Glaxosmithkline

This study tests an experimental RSV vaccine in Chinese adults aged 18 to 59 who have health conditions that put them at higher risk for severe RSV disease. Researchers will check if the vaccine produces a strong immune response in this group compared to older adults (60+) who re…

This study tests a new vaccine designed to protect infants against two serious bacterial infections: invasive nontyphoidal salmonella (iNTS) and typhoid fever. Around 537 healthy infants in Africa will receive the vaccine at either 6 weeks or 6 months old. Researchers will monito…

This study tests a new chickenpox vaccine given as a muscle injection in healthy children aged 12 to 15 months. It compares the immune response and safety of this vaccine to the standard shot given under the skin. About 900 children will take part to see if the muscle shot works …

This study tests a new chickenpox vaccine in healthy children aged 12-15 months who have never had chickenpox or been vaccinated. The goal is to see if the new vaccine works as well as the current one. About 600 children will take part, receiving two doses three months apart.

This study tests a new vaccine designed to prevent urinary tract infections (UTIs) caused by E. coli bacteria. Researchers will first check safety and immune response in 448 adults aged 18-64, then measure how well it works in women of the same age. Participants receive either th…

This study is testing a malaria vaccine (RTS,S/AS01E) in 238 healthy children aged 5 months to 5 years living in an area where malaria is common. Researchers want to see if giving a lower dose or changing the vaccination schedule is still safe and helps the body build immunity. T…

This study is testing a shingles vaccine in children aged 1 to 17 who have had a kidney transplant and have a weakened immune system. The goal is to see if the vaccine is safe and helps their bodies fight off shingles. Researchers will give two doses of the vaccine and watch for …

This study looks at how well an RSV vaccine works and how safe it is in adults aged 18 and older who have had a lung or kidney transplant. Researchers will check if the immune response from a previous dose lasts and what happens when participants get another dose. The goal is to …

This early-stage study tests a new mRNA vaccine that aims to protect against both seasonal flu and COVID-19 with a single shot. About 225 healthy adults aged 65 to 85 will receive either the combo vaccine, a standard flu vaccine, or a COVID-19 vaccine. Researchers will monitor si…

This study tests whether a three-drug inhaler (FF/UMEC/VI) works better than a two-drug inhaler (FF/VI) for teens aged 12-17 with asthma that is not well controlled. About 292 participants will use the inhalers for 24 weeks, and doctors will measure lung function and symptom cont…

This early-stage trial tests a new drug, GSK5458514, designed to help the immune system attack prostate cancer cells. It is for men with metastatic castration-resistant prostate cancer (mCRPC), a type that has spread and stopped responding to hormone therapy. The study will first…

This early-stage study tests a new drug called GSK5764227, alone or with other cancer medicines, in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors…

This study tests an experimental oral drug (GSK5460025) in adults with advanced solid tumors that have specific genetic features (dMMR or MSI-H), which can make them harder to treat. The goal is to see if the drug can shrink tumors, how safe it is, and how the body processes it. …

This study compares a new drug, IDRX-42, to the standard drug sunitinib in adults with advanced gastrointestinal stromal tumors (GIST) that have spread or can't be removed by surgery and have already been treated with imatinib. The main goal is to see if IDRX-42 delays cancer gro…

This study tests a drug called belantamab, alone or with other treatments, for people with multiple myeloma (a type of blood cancer). It includes 152 adults whose cancer has come back or not responded to prior therapies. The goal is to find safe doses and see how well the drug co…

This study tests whether the drug belimumab can improve lung function and reduce skin thickening in adults with systemic sclerosis (scleroderma) that has caused lung scarring. About 300 participants will receive either belimumab or a placebo, added to their usual care. The main g…

This study tests an experimental drug called GSK4532990 in 393 adults with alcohol-related liver disease. The goal is to see if the drug can safely reduce liver stiffness and improve liver function over 52 weeks. Participants will receive either the drug or a placebo, and researc…

This study tests a new drug called mocertatug rezetecan (Mo-Rez) combined with other cancer medicines for people with advanced solid tumors that have stopped responding to standard treatments. About 305 adults will take part to see if the combination is safe, tolerable, and effec…

This study tests a new medicine called Ris-Rez that targets a protein on cancer cells to stop them from growing. It is for people with small cell lung cancer that has come back after initial treatment. About 420 adults will be randomly assigned to get either Ris-Rez or the standa…

This study tests a drug called depemokimab in 150 adults with severe asthma caused by a type of inflammation linked to high levels of certain white blood cells (eosinophils). The goal is to see if the drug can reduce mucus plugs and airway thickening in the lungs over 26 to 52 we…

This study tests whether combining two drugs, momelotinib and luspatercept, can help people with myelofibrosis who need regular blood transfusions go without transfusions for at least 12 weeks. About 68 adults with primary or secondary myelofibrosis, whether or not they have had …

This study tests whether adding the drug dostarlimab to standard chemotherapy (CAPEOX) works better than chemotherapy alone for a certain type of colon cancer. The treatment is given before surgery to shrink tumors. About 120 people with stage III or T4N0 colon cancer that has no…

This study tests a drug called dostarlimab combined with chemotherapy (carboplatin and paclitaxel) in 30 Chinese patients with advanced or recurrent endometrial cancer that has specific genetic markers (dMMR/MSI-H). The goal is to see if the treatment shrinks tumors and keeps the…

This study tests a drug called belimumab in 350 adults recently diagnosed with lupus (within 2 years). The goal is to see if it can reduce disease activity and help patients feel better over 3 years. Participants receive the drug as a weekly injection under the skin, alongside th…

This early-stage study tests a new drug called GSK5533524, alone or with other cancer treatments, in about 97 adults with advanced solid tumors that have stopped responding to standard therapies. The main goals are to find a safe dose and see if the drug can shrink tumors or slow…

This study tests a new medicine called depemokimab for people with moderate to severe COPD who have a type of inflammation called type 2. The goal is to see if adding this drug to standard treatment can reduce the number of serious flare-ups and improve breathing. About 1,200 par…

This early-stage study tests a new drug called GSK5733584 in adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety and find the right dose. About 675 people will take part, and researchers will also measure…

This study tests an investigational drug called depemokimab in adults with hypereosinophilic syndrome (HES) that is not well controlled by current treatments. About 123 participants will receive either depemokimab or a placebo added to their usual therapy for 52 weeks. The main g…

This early-stage study tests a new drug, GSK4527363, for safety and how the body processes it. It includes healthy adults, people with active lupus, and those with lung scarring linked to connective tissue disease. The goal is to find safe dosing and check for side effects before…

This study tests a new medicine called GSK5764227 in people with advanced gastrointestinal cancers that have spread and not responded to prior treatments. The goal is to see if the drug can shrink tumors and how safe it is. About 320 adults will take part worldwide.

This study offers ongoing access to the drug niraparib for people with ovarian or breast cancer who have already been taking it in a previous study and are still benefiting. The main goal is to monitor long-term safety and side effects. About 30 participants will continue treatme…

This study tests whether a new combination of drugs (belantamab mafodotin, lenalidomide, and dexamethasone, or BRd) works better than a standard combination (daratumumab, lenalidomide, and dexamethasone, or DRd) for people newly diagnosed with multiple myeloma who cannot have a s…

This study tests a new medicine called depemokimab for adults aged 40 to 80 with moderate to severe COPD and type 2 inflammation. The goal is to see if adding this drug to standard treatment can reduce the number of moderate or severe flare-ups that require steroids, antibiotics,…

This study tests whether giving the drug belantamab mafodotin less often, combined with other standard cancer medicines, can still control multiple myeloma while reducing side effects like eye problems. About 200 adults whose cancer has returned or stopped responding to prior tre…

This phase 3 trial tests whether the immunotherapy drug dostarlimab, given after standard chemoradiation, can help prevent head and neck cancer from coming back or spreading. About 864 adults with advanced, inoperable head and neck squamous cell carcinoma will receive either dost…

This study tests a new medicine, GSK5764227, that delivers a toxin directly to cancer cells to destroy them while leaving healthy cells alone. It is given together with standard treatments to people with advanced solid tumors, such as colorectal or prostate cancer. The main goals…

This study is the first time a new experimental malaria drug, GSK4024484, is being tested in humans. The main goal is to see if it is safe for healthy adults and how the body processes it. Researchers will also check if taking the pill with food changes its effects. The study inv…

This early-stage study is testing an experimental drug called GSK5926371 in people with autoimmune rheumatic diseases like lupus and rheumatoid arthritis. The drug works by helping the body's immune cells target and destroy certain immune cells that are causing the disease. The m…

This study tests an experimental drug called GSK5471713 in about 54 adults with a type of advanced prostate cancer that has spread and stopped responding to standard hormone treatments. The main goals are to check the drug's safety, find the right dose, and see if it can help con…

This study tests whether the immunotherapy drug dostarlimab, given before and after surgery, works better than standard treatments for people with a specific type of colon cancer (dMMR/MSI-H) that has not spread. About 892 participants will be randomly assigned to receive either …

This study tests a new medicine called efimosfermin alfa in people with MASH, a liver disease linked to metabolic issues. The goal is to see if the drug is safe and tolerable for patients with moderate liver scarring (stage F2 or F3). About 1,250 adults will receive either the dr…

This study tests a new medicine called efimosfermin alfa in 1,200 adults with MASH (a type of fatty liver disease) and moderate-to-severe liver scarring. The goal is to see if the drug can reduce scarring and resolve liver inflammation without making the disease worse. Participan…

This study tests an experimental drug called depemokimab in adults aged 40-80 with moderate to severe COPD and type 2 inflammation. The goal is to see if adding this medicine to standard care can reduce the number of moderate or severe flare-ups (exacerbations) that require stero…

This study looks at the long-term safety and effectiveness of belimumab in adults with lung scarring (interstitial lung disease) caused by scleroderma or other connective tissue diseases. About 514 people who finished a previous belimumab study will continue treatment for up to 3…

This study looks at how well the drug belimumab works in everyday medical practice for adults with active lupus nephritis, a kidney disease caused by lupus. Researchers will follow about 300 people for up to 5 years to see if their kidney function stays stable and if they avoid n…

This study tests a drug called momelotinib in 80 adults with low-risk myelodysplastic syndromes (MDS) who have anemia. The goal is to see if the drug can help them go without red blood cell transfusions for at least 12 weeks. The trial has two parts: first to find the best dose, …

This study tests if the drug belimumab can help adults with lung scarring (interstitial lung disease) caused by connective tissue diseases like rheumatoid arthritis or lupus. The goal is to see if it can stabilize or improve lung function and reduce symptoms like shortness of bre…

This study looks at the long-term safety and effects of the experimental drug GSK4527226 in people with early Alzheimer's disease. All 220 participants will receive the drug and must have completed a previous related study. The main focus is on side effects, including brain swell…

This study tests a new pneumococcal vaccine (PnMAPS30plus) in 120 healthy adults aged 50 to 64. Participants receive one dose of either the new vaccine or an approved one (PCV20) and are monitored for about six months. The goal is to check if the new vaccine is safe and helps the…

This large study in Finland is testing whether the Shingrix vaccine, which prevents shingles, can also reduce the risk of developing dementia in adults aged 76 and older. About 33,600 participants will receive either the vaccine or a placebo and be monitored for new dementia diag…

This study looks at whether a new propellant (HFA-152a) in salbutamol inhalers works as well as the current one (HFA-134a) for people with mild asthma. About 84 adults aged 18 to 65 will take single doses of the inhaler and have their lung function measured. The goal is to make s…

This study is not testing a new treatment. Instead, it gathers up to 10 years of medical records and a one-time questionnaire from 3,500 people with asthma or COPD who were in an earlier study. The goal is to learn more about how these lung diseases progress and respond to treatm…

This study looks at new methods to predict whether immunotherapy drugs (dostarlimab and pembrolizumab) will work in people whose non-small cell lung cancer has returned. Researchers will use blood samples, lab-grown tumor models, and special PET scans to see if these tools can fo…

This study looks at how a single dose of the experimental drug efimosfermin alfa behaves in the body and how safe it is for people with different levels of liver damage caused by fatty liver disease. About 32 adults aged 18 to 70 with liver cirrhosis will take part. The goal is t…

This early-stage study tests a single dose of efimosfermin alfa in 30 healthy adults of Chinese, Japanese, and White/European ancestry. The goal is to check safety, how the drug moves through the body, and immune response. No direct treatment benefit is expected; results will gui…

This study looks at how the body processes a single dose of bepirovirsen, a drug for hepatitis B, in people with different levels of kidney function. About 32 adults with either severe or moderate kidney disease, or healthy kidneys, will take part. The goal is to see if kidney pr…