Columbia University

This study looks at two ways to repair a torn ACL using a patient's own tendon. One group gets standard surgery, the other gets an extra internal brace for extra support. Researchers will track how quickly 200 people return to sports and how stable their knees stay over 10 years.

This study tests if a newer blood thinner called apixaban works better and causes fewer side effects than the standard drug warfarin in people with advanced heart failure who have a HeartMate 3 heart pump. About 460 adults who have had the pump for at least 3 months will be rando…

This study compares two common treatments for a first-time shoulder dislocation: surgery (arthroscopic Bankart repair) versus physical therapy. Researchers want to find out which approach leads to better long-term shoulder stability and quality of life. The trial will enroll 200 …

This early-stage study tests whether focused ultrasound can safely open the blood-brain barrier in 6 people with early Alzheimer's. The goal is to see if this temporary opening helps clear harmful amyloid and tau proteins from the brain. Researchers will also check for side effec…

This study will place cost-effective HEPA air cleaners in the homes of 55 children (ages 7-18) with asthma living in low-income housing in East Harlem, NYC. Researchers will measure indoor air pollution and track asthma symptoms, lung function, and emergency visits over a year. T…

This study compares surgery (MPFL reconstruction) to a structured rehab program for people who have dislocated their kneecap for the first time. The goal is to see which approach better prevents future dislocations and improves knee function. About 200 participants aged 12 and ol…

This study looks at how a device called Barostim affects heart function and symptoms in adults with heart failure and reduced pumping ability. About 58 people will get the device implanted and adjusted. The goal is to see if it improves blood flow and exercise capacity.

This early-stage study tests the safety of a drug called EMPAVELI in 20 adults who had a stroke from a large blood clot and already had it removed. The drug is given through a pump shortly after the procedure and again at 24 and 48 hours to reduce swelling and inflammation when b…

This study will compare three tests that check if a tooth's nerve is still alive: laser Doppler flowmetry, electric pulp testing, and cold testing. About 150 people who need root canal treatment will take part. The goal is to see which test is most accurate at telling if a tooth …

This study compares ketamine to morphine for treating sudden, severe pain in children visiting the emergency department. About 1,010 children with belly pain or a broken arm or leg will receive one of the two medicines. The goal is to see if ketamine works just as well as morphin…

This study tests adding dexmedetomidine or clonidine to standard spinal anesthesia for C-sections. The goal is to reduce uncomfortable pulling or pressure sensations during surgery and improve pain relief afterward. About 150 pregnant women having a C-section will take part.

This study will test whether a culturally-based live music intervention can lower stress and reduce the risk of preterm birth in pregnant Black women. Researchers will compare the music group to a control group that only receives verbal support. The goal is to see if music can im…

This study tests whether giving children (ages 5-17) a breathing machine called BPAP early in the emergency room can help them recover faster from severe asthma attacks. About 36 kids will either get standard asthma care alone or standard care plus BPAP. The goal is to see if thi…

This study looks at whether using an EEG (a brain-wave monitor) during surgery to guide pain medication can lower the risk of delirium—sudden confusion—after the operation. Researchers will enroll 600 adults aged 60 and older who are having non-emergency surgery. The goal is to s…

This study looks at how tirzepatide, a diabetes and weight-loss drug, helps people with obesity and a type of heart failure called HFpEF. Researchers will measure blood volume and body fat in 50 patients over 15 months to understand why the drug improves symptoms. The goal is to …

This study looks at how changing insulin levels affects the liver's production of sugar and fat in people with insulin resistance and fatty liver disease. About 36 adults with overweight or obesity will undergo two procedures where insulin is either kept high or lowered by half. …

This study aims to improve how researchers measure muscle responses to electrical or magnetic stimulation. The new method uses a smart computer model to quickly find the best stimulation levels, reducing the number of tests needed. Ten healthy adults will participate, and the goa…

This study tests whether messages created by sex trafficking survivors can increase HIV/STI/HCV testing and use of overdose prevention kits. About 368 survivors in New York City will be randomly assigned to receive either survivor-created messages or standard public health messag…

This study will screen over 7,000 adults aged 40 and older living in affordable housing in New York City for undiagnosed or uncontrolled high blood pressure and glaucoma. Participants will receive free screenings and be referred to follow-up care. The goal is to see if a virtual …