Centre Hospitalier Universitaire De Nice

This study tests whether methotrexate, a drug used for other types of arthritis, can slow joint damage in people with severe hand osteoarthritis that hasn't responded to standard treatments. About 170 adults with erosive hand osteoarthritis will receive either methotrexate or a p…

This study tests a new procedure called pulsed-field ablation (PFA) to treat persistent atrial fibrillation (AFib), a common heart rhythm problem. About 60 adults with AFib that lasts more than 7 days will receive PFA to isolate the pulmonary veins. Their heart rhythm will be mon…

This study compares two ways of giving the drug tocilizumab to people with rheumatoid arthritis that is under control. One method uses a fixed dose for everyone, while the other adjusts the dose based on the person's weight. The goal is to see if the simpler fixed dose works just…

This study tests a gentle, non-invasive ear stimulation device to help people over 70 improve swallowing after a stroke. Twenty participants will receive either the active device or a sham (inactive) device alongside standard speech therapy for three weeks. Researchers will measu…

This study will observe 150 adults in the hospital who have a bloodstream infection from a long-term arm catheter. Researchers want to see if having a superficial (surface) vein clot along with the infection leads to worse outcomes, like the infection coming back or spreading. Th…

This study uses computer models to compare custom-made versus standard plates for fixing the upper jaw after surgery. Researchers will analyze stress on the plates and bone, as well as jaw movement, in two different surgical scenarios. The goal is to provide insights that help su…

This study looks at why some people with acute lymphoblastic leukemia (ALL) have severe allergic reactions to the drug asparaginase. Researchers will collect blood cells from 20 patients and test them in the lab to see if certain immune cells (T lymphocytes) become overactive. Th…

This study aims to measure pressure inside the belly and in the belly muscles during surgery to fix a type of hernia called an incisional hernia. Ten adults with hernias of a certain size will have pressure readings taken before, during, and after their operation. The goal is to …