Columbia University

This study tests whether a patch made from donated placental tissue can help rotator cuff tears heal better after surgery. Half of the 120 participants will get the patch along with standard repair, and the other half will get standard repair alone. An MRI one year later will che…

This study compares two blood thinners—apixaban (Eliquis) and warfarin (Coumadin)—in 460 people with advanced heart failure who have a HeartMate 3 heart pump. The goal is to see which drug better prevents strokes, pump clots, and serious bleeding. Participants must have had their…

This trial tests whether giving fluids more quickly than usual can safely correct severe hypernatremia, a dangerous condition where sodium levels in the blood are too high. Researchers will compare rapid rehydration against standard care in 80 adults with sodium levels of 155 mEq…

This pilot study tests whether ursodeoxycholic acid (UDCA), a medication already used for liver and gallbladder conditions, can improve healing of the esophagus after endoscopic treatment for Barrett's esophagus with dysplasia. The study follows about 15 patients who take UDCA du…

This early-stage study tests whether a focused ultrasound can safely and temporarily open the brain's protective barrier in people with early Alzheimer's disease. The goal is to see if this helps clear harmful amyloid and tau proteins that build up in the brain. Six participants …

This early-stage study tests the safety of a drug called pegcetacoplan (Empaveli) in 20 adults who have had a stroke from a large clot and already had a procedure to remove it. The drug aims to reduce swelling and inflammation that can occur when blood flow returns. Participants …

This study tests a community-based screening strategy for tuberculosis (TB) in migrant communities in New York City. A mobile van offers digital chest X-rays with AI interpretation, along with TB symptom checks, blood tests for latent TB, and HIV testing. The goal is to see wheth…

This study will compare three methods for testing whether a tooth's nerve is alive (vital) or dead (nonvital): laser Doppler flowmetry, cold testing, and electric pulp testing. About 150 people who need root canal treatment will receive all three tests before treatment. The goal …

This study will test whether a culturally-based live music intervention can reduce stress and lower the risk of preterm birth in pregnant Black women. 142 women in their first trimester will be randomly assigned to either music sessions or a verbal support group. Researchers will…

This early-phase trial tests a new nasal ointment called TOR-582, which contains sirolimus, in 27 adults with hereditary hemorrhagic telangiectasia (HHT) who have frequent nosebleeds. Participants apply the ointment inside their nostrils twice daily for 12 weeks, with different s…

This pilot study will test whether a 'Comfort Tote' filled with items like aromatherapy oils, stress balls, acupressure guides, and a journal can help teens aged 10-21 feel less pain, anxiety, and stress after scoliosis surgery. Half the participants will get a tote with therapeu…

This study looks at people with migraines who also have a small hole in the heart (PFO). Participants first take a blood-thinning drug (prasugrel) to see if their migraines improve. Those who respond are randomly assigned to either continue the drug alone or have a procedure to c…

This study compares ketamine to morphine for treating acute pain in children visiting the emergency department. Over 1,000 children with abdominal pain or broken bones will receive either drug. The goal is to see if ketamine works as well as morphine but with fewer side effects.

This study will test whether taking prednisone for 5 days after knee or hip replacement surgery helps reduce pain, swelling, and the need for opioids compared to the standard steroid given only during surgery. About 104 adults will participate, and their blood sugar will be track…

This study will test whether adding dexmedetomidine or clonidine to standard spinal anesthesia can reduce uncomfortable pulling, tugging, and pressure sensations during cesarean delivery. About 150 pregnant women having a C-section will be randomly assigned to receive one of the …

This study will test whether using EEG brain monitoring to adjust pain medicine during surgery can reduce the risk of delirium (sudden confusion) after surgery in adults aged 60 and older. Researchers plan to enroll 600 participants undergoing non-cardiac, non-head/neck surgery l…

Severe brain injuries can leave people in a coma or with limited awareness, and doctors struggle to predict who will recover. This study tests whether brain activity during sleep, measured with EEG, can forecast how quickly a patient wakes and how well they recover over a year. R…

This study will screen over 7,000 adults aged 40+ living in affordable housing in New York City for undiagnosed high blood pressure and glaucoma. Participants who need follow-up care will be randomly assigned to receive text message reminders or usual care. The goal is to see if …

This study looks at how lowering insulin levels changes the way the liver makes sugar and fat. Researchers will give 36 overweight or obese adults with insulin resistance and fatty liver disease two different insulin infusions—one that keeps insulin high and one that lowers it by…

This study tests whether digital messages created by sex trafficking survivors can encourage more HIV, STI, and hepatitis C testing, as well as use of overdose prevention kits. About 368 survivors in New York City will be randomly assigned to see either survivor-made messages or …