier and more effect…

This study tests whether a special PET scan (EstroTEP) and blood tests can help doctors choose the best second-line treatment for people with ER-positive, HER2-negative breast cancer that has spread. About 300 participants will be assigned to either hormone therapy or chemotherap…

This study is testing whether a liquid biopsy (a simple blood test) can predict how well immunotherapy works in people with advanced lung cancer. Researchers will track genetic changes in the blood over time and compare them to tumor responses on CT scans. The goal is to find a n…

This study looks at the immune cells and genetic changes inside thymic tumors. Researchers will analyze tumor tissue and blood from 50 adults who have not yet been treated. The goal is to better understand these rare tumors and identify potential new targets for future treatments…

This study looks at how many breast and lung cancer patients have a severe fear that their cancer will return. Researchers will survey 200 patients and interview 40 of them to understand their feelings and whether their support needs are being met. The goal is to improve how hosp…

This study collects blood samples from 2,050 cancer patients to look for tumor markers. It does not change the patient's standard care or treatment. The goal is to improve how we detect and understand cancer through simple blood tests.

This study looks at whether special training for healthcare providers and educational workshops for patients can increase the use of tube feeding (enteral nutrition) in cancer patients who need it. About 80 adults with cancer will take part. The goal is to see if these measures h…

This study follows 500 adults starting their first chemotherapy with a chest port. The goal is to count how many get skin reactions like itching or redness from the dressing. Researchers will also look for risk factors, such as the type of dressing or treatment, to help prevent t…

This study looks for special immune cells that target cancer in 300 patients whose immune system may be reacting to their tumor. Researchers will collect blood cells through a process called lymphapheresis to analyze these cells. The goal is to better understand how the immune sy…

This study looks at genetic changes in families to figure out which ones truly increase cancer risk. Researchers will analyze DNA from 11,000 people, including those with certain gene variants and their relatives. The goal is to improve genetic counseling and help doctors decide …

This study follows 700 people with uveal melanoma (a rare eye cancer) who have a high chance of the cancer returning. Researchers will use blood tests to look for early signs of liver spread and adjust follow-up care based on each person's risk. The goal is to improve early detec…

This study collects tumor and blood samples from over 1,000 people with certain cancers (ovarian, breast, head and neck, cervical, vulva, and sarcoma). Researchers will analyze these samples to find links between the tumor's genetic changes, the immune system, and how the disease…