Glaxosmithkline

This study tested an experimental RSV vaccine in adults aged 18-49 who are at increased risk for RSV disease, comparing their immune response and safety to adults aged 60 and older. Around 1,459 participants received the vaccine. The goal was to see if the vaccine works as well i…

This study tested a new vaccine designed to prevent diarrhea caused by Shigella bacteria, a major cause of illness in young children in Africa. The vaccine was first given to adults in Europe, then to adults, children, and infants in Africa to check safety and immune response. Re…

This study checked the safety and immune response of a meningitis B vaccine (Bexsero) when given alongside a pneumonia vaccine and other routine infant vaccines. About 1,200 healthy babies aged 6 to 12 weeks took part. Researchers monitored side effects and measured antibody leve…

This study tested an experimental RSV vaccine from GSK in over 2,600 adults aged 60 and older, mostly in China and some overseas. The goal was to see if the vaccine produces a strong immune response and is safe. Researchers compared immune responses between Chinese and overseas p…

This study tested a single shot of an experimental RSV vaccine in 751 adults aged 50 and older in India, including those at higher risk for severe RSV. The goal was to see how well the vaccine boosts the immune system and whether it is safe. Results help determine if the vaccine …

This study tested a new vaccine against cytomegalovirus (CMV) in 339 healthy adults aged 18 to 50. The vaccine uses lab-made proteins to train the immune system to fight CMV. The main goal was to check safety and how well the body responds to the vaccine, with different dose leve…

This early-stage study tested a new mRNA vaccine that aims to protect against both the flu and COVID-19 in a single shot. Researchers gave the vaccine to 106 healthy adults aged 18-64 to check for side effects and measure immune responses. The goal is to see if combining these va…

This study looked at whether giving an RSV vaccine and a COVID-19 booster at the same time works as well as giving them separately. About 841 adults aged 50 and older took part. The goal was to see if the combination is safe and produces a strong immune response against both viru…

This early-stage study tested a new mRNA-based flu vaccine in 324 healthy younger and older adults. The main goal was to see if the vaccine is safe and to measure the immune response it triggers. Researchers monitored side effects like pain, fever, and fatigue, and checked antibo…

This study tested new COVID-19 mRNA booster vaccines in 692 healthy adults who had already received their primary vaccination series. The goal was to see how well the boosters boosted immunity and if they were safe. Participants received either an investigational booster or a con…

This study looked at whether giving the polio vaccine at the same time as a rotavirus vaccine is safe and works well in healthy Chinese infants aged 6 to 10 weeks. About 400 babies took part. The goal was to see if the immune response to the polio vaccine was strong enough and if…

This early-stage study tested a new hepatitis B vaccine that includes an experimental booster called AS37. The goal was to see if the vaccine is safe and triggers a strong immune response. 122 healthy adults aged 18-45 received two doses, and researchers monitored side effects an…

This study tested an experimental mRNA vaccine designed to protect against a potential pandemic caused by the H5 bird flu virus. Nearly 1,000 healthy adults aged 18 to 85 received the vaccine to check for side effects and measure immune responses. The goal was to find the best do…

This study tested a new vaccine designed to protect against two serious bacterial infections: typhoid fever and invasive nontyphoidal salmonella (iNTS). The vaccine was given to 155 healthy adults, first in Europe and then in Africa, to check for side effects and measure immune r…

This study tested a new mRNA-based flu vaccine in 845 healthy adults aged 18 to 85. The goal was to find the best dose and check how well it triggers an immune response and how safe it is. The vaccine uses mRNA technology, similar to some COVID-19 vaccines, to teach the body to f…

This study tested a shingles vaccine (HZ/su) in 1,430 adults aged 50 and older who had already had shingles. Participants received two shots two months apart or a placebo. The goal was to see if the vaccine could prevent shingles from coming back and to check its safety. The stud…

This study tested an experimental RSV vaccine in adults who had lung or kidney transplants, as well as in healthy older adults. Researchers wanted to see if one or two doses of the vaccine could safely boost the immune system's ability to fight RSV, a common and potentially serio…

This study looked at how well a booster dose of the meningitis B vaccine works in healthy people aged 10 to 20 who got the vaccine as babies. Researchers compared their immune response to those who never had the vaccine. The goal was to see if the booster provides strong protecti…

This study followed over 7,500 older adults who received the shingles vaccine to see how well it prevents shingles over many years. Researchers also tested giving one or two extra vaccine doses to see if they boost protection. The vaccine was found to be effective and safe during…

This study tested the RTS,S/AS01E malaria vaccine in over 77,000 young children across sub-Saharan Africa. Researchers checked the vaccine's safety and how well it prevents malaria as part of routine childhood shots. The goal is to protect children from this serious disease.

This study tested a new two-step treatment for adults with chronic hepatitis B who are already on standard antiviral pills. First, participants received an experimental drug (ASO) for 12 or 24 weeks, followed by a targeted immunotherapy. The goal was to see if this sequence could…

This study tested new combinations of tuberculosis (TB) drugs in 127 adults with drug-sensitive TB. Participants received one of several two-drug combinations or standard care for 14 days, then switched to standard treatment. The goal was to see how quickly the drugs killed TB ba…

This study tested different doses and schedules of the drug belantamab mafodotin in 177 adults with multiple myeloma that had returned or not responded to at least three prior treatments. The goal was to see if changing the dose could reduce serious eye problems while still contr…

This study tested a new drug called depemokimab in 276 adults with chronic sinusitis and nasal polyps. The goal was to see if the drug could shrink polyps and ease nasal blockage over 52 weeks. Participants received either the drug or a placebo, and doctors measured changes using…

This study compared a new drug called depemokimab (GSK3511294) to two existing treatments (mepolizumab and benralizumab) in over 1,700 people aged 12 and older with severe eosinophilic asthma. The goal was to see if switching to depemokimab is as effective at preventing asthma at…

This study looked at how well the triple-combination inhaler Trelegy Ellipta works for people with chronic obstructive pulmonary disease (COPD) in real-world settings. Over 12 weeks, 463 adults aged 40 and older with moderate-to-severe symptoms used the inhaler once daily. Resear…

This study looked at how a lupus medicine called belimumab works in Chinese children aged 5 to 17 who had already been treated with the IV form for 48 weeks. The goal was to see how the drug moves through the body and if it is safe when given as a shot under the skin. Sixteen chi…

This early-stage study tested a new oral antibiotic, GSK3882347, in 140 women with uncomplicated urinary tract infections (UTIs). The goal was to see if the drug could safely clear the infection compared to a standard antibiotic. Results help determine if further testing is warra…

This study tested a new medicine called bepirovirsen in 981 adults with chronic hepatitis B who were already on standard antiviral therapy. The goal was to see if bepirovirsen could suppress the virus enough to allow patients to stop all hepatitis B treatments and stay virus-free…

This study tested a single dose of an experimental drug called GSK4532990 in 61 adults with non-alcoholic fatty liver disease (NASH). The goal was to see how the drug moves through the body, how it affects the liver, and whether it is safe. Participants were followed for about 24…

This study followed over 3,000 adults with active lupus for up to 5 years to see how safe and effective Benlysta (belimumab) is when added to standard treatment. Researchers tracked serious side effects like infections, cancer, and psychiatric events. The goal was to understand r…

This study tested a monthly injection called depemokimab in 264 adults with chronic sinusitis and nasal polyps. The goal was to see if it could shrink polyps and improve nasal blockage over 52 weeks. Participants had moderate to severe polyps and had tried other treatments like s…

This study looked at the long-term safety of a drug called depemokimab in 641 adults and teenagers with severe asthma that involves high levels of certain white blood cells (eosinophils). Participants had already completed earlier studies of the drug and continued treatment for 1…

This study tested a new drug, belantamab mafodotin, in 221 adults with multiple myeloma that had not responded to at least three prior treatments. The drug is an antibody-drug conjugate that delivers a toxin directly to cancer cells. The goal was to see if it could shrink tumors …

This study tested an experimental immunotherapy for the herpes simplex virus (HSV) in 505 people. Part 1 looked at safety in healthy adults aged 18-40, while Part 2 tested two versions of the shot in people aged 18-60 with recurrent genital herpes. The goal was to see if the trea…

This study looked at how safe and effective Benlysta is for people with lupus when used in normal medical practice. Over 1,500 patients were followed for one year. Researchers tracked side effects, disease activity, and quality of life to ensure the drug works well outside of con…

This study tested whether adding the drug niraparib to the immunotherapy pembrolizumab helps keep advanced non-small cell lung cancer from growing after initial chemotherapy. About 666 adults with stage IIIB/IV lung cancer whose disease was stable or improved after first-line tre…

This study looked at the long-term safety and effectiveness of the drug NUCALA in people with a rare disease called EGPA, which causes inflammation in blood vessels. About 300 adults who were already prescribed NUCALA for EGPA were followed for up to 2 years. Researchers tracked …

This study tested a drug called daprodustat in children aged 3 months to under 18 years who have anemia due to chronic kidney disease. The goal was to see how the drug moves through the body and if it is safe. The study included children both on and off dialysis and lasted about …

This study tested a drug called mepolizumab in 16 children aged 6 to 17 with hypereosinophilic syndrome (HES), a rare condition where too many white blood cells cause damage. The goal was to see if the drug could reduce disease flares and the need for steroids. Over 52 weeks, mos…

This study looked at whether adding belimumab to standard treatment is safe and works for Chinese children (ages 5-17) with active lupus. Over 52 weeks, researchers tracked side effects and disease activity using a standard lupus score. The goal was to see if the drug combination…

This study tested a drug called belimumab in children aged 5 to 17 with active lupus. The goal was to see if adding belimumab to their usual treatment could better control the disease. The trial measured how many kids had less lupus activity after one year. Belimumab is not a cur…

This study tested a new vaccine called AFX3772 in healthy infants about 2 months old to see if it can safely prevent pneumococcal disease, which causes pneumonia and other serious infections. Researchers compared three different doses of AFX3772 with two existing vaccines (Prevna…

This study tested a new vaccine called altSonflex1-2-3 to prevent shigellosis, a severe type of diarrhea, in 200 healthy African infants. The vaccine was given in two doses to see if it triggers a strong immune response and is safe. The goal is to find a simpler vaccination sched…

This study tested an oral antibiotic called gepotidacin in 97 adolescent and adult women with uncomplicated urinary tract infections (UTIs). The goal was to see if it could quickly improve symptoms like pain and urgency within 24 hours. Results showed that most participants exper…

This study looked at the long-term safety of a new propellant (HFA-152a) used in salbutamol rescue inhalers for adults with asthma. It compared the new propellant to the current standard (HFA-134a) in 477 participants. The main goal was to see if the new propellant caused any sid…

This study followed women who had received an RSV vaccine or a placebo in previous studies to see if it affected their later pregnancies. No new vaccine or treatment was given. The goal was to monitor pregnancy outcomes and safety in both mothers and babies. About 3,855 participa…

This study looked at 193 people with lupus nephritis (kidney inflammation caused by lupus) across five Gulf countries. Researchers collected information on patient backgrounds, treatments, and quality of life to better understand the disease and its long-term effects. The goal wa…

This study tested whether a new propellant (HFA-152a) used in inhalers affects the lungs' ability to clear mucus, compared to a standard propellant (HFA-134a). Twenty-four healthy adults inhaled each propellant and then breathed in a harmless radioactive tracer to measure lung cl…

This study tested a new propellant (HFA-152a) in salbutamol inhalers to see if it delivers the drug similarly to the current propellant (HFA-134a). Sixty healthy adults aged 18-55 received single doses of 200 or 800 micrograms in a crossover design. The goal was to compare how mu…