Columbia University

This study tests whether a home blood pressure monitoring program helps people with high blood pressure get it under control. About 24,000 adults from primary care clinics will use home monitors and receive support. The goal is to see if this approach lowers blood pressure over 1…

This study tests a web-based program called CAMP Air designed to help urban teens with uncontrolled asthma. About 374 Black and Hispanic adolescents will use the program to improve symptom control and reduce emergency visits. The goal is to see if an online approach can make asth…

This study looks at the best way to provide HIV prevention medicine (PrEP) and hepatitis C treatment to people who inject drugs. About 446 participants will either get all their care at one location or be referred to a specialist elsewhere. The goal is to see which approach leads…

This study looks at whether adding heart-healthy education and culturally relevant recipes to medically tailored meal programs helps people with type 2 diabetes and high blood pressure eat better and improve their blood sugar and blood pressure. About 176 adults from low-income N…

This study tests a program where doulas provide mental health coaching and heart health education to new mothers after childbirth. The goal is to reduce postpartum depression and improve heart health. About 450 Black, Latinx, or Medicaid-covered mothers will take part, starting i…

This study tests a daily pill called axitinib in adults with rare adrenal gland tumors (pheochromocytoma or paraganglioma) that have spread or cannot be removed. The main goal is to see how many patients' tumors shrink or disappear. Researchers also track how long the disease sta…

This study tests a treatment for a rare and aggressive adrenal cancer that has spread to the lining of the abdomen. About 30 people will have surgery to remove all visible tumors, followed by heated chemotherapy (HIPEC) delivered directly into the abdomen. The goal is to see if t…

This study tests if a gentle red light treatment, called photobiomodulation, can help embryos grow better during IVF. As women age, the energy centers in their cells may not work as well, making it harder for embryos to develop. The study will include 200 women aged 18 to 48 usin…

This early-phase study tests whether an FDA-approved drug called glycerol phenylbutyrate (PBA) can improve vision in people with a rare inherited form of color blindness caused by ATF6 gene mutations. Only 2 adults with confirmed ATF6 mutations and reduced retinal function are be…

This study tests whether taking nicotinamide and pyruvate (N&P) supplements can help preserve vision in people with open-angle glaucoma. About 250 adults aged 35–85 will take either N&P or a placebo for 20 months, while continuing their standard glaucoma eye drops. The goal is to…

This study tests two natural substances (deoxythymidine and deoxycytidine) as a treatment for TK2 deficiency, a rare genetic disorder that causes severe muscle weakness and breathing problems. The treatment is designed to help cells make more mitochondrial DNA, which may reduce s…

This study tests a behavioral therapy designed to reduce violent behavior in young adults (ages 16-30) who are in the early stages of psychosis, including schizophrenia. The therapy is given alongside their usual care. The main goals are to see if the therapy is acceptable and fe…

This study tests whether a special team that treats both severe infections and substance use disorders together can help hospitalized patients who inject drugs. The goal is to lower death rates and prevent repeat hospital visits. About 480 adults will either get this integrated c…

This study tests whether adding special sugars found in breast milk (called human milk oligosaccharides) to the diet of HIV-exposed but uninfected infants can reduce infections and improve growth. About 140 babies will receive either the supplement or a placebo from 4 to 24 weeks…

This early-phase study tests a new treatment called NKX019 for people with lupus, an autoimmune disease. NKX019 uses specially engineered immune cells to target and calm overactive B cells. The main goal is to check safety in 6 adults, while also seeing if it reduces lupus sympto…

This study tests whether a low dose of rapamycin, a drug that affects aging pathways, can slow down ovarian aging in women aged 35 to 45 who are in early menopause transition. Researchers will measure hormone levels and egg supply over time. The goal is to see if the drug can ext…

This study tests whether doing extra MRI scans each week during radiation treatment can help doctors adjust the radiation plan to better target high-grade gliomas, a type of aggressive brain tumor. About 20 adults with newly diagnosed tumors will receive standard radiation plus w…

This study tests whether a year of romosozumab followed by a year of denosumab can safely increase bone density in 30 premenopausal women aged 18-48 with idiopathic osteoporosis. Participants receive monthly injections of romosozumab for 12 months, then denosumab every 6 months f…

This study looks at whether a new, non-invasive ultrasound imaging method called electromechanical wave imaging (EWI) can more accurately diagnose the location and cause of heart rhythm problems (arrhythmias) than standard tests. About 322 adults already scheduled for a heart pro…

This study aims to create and test a tool that uses chest CT scans to help doctors more accurately diagnose different types of pulmonary fibrosis, a condition where lung tissue becomes scarred. Researchers will analyze CT scans from 400 adults to identify patterns linked to speci…

This study tests whether text messages or automated phone reminders help parents get their daughters (ages 10-14) the HPV vaccine on time. About 396 parents in Kampala, Uganda, will be enrolled. The goal is to see if simple reminders improve how many girls start and finish the tw…

This study tests whether metformin, a common diabetes medication, can prevent Alzheimer's dementia in people with mild cognitive impairment. About 326 overweight adults aged 55-90 without diabetes will take either metformin or a placebo for 18 months. Researchers will track memor…

This study tests a program that connects caregivers of adolescent and young adult cancer survivors with community resources to address unmet financial and social needs. About 60 caregiver-patient pairs will participate. The goal is to see if this navigation support is helpful and…

This study tests whether rituximab or tocilizumab can help people with advanced cancer stop taking steroids for side effects caused by immunotherapy. The trial enrolled 8 participants who had steroid-dependent immune-related side effects. The goal is to see if these drugs can con…

This study tests whether transferring a person's own fat to the wrist can ease carpal tunnel syndrome better than standard steroid shots. The idea is that fat may help nerves heal and glide more smoothly. The study was planned for 100 adults with mild to moderate symptoms but is …

This study looks at whether taking a short course of oral methylprednisolone (a steroid) after knee replacement surgery can help reduce pain, the need for strong painkillers, and nausea. About 116 adults with knee osteoarthritis who are having a first-time knee replacement will t…

This study looks at how diet and body composition (muscle vs. fat) change in Indian children undergoing treatment for acute lymphoblastic leukemia. Researchers will measure muscle loss and fat gain using a special body scan. The goal is to understand how these changes affect trea…

This study looks at how certain genes influence brain inflammation in people with Alzheimer's disease. Researchers will use a special PET scan to measure immune cell activity in the brain. The goal is to find new genetic markers that affect this process, which could lead to bette…

This study looks at whether getting a medication abortion through telemedicine (video or phone visits) leads to different results than getting it in person. Researchers will track how many people need extra doctor visits after the procedure. The goal is to understand patient expe…

This study looks at how social factors like poverty and access to care affect the risk of maternal sepsis—a leading cause of death in new mothers. Researchers will interview 200 patients and community stakeholders in New York hospitals to gather their experiences and ideas. The g…

This study looks at whether teens and young adults with Polycystic Ovary Syndrome (PCOS) have more fat in their liver than those without PCOS. Researchers will use advanced scans and tests to measure liver fat, insulin resistance, and cholesterol in 80 participants aged 14-25. Th…

This study aims to find the genetic causes of mitochondrial disorders—diseases that affect how cells produce energy. Researchers will analyze tissue samples from up to 6900 people who have or are suspected of having a mitochondrial disorder, such as MELAS or Leigh disease. The go…

This study follows 1,520 mostly Black and Latinx adults who had COVID-19 to understand long-term health problems. Participants complete surveys and some give blood and nasal swabs up to 12 months after infection. The goal is to learn how infection severity affects recovery and im…

This study follows 286 adults with Alpha-1 Antitrypsin Deficiency, a genetic condition that can damage the lungs and liver. Researchers use CT scans and blood tests to track how lung density changes over three years. The goal is to find better ways to measure disease progression,…

This study looks at how the health of blood vessels and genetics may be linked to early signs of COPD and emphysema. Over 4,300 adults from a larger heart study took part. Researchers measured lung function and used CT scans to check for lung damage, aiming to understand the role…

This study offers free vision screenings to underserved adults over 40 living in affordable housing in Harlem and Washington Heights. The goal is to find eye problems like glaucoma, cataracts, and diabetic retinopathy early and connect people with follow-up care. About 749 partic…

This study looks at two different ways of setting a breathing machine (ventilator) for people with sepsis who need help breathing. The researchers use CT scans to see how air moves in the lungs and compare a personalized setting to a standard one. The goal is to find out which me…

This study looks at whether fixing a blocked carotid artery (a major blood vessel in the neck) can reverse thinking and memory problems in people who have no stroke symptoms. About 385 participants from a larger trial will have brain scans and thinking tests over one year. The go…

This study looks at a rare form of retinitis pigmentosa caused by changes in the CNGB1 gene. Researchers want to understand how vision loss progresses over 3 years in 20 people. The goal is to find the best tests to measure the disease, so they can use them in a future gene thera…

This study was designed to test a smartphone app called iBlink that measures a simple form of learning (eyeblink conditioning) in people with spinocerebellar ataxias, a group of rare brain disorders that affect movement. The goal was to see if aerobic exercise improves this learn…

This study was designed to test if a technique called self-distancing—where children use 'you' or their own name instead of 'I' when talking to themselves—helps them approach scary things, like spiders, during therapy. It planned to enroll children aged 7 to 12 with spider phobia…

This study looks at heart failure patients with a severe leaky tricuspid valve who received a new valve through a tube in a blood vessel (transcatheter replacement). It focuses on those who had unstable blood pressure right after the procedure. Researchers want to understand how …

This study is testing a safety planning intervention designed for children ages 6-12 who have had suicidal thoughts or behaviors in the past month. Researchers want to see if the plan is clear and helpful to children and their caregivers, and whether it can reduce suicidal behavi…

This study looks at the health records of 400,000 birthing people to find better ways to predict and prevent maternal sepsis, a leading cause of death during and after childbirth. It focuses on understanding how social factors like poverty and race affect risk, especially for Bla…

This study looks at how working at night changes what and how much people eat compared to day workers. Researchers will measure hunger, fullness, and appetite hormones in 100 healthy adults in New York City. The goal is to find out why night workers are more likely to become obes…

This study tests a simple decision aid called Lock and Protect in the emergency department. It helps parents of teens who came in for suicidal thoughts or self-harm to safely store medications and firearms at home. The goal is to see if the tool is acceptable and feasible, and if…

This study aims to find the most effective way to invite people with uncontrolled high blood pressure to a medication adherence counseling session. Researchers will test different recruitment letters and phone call strategies with 584 adults from under-resourced communities. The …