Chinese Pla General Hospital

This study focuses on older adults (over 60) with serious fungal infections like invasive aspergillosis. Researchers want to see if adjusting the dose of the antifungal drug isavuconazole based on individual patient factors can improve treatment outcomes and reduce side effects. …

This study tests a combination of two drugs (tunlametinib and an anti-EGFR antibody) in people with advanced colorectal or pancreatic cancer that has a RAS gene mutation and has not responded to standard treatments. The goal is to see if the combo can shrink tumors or slow cancer…

This early-phase trial tests whether a traditional Chinese herbal formula combined with bacteriophages (viruses that kill bacteria) can clear drug-resistant bacteria in 240 adults with severe pneumonia. The goal is to improve recovery and lower death rates. Participants must have…

This study tests whether real-time carbon dioxide monitoring (capnography) can prevent dangerously low oxygen levels during painless gastrointestinal endoscopy. About 460 patients will be monitored with this device, which gives early warning of breathing problems. The goal is to …

This early-stage study tests whether a non-invasive ultrasound technique can safely reduce seizures in people with epilepsy that doesn't respond to medication. Twenty adults will receive a targeted brain ablation using MRI-guided focused ultrasound and be monitored for two years.…

This study tests a treatment using bacteriophages—viruses that kill bacteria—for ventilator-associated pneumonia caused by hard-to-treat germs. About 248 adults on ventilators will receive the phage cocktail to see if it improves recovery and clears the infection. The goal is to …

This early-phase study tests a new treatment for people with advanced colorectal cancer that has spread to the liver and hasn't responded to at least two prior treatments. The treatment combines a modified virus (PIN) that kills cancer cells with an immunotherapy drug (sintilimab…

This early study tests a new treatment called KSVCBD, a type of CAR-T cell therapy, for people with a rare autoimmune disease called neuromyelitis optica spectrum disorder (NMOSD) that has not responded well to standard treatments. The goal is to see if the therapy is safe and if…

This study tests a new treatment plan for people with a certain type of advanced rectal cancer. The approach combines a short course of radiation with chemotherapy, targeted therapy, and immunotherapy before any surgery. The goal is to see if this combination can make the tumor d…

This study tests a special ultrasound technique to find tiny metal pieces left in the brain after aneurysm clipping surgery. About 78 adults will get this ultrasound within 3 hours after their operation, and results will be compared with standard CT scans. The goal is to see if t…

This study tests whether a mild electrical pulse to a nerve in the ear, given during heart surgery, can lower the chances of postoperative delirium (sudden confusion) and reduce anxiety or depression after the operation. About 270 adults having planned heart surgery will be rando…

This study looks at whether a single spray of numbing medicine inside the chest can reduce pain caused by drainage tubes after lung surgery. About 300 adults having lung surgery will be randomly assigned to receive one of two numbing sprays or a placebo spray. Pain levels and sle…

This study tests whether a new drug called NB001 can quickly stop migraine pain and other bothersome symptoms. About 120 adults with migraines will receive either NB001 or a placebo. The main goal is to see if more people are pain-free and symptom-free two hours after taking the …

This study looks at whether a daily pill called acemetacin can reduce pain and improve daily life for adults with active axial spondyloarthritis, a type of arthritis that mainly affects the spine. About 150 people aged 18 to 65 will take the medicine for 4 weeks. Researchers will…

This study looks at whether giving esketamine during breast cancer surgery can help reduce severe depression and anxiety in patients. About 242 women with severe depression will be randomly assigned to receive esketamine or a placebo during their operation. Researchers will measu…

This study tests if a mild electrical pulse on the ear during breast cancer surgery can reduce anxiety, depression, and pain after the operation. About 232 women will receive either real or fake stimulation to see if it helps them feel better and recover faster. The goal is a sim…

This study looks at whether giving esketamine continuously during breast cancer surgery can help reduce anxiety and depression in patients who already have mild-to-severe depressive symptoms. About 142 women will take part, and their mood and sleep quality will be tracked before …

This study tests a new device called Medstrom that monitors pain, sedation, and muscle relaxation all in one during laparoscopic colon cancer surgery. It compares the device to standard separate monitors in 30 adults aged 18-65. The goal is to see if the single device works just …

This study tests whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression after the operation. About 218 adults having breast cancer removal will be randomly assigned to receive esketamine or a placebo during anesthesia. Re…

This large observational study will follow 100,000 elderly Chinese adults to see how conditions like diabetes, high blood pressure, and high cholesterol impact kidney disease and overall health. Participants will provide blood and urine samples and be tracked over time through cl…

This study follows 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to multiple chronic conditions such as diabetes, heart disease, and metabolic syndrome. Participants will have regular health checks, blood and urine te…

This study tests a personalized approach to dosing the antibiotic ceftobiprole in people aged 60 and older. Researchers will measure drug levels in the blood and use computer models to adjust each patient's dose, aiming to improve effectiveness and reduce side effects. The goal i…

This study will test a new type of CT scanner (photon counting CT) to see if it can better identify and measure different parts of artery plaques in people with heart disease. Researchers will follow 180 adults for up to several years to see if these detailed images can predict s…

This study looks at whether measuring how the brain uses sugar (glucose) before surgery can help predict if older adults with type 2 diabetes will become confused or delirious after their operation. Researchers will scan the brains of 154 people aged 65 and older before liver tum…

This study aims to improve how a powerful antibiotic (ceftazidime-avibactam) is dosed in patients aged 60 and older. By measuring drug levels in the blood and using computer modeling, researchers hope to create a personalized dosing plan that maximizes effectiveness while minimiz…

This study will follow 10,000 adults with obesity across 50 hospitals in China to see what treatments doctors actually use and how patients respond. Participants will get routine weight-loss care, and researchers will collect health data like weight, blood tests, and liver scans …