Tiny additive could cut risk in abdominal pain blocks
NCT ID NCT04959123
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether adding diluted epinephrine to the numbing drug ropivacaine during a TAP block (a pain block for abdominal surgery) lowers the peak amount of ropivacaine in the blood. Forty adults having laparoscopic colectomy received either ropivacaine alone or with epinephrine. The goal was to see if epinephrine reduces the risk of drug toxicity. Results may help make this common pain block safer.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ropivacaine with or without epinephrine
- What this could lead to
- If adding epinephrine significantly lowers peak ropivacaine levels, it could lead to safer pain-blocking procedures for abdominal surgeries.
- What could go wrong
- This is a small, completed pharmacokinetic study (40 people) that only measures drug levels, not clinical outcomes. Results may not change practice or apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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40 people
The number who actually took part.
- Started
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Dec 2021
- Finished
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Nov 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults (≥ 18 years) scheduled for laparoscopic colectomy * Physical status score ( American Society of Anesthesiologists) ≤ 3 * Non-obese (Body Mass Index \< 30) * Affiliated with a social security plan * Having signed an informed consent * Normal preoperative electrocardiogram including, but not limited to, a non-extended QTc interval (\< 0.45 s in men and \< 0.47 s in women). Exclusion Criteria: * Presence of a contraindication for local anesthesia (injection site infection, coagulopathy) * Known allergy to local anesthetics * Known renal or hepatic insufficiency * Pregnant or breastfeeding women * Medical or psychiatric condition that makes communication difficult * Chronic use of drugs that interfere with CYP1A2 metabolism of ropivacaine such as fluvoxamine (a potent CYP1A2 inhibitor) * Chronic use of opioids or other treatments for chronic pain * Chronic use of anti-arrhythmic drug(s) or drugs that can prolong the QTc space such as haloperidol, amiodarone, sotalol, etc. * Protected persons defined in the following articles of the public health code: L. 1121-6: persons deprived of liberty by a judicial or administrative decision, persons hospitalized without consent and persons admitted to a health or social institution for purposes other than research; L. 1121-8: adults subject to a legal protection measure or unable to express their consent; L. 1122-1-2: persons in emergency situations who are unable to give prior consent. \- Patients participating in other research involving the human person.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU de nice - Anesthésie Réanimation
Nice, Alpes-Maritimes, 06001, France
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