Centre Hospitalier Universitaire De Nice

This study aimed to find the best dose of a key anti-rejection drug for people who have received a kidney transplant. Researchers compared how two different versions of the drug (tacrolimus) were processed by the body in 45 adult patients during the critical first three months af…

This study tested if starting treatment very early in vitiligo could stop the condition from spreading and help the skin regain its color. It involved 51 adults with non-segmental vitiligo who received a standard combination of UV light therapy and low-dose oral steroids for 24 w…

This study tested whether a daily probiotic supplement could help control recurrent, painful mouth ulcers (canker sores). For 3 months, 40 adults with this condition took either the probiotic or a placebo pill. Researchers then followed them for another 3 months to see if it redu…

This study tested whether adding an oral medication called apremilast to standard UVB light therapy helps restore skin color (repigmentation) in people with widespread, non-segmental vitiligo. For 24 weeks, all 80 participants received UVB light therapy twice a week. Those who re…

This study tested whether a clot-dissolving treatment could save lives in patients with severe brain bleeds caused by a burst aneurysm. It involved 19 patients who had suffered this type of catastrophic bleeding into the brain's fluid spaces. Researchers aimed to see if directly …

This study tested if adding a high-dose cholesterol medication (atorvastatin) to standard UVB light therapy could better control active vitiligo. It involved 28 adults with active, spreading vitiligo patches. Participants were randomly assigned to receive either UVB therapy alone…

This study tested whether low-dose injections of a medication called IL-2 could help regrow hair in adults with severe alopecia areata, a condition causing patchy or total hair loss. It was a Phase 3 trial comparing the injections to a placebo (dummy treatment) in 44 participants…

This study tested if a new skin cream could work as well as the current best treatment for melasma, a condition that causes dark patches on the skin. The new cream replaces a key ingredient (hydroquinone) that can cause side effects with a potentially safer alternative (thiamidol…

This study tested whether adding avdoralimab, an experimental antibody drug, to standard steroid creams could better control bullous pemphigoid, a painful blistering skin condition that mainly affects older adults. Fifteen hospitalized patients with confirmed bullous pemphigoid p…

This study tested whether a topical gel called Picato could treat lentigo maligna, a pre-cancerous skin condition on the face that can turn into melanoma. It was for patients who were not eligible for or refused standard surgery. Researchers applied the gel for three days to see …

This study compared two methods of giving the antibiotic cloxacillin to treat serious bone and joint infections. It involved 12 patients with infections caused by a specific bacteria. Each patient tried both a continuous 24-hour drip and the standard method of several shorter inf…

This study tested if adding a special antioxidant pill called GLISODIN to standard UVB light therapy works better for treating vitiligo than light therapy with a placebo pill. It involved 50 adults with widespread, non-segmental vitiligo. Researchers measured changes in the size …

This study tested a less invasive procedure to treat spinal instability that can occur after back surgery. Doctors used CT imaging to guide the placement of screws through the spinal joints to stabilize the area, all while the patient was awake with local anesthesia. The goal was…

This study compared two imaging tests used to find physical causes of infertility in women. Researchers wanted to see if a special type of MRI scan could work as well as the standard X-ray test, but without exposing patients to radiation. The study involved 40 women undergoing st…

This study looked at whether using a specific blood test could help doctors make better decisions about hospitalizing pregnant women with signs of pre-eclampsia. Pre-eclampsia is a serious pregnancy complication, but diagnosing it and predicting its severity is difficult. The res…

This study aimed to find out if ultrasound could be a safer and cheaper alternative to CT scans for monitoring patients after a minimally invasive abdominal aortic aneurysm repair. Researchers followed 659 patients who had both types of scans to see which method was better at spo…

This study tested whether a special eye scan called OCT angiography could help predict how well a patient's vision might recover after surgery for a pituitary tumor. Researchers compared this new scan to standard vision tests like visual acuity and visual field exams. The goal wa…

This study tested a blood test designed to detect specific genetic changes in lung cancer cells. The goal was to see if this 'liquid biopsy' could reliably match patients to targeted therapies, avoiding the need for invasive tissue biopsies. Researchers enrolled 206 patients with…

This study tested whether a specific blood test could better predict which patients with an autoimmune kidney disease called membranous nephropathy are at highest risk for their kidneys getting worse. Researchers followed 52 patients to see if measuring certain antibodies using a…

This study tested a new, more convenient device for diagnosing sarcopenia, which is age-related muscle loss that leads to frailty. Researchers compared a simple, seated bioimpedance scanner against the standard bone density scan in 72 adults aged 60 and over. The goal was to see …

This study tested whether giving iodine supplements to healthy pregnant women in an area with mild iodine deficiency improves their children's brain development. Researchers followed 85 children whose mothers were randomly assigned to take either standard prenatal vitamins or vit…

This small study tested whether a medication called tranexamic acid could prevent dark skin spots (post-inflammatory hyperpigmentation) that sometimes form after skin is injured. Researchers used a controlled method to create tiny blisters on the skin of 10 healthy men prone to t…

This study tested if an injection of a drug called etanercept directly into a painful, swollen joint could work better than a standard steroid injection for people with rheumatoid arthritis. It involved 34 adults who had a painful flare-up in a joint like the knee or wrist. The g…

This study tested a gentler surgical method for removing an appendix, called Low-Impact Laparoscopy (LIL), against the standard method. It involved 50 adults with uncomplicated appendicitis to see if the gentler technique caused less pain after surgery and helped patients recover…

This study tested a specific breathing technique used by anesthesiologists during weight-loss surgery. The goal was to see if this technique could help patients breathe easier and need less oxygen after their operation. Researchers compared patients who received the technique to …

This study looked back at a procedure to help cancer patients with a blocked portal vein, a major blood vessel to the liver. The blockage can cause severe fluid buildup in the belly (ascites) or dangerous bleeding. Doctors placed a small mesh tube (stent) to prop the vein open. T…

This study tested whether using connected fitness devices could help people with spondyloarthritis stick to regular physical activity. Researchers wanted to see if tracking activity with these devices reduced disease flare-ups better than just getting exercise advice. The trial i…

This study tested whether adding propofol to ketamine sedation reduces agitation when patients wake up after emergency procedures for fractures or dislocations. Researchers compared the two-drug combination against ketamine alone in 150 adults. They measured recovery agitation, s…

This study tested if a specific 6-week muscle-strengthening program could help people with knee osteoarthritis walk better and feel less tired. Researchers compared two different types of exercise in 40 participants to see which was more effective for improving walking distance a…

This study tested whether adding a gentle, needle-free laser treatment to standard anti-nausea medicine could better prevent vomiting and nausea in children and young adults (ages 2-20) undergoing chemotherapy. The laser was aimed at specific acupuncture points on the body. Resea…

This study tested whether using virtual reality (VR) could help reduce pain and anxiety for elderly patients during routine hospital care. Researchers worked with 87 people over 60 years old, letting them choose relaxing VR scenes to watch during procedures. The goal was to see i…

This study tested whether stimulating two different brain areas simultaneously could help people with severe, treatment-resistant chronic pain. Researchers implanted electrodes in eight patients to stimulate both the pain-sensing and emotional-processing parts of the brain. The g…

This study tested a new way to give sedation medicine during very painful emergency procedures, like setting broken bones or fixing dislocated joints. Researchers used a computer-controlled pump to deliver the sedative propofol more precisely than the usual manual method. The goa…

This small study explored whether hypnosis could help adults with chronic, unexplained itching. Researchers tested if guided mental suggestions could reduce the urge to scratch and improve sleep and quality of life. The goal was to find a new way to manage this frustrating sympto…

This small, completed study used brain scans (fMRI) to look for connections in the brain between controlling fine hand movements and making speech sounds. Researchers scanned 20 healthy, right-handed young adults while they performed hand tasks and silently articulated sounds. Th…

This small study aimed to understand if the Epstein-Barr virus (EBV) plays a role in causing inflammation in painful forms of oral lichen planus, a chronic mouth condition. Researchers enrolled 13 adults with the condition to measure levels of the virus in affected tissue. The go…

This study aimed to understand if a common biological process called autophagy connects osteoporosis (bone weakening) and Alzheimer's disease. Researchers compared bone samples from 82 postmenopausal women undergoing hip replacement surgery—some with osteoporosis, some with Alzhe…

This study aimed to better understand how the body fights COVID-19 by testing a new blood test. Researchers enrolled 950 people, including those with confirmed or suspected COVID-19, their close contacts, and healthy volunteers. The goal was to track the immune response over time…

This study examined whether adding a small amount of epinephrine (adrenaline) to a common abdominal nerve block makes the procedure safer. Researchers compared how much of the numbing medication entered patients' bloodstreams when epinephrine was added versus when it wasn't. The …

This was a laboratory study, not a treatment trial in people. Researchers took blood samples from 20 patients with a recurring autoimmune kidney disease called membranous nephropathy. They tested how several different existing drugs affected immune cells in a lab dish, aiming to …

This study aimed to understand if having bronchiolitis, a common infant lung infection, increases a child's risk of developing asthma. Researchers followed 29 infants who had bronchiolitis, testing their lung function and for allergies over three years. The goal was to gather kno…

This study aimed to find out if the blue light from computer and TV screens can make melasma—a common skin condition causing dark patches on the face—worse. Researchers exposed one half of the face of 12 female participants to simulated blue light for five days, using the other h…

This study looked at whether adding an emergency MRI scan to the standard CT scan changes how doctors treat patients with back injuries from accidents. Researchers followed 150 adults who came to the emergency room with spine trauma and received both scans. The goal was to see if…

This study aimed to understand how different types of tiredness—mental fatigue and muscle fatigue—affect an older person's ability to walk and think at the same time. Researchers tested 66 participants, including younger adults and two groups of older adults, by having them walk …

This study aimed to find early signs in the blood that could predict if a kidney transplant patient's COVID-19 infection would get worse. Researchers followed 52 recently infected kidney transplant patients who had mild-to-moderate symptoms, as these patients are at higher risk. …

This study aimed to understand how the drug venetoclax works in older patients with acute myeloid leukemia (AML) who are receiving standard combination therapy. Researchers measured drug levels in patients' blood during their first treatment cycle to see how it affected cancer ce…

This study aimed to create a detailed cellular map of healthy human airways to better understand respiratory diseases. Researchers collected airway samples from 15 healthy volunteers to analyze individual cells throughout the respiratory system. The goal was to document normal ce…

This study aimed to understand if having arthritis in the fingers (digital osteoarthritis) is linked to more severe or faster-progressing arthritis in the hips or knees. Researchers followed 479 adults aged 40-75 who already had symptomatic hip or knee arthritis. They collected X…

This study aimed to understand why severe gum disease is so common after radiation treatment for head and neck cancers. Researchers followed 25 patients to see if radiation changes the levels of a common virus (Epstein-Barr virus) in the gums. The goal was to gather knowledge to …

This study aimed to understand how Alzheimer's disease affects visual attention and search abilities. Researchers tracked eye movements of 48 participants (including Alzheimer's patients and healthy controls) while they searched for objects on a computer screen and in real-world …

This study looked at patients who received a stem cell transplant for blood cancers. Researchers wanted to see if a common side effect—mouth sores known as oral graft-versus-host disease (GVHD)—could be a simple sign that the new donor cells are actively fighting the leukemia. Th…

This study aimed to understand why some patients with wet age-related macular degeneration don't respond well to standard eye injections. Researchers measured specific proteins in the fluid inside the eyes of 100 patients. The goal was to identify biological markers that might pr…

This study used computer models to find the safest way to place a full set of upper teeth on implants immediately after a patient's jawbone was rebuilt. Researchers compared three different implant layouts in a detailed simulation based on one patient's scans. They found the 'all…

This study aimed to find out if shining specific colors of LED light on skin helps it heal faster. Researchers tested this on 10 healthy volunteers by creating small, controlled wounds on their forearms with a laser and then applying different LED lights. The goal was to measure …

This study aimed to understand the psychological impact of the 2016 Nice terrorist attack on hospital staff, medical students, and healthcare workers. Researchers surveyed 804 people who were either directly involved in the emergency response or worked at the hospitals receiving …

This study aimed to understand how apathy affects different types of fatigue in older adults with mild memory problems. Researchers compared 57 participants with and without apathy, measuring their activity levels, fatigue, and movement patterns. The study involved wearing activi…

This completed pilot study aimed to understand how the immune system might contribute to facioscapulumeral muscular dystrophy type 1 (FSHD1), a genetic muscle-wasting disease. Researchers compared blood inflammation markers in 20 adults with FSHD1 to healthy people to see if spec…

This study aimed to see if measuring a substance called lactate in the blood, right when paramedics arrive, could help predict whether a person's heart will restart after an out-of-hospital cardiac arrest. It involved 77 adults who suffered a cardiac arrest. The goal was to gathe…

This study aimed to understand how allergies develop in the airways by comparing gene activity in cells from the nose and lungs. Researchers collected samples from 44 young adults with and without allergies to see how their cells respond differently. The goal was to learn more ab…

This study aimed to understand how a failing liver might contribute to harmful mineral deposits in blood vessels, a common problem in some diseases. Researchers measured a natural substance in the blood of 38 patients before and after their liver transplant. They wanted to see if…

This study aimed to understand why vitiligo treatments work better on some body areas (like the face) than others (like hands and feet). Researchers collected small skin samples from 20 adults with vitiligo and healthy volunteers to compare the molecular activity in different loc…

This study aimed to understand if the common Epstein-Barr virus (EBV) is involved in causing peri-implantitis, a serious infection that can destroy the bone around dental implants and lead to their loss. Researchers studied 30 adults who already had this implant infection to meas…

This study tested whether a mobile app could reliably monitor adults with Facioscapulohumeral Muscular Dystrophy (FSHD) from their homes. Over 12 months, 70 participants used the app to record videos of exercises and answer questions about pain, fatigue, and daily life. The goal …