Institut Bergonié

This completed Phase 2 trial tested whether combining an immunotherapy drug (durvalumab) with an epigenetic drug (tazemetostat) can control advanced solid tumors like pancreatic, colorectal, and soft-tissue sarcoma. The study enrolled 164 adults and measured how well the combo sh…

This phase 2 study tested whether combining two immune-boosting drugs, nivolumab and relatlimab, can control advanced soft-tissue sarcoma. Researchers enrolled 68 adults whose tumors had specific immune structures. The main goal was to see how many patients had their tumors stop …

This early-phase trial tested whether adding the drug olaparib to standard radiation therapy is safe for people with advanced soft-tissue sarcoma that cannot be removed by surgery. 41 participants received olaparib pills alongside daily radiation for about 7.5 weeks. The main goa…

This study tested a combination of two drugs—an immunotherapy (MK3475) and a low-dose chemotherapy (cyclophosphamide)—in 129 people with advanced sarcomas that had spread or could not be removed by surgery. The goal was to see if the treatment could shrink tumors or stop them fro…

This phase 2 trial tested the drug pazopanib against standard chemotherapy (vinblastine and methotrexate) in 72 people with progressive desmoid tumors. Desmoid tumors are non-cancerous but can be aggressive and hard to treat. The goal was to see if pazopanib could stop tumor grow…

This study tested a high-precision radiation therapy (helical tomotherapy) at a dose of 54 Gy before surgery in 48 patients with retroperitoneal liposarcoma, a rare cancer in the abdomen. The goal was to reduce the chance of the cancer coming back after surgery. Results showed th…

This study tested a procedure called radiofrequency ablation, which uses heat from a needle to destroy breast tumors, combined with hormone therapy. It included 21 elderly patients (over 70) who either declined or were not candidates for surgery. The main goal was to see if the c…

This study tested a combination of two chemotherapy drugs, trabectedin and cyclophosphamide, in 50 adults with advanced soft-tissue sarcomas that had already been treated. The goal was to find the safest dose and see if the combo could stop the cancer from growing for at least 6 …

This study tested whether adding the drug berzosertib to standard chemotherapy (gemcitabine) can help control a rare soft-tissue cancer called leiomyosarcoma. 58 adults with advanced or spreading disease took part. The goal was to see if the combination could stop or shrink tumor…

This early-phase trial tested a combination of two drugs—trabectedin and durvalumab—in 40 people with advanced soft-tissue sarcoma or ovarian cancer that had not responded to prior treatments. The main goal was to find the safest dose and check for side effects. Researchers also …

This study tested a different surgical approach called delayed coloanal anastomosis for people with medium or lower rectal cancer. The goal was to see if it lowers the chance of a dangerous leak where the colon is reconnected, and reduces the need for a temporary or permanent sto…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

This study looked at whether an MRI can detect breast cancer in women who have abnormal nipple discharge but normal mammograms and ultrasounds. 70 women with single-pore, non-milky, non-green discharge were given an MRI. The goal was to see how often a normal MRI meant no cancer …

This study looked at whether combining a PET scan with a special ultrasound-guided needle biopsy can accurately diagnose cancer in lymph nodes in the chest. 75 adults with suspicious lymph nodes on PET scans were enrolled. The goal was to see if this less invasive method could re…

This study tested whether injecting the numbing drug ropivacaine into the chest cavity can reduce severe pain after lung cancer surgery. 90 adults having a thoracotomy for cancer received either ropivacaine or a saltwater placebo every 6 hours for 2 days. The main goal was to see…

This study looked at whether giving nitrous oxide (laughing gas) during a spine procedure called vertebroplasty could lower pain and the need for morphine afterward. It included 39 adults who were already taking opioids for more than a month. The goal was to see if the gas could …

This study tested whether adding ketamine to general anesthesia helps reduce the need for morphine and lowers pain after breast cancer surgery. About 230 adults having mastectomy or lumpectomy took part. The goal was to see if ketamine could make recovery less painful and reduce …

This study looked at whether using telemedicine (video calls), connected watches, and symptom tracking apps can help women with advanced breast cancer who live far from their cancer center. Fifteen women took part, and researchers measured their quality of life after 6 and 12 mon…

This study looked back at over 2,000 patients with advanced soft tissue sarcoma to see what treatments they received and how well they did. Researchers analyzed data from a French database covering 1990 to 2013. The goal was to understand real-world care patterns and find factors…

This study looked at whether MRI scans can detect how well breast cancer responds to chemotherapy early in treatment. Sixteen women with invasive breast cancer received standard chemo before surgery, and their MRI results were checked by two radiologists. The goal was to see if M…

This study aims to find biological markers that can predict whether the drug trabectedin will work in patients with certain types of soft-tissue sarcoma. Researchers will collect tumor biopsies and blood samples from 29 participants before and during treatment. The goal is to use…

This study looked at whether adding a simple blood test (liquid biopsy) to the standard tissue biopsy helps find more genetic changes (EGFR mutations) in people with advanced non-small cell lung cancer. Over 500 patients who had not yet been treated took part. The goal was to see…

This study looked back at the medical records of 545 patients with bone tumors that had spread (metastatic). The goal was to see how these patients were treated in real life and what their outcomes were. The study focused on three types of bone tumors: osteosarcoma, Ewing sarcoma…

This study looked at 631 advanced melanoma patients treated with immune checkpoint inhibitors. Researchers wanted to see if the time until a patient needs their next treatment or dies (TNT-D) is a good stand-in for overall survival. The goal was to find a quicker way to measure h…

This study examined whether FDG-PET CT scans are more accurate than standard CT scans for staging muscle-invasive bladder cancer. Researchers reviewed records of 130 patients from two hospitals to compare PET CT results with actual surgical findings. The goal was to see if PET CT…

This study looked at whether small differences in certain genes (FCγRIIIA and FCγRIIA) can predict how well the drug cetuximab works in people with advanced head and neck cancers that cannot be cured by surgery or radiation. Researchers analyzed blood samples from 121 participant…

This completed observational study looked at 492 patients with metastatic gastrointestinal stromal tumors (GIST) in France between 1990 and 2018. Researchers analyzed real-world treatment patterns, including which drugs were used and in what order, and how many patients got acces…

This completed study looked at medical records from about 20,000 women with metastatic breast cancer in France. The goal was to see if earlier measures of treatment success, like time until the cancer worsens, could replace the standard measure of overall survival. By comparing t…

This study looked at whether using a contrast dye during ultrasound scans in the operating room helps surgeons better see and remove liver tumors that spread from colorectal cancer. About 68 adults with treatable liver metastases took part. The goal was to see if the enhanced ima…

This study developed a better way to calculate how many people are needed in clinical trials when patients have different risks or respond differently to treatment. Researchers analyzed data from 500 participants to improve trial design. The goal is to make future trials more rel…

This study tested a questionnaire called PO-BADO that helps doctors and nurses talk with cancer patients and their caregivers. Researchers checked if the questionnaire gives consistent and reliable results. 252 adults with cancer who have a caregiver support time took part. The g…

This study looked at how many hospital workers at Institut Bergonié had antibodies from a past COVID-19 infection. Over 500 staff members gave blood samples at the start, then again at 3 and 12 months. The goal was to track immune responses over time, especially among those carin…

This study looked at nearly 4,000 people with advanced solid tumors to find out how often their cancers have a specific genetic change called an NTRK fusion. Researchers used advanced DNA and RNA testing on tumor samples to identify these fusions. The goal was to understand how c…

This study examined how age, income, and other factors influence whether elderly cancer patients receive treatment and how long they live. Researchers analyzed data from 450 people aged 65 and older in a French region. The goal was to understand why some seniors get less care and…

This study brought together experts to decide what health outcomes matter most when testing cancer treatments in older adults. Instead of focusing only on tumor shrinkage, they identified key areas like independence, memory, mood, and nutrition. The goal is to help future clinica…

This study aimed to objectively measure erectile dysfunction in men three months after treatment for early-stage rectal cancer. Twelve sexually active men were monitored overnight using a device that records erections. The goal was to better understand a common but often undiscus…

This study looked at 54 women with breast cancer who had surgery under general anesthesia. Some had received a type of chemotherapy called anthracyclines, which can be hard on the heart. Researchers measured a heart stress marker called BNP before, during, and after surgery to se…

This study looked at 228 women with ductal carcinoma in situ (DCIS) or micro-invasive breast cancer who needed a mastectomy. The goal was to see if doing a sentinel lymph node biopsy before mastectomy could help some women avoid a more extensive lymph node removal later. The resu…