Centre Hospitalier Universitaire De Nīmes

This study tests whether specially trained case managers can reduce the chance of another psychotic episode in young people (ages 16-30) who have had a first episode. Over 3 years, 256 participants will either get standard care or extra support from a case manager. The goal is to…

This study looks at whether taking acid-reducing medication (PPIs) every day for a year after a throat procedure called POEM is better than only taking it when symptoms appear. The goal is to prevent acid reflux and damage to the food pipe. About 132 adults with achalasia (a swal…

This study tests whether removing the mesentery (a fatty tissue near the intestine) during surgery for Crohn's disease is safe and helps prevent the disease from coming back. About 30 adults with Crohn's who are on biotherapy and need ileocolic surgery will take part. Researchers…

This study looks at a new device called Anchorsure® used during surgery to fix a common condition called pelvic organ prolapse, where organs slip out of place. About 120 women will get the device and be followed for 3 years to see how well it works and if it causes less pain than…

This study looks at whether a simple heart ultrasound measurement (called E' variation) can tell doctors if a patient in shock will benefit from intravenous fluids. Researchers will measure the E' wave before and after giving 500 mL of fluid to 187 emergency department patients. …

This study looks at whether a protein called L-PGDS can be used to diagnose adenomyosis, a condition that causes chronic pelvic pain and heavy periods. Researchers will measure L-PGDS in blood, urine, and tissue samples from 60 women with and without adenomyosis. If successful, t…

This study compares a new rapid DNA tool (MinION) with standard lab tests to identify bacteria and fungi in bone samples from people with diabetic foot infections. The goal is to see if the new method can find more germs and provide results faster, helping doctors choose the righ…

This study looks at whether a team of geriatric specialists can help patients aged 70 and older recover their daily living skills better after colorectal cancer surgery, compared to standard care. About 90 participants will be randomly assigned to either the special geriatric uni…

This study tests whether music therapy, delivered through a device called BeatMove, can help people with blocked leg arteries walk longer without pain. About 54 participants will do a 3-month walking program, with some using music therapy and others a sham device. The goal is to …

This study compares two ways of doing robotic knee replacement: keeping the posterior cruciate ligament versus removing it. About 300 adults having their first robotic knee replacement will be randomly assigned to one of the two methods. The goal is to see which approach helps pe…

This study tests if blocking a specific artery (the inferior mesenteric artery) a few weeks before rectal cancer surgery can help the colon adapt and reduce serious complications like leaks (fistulas). About 30 adults with rectal cancer will receive this artery embolization befor…

This study tests a new device called PEASY that collects urine without sticky adhesives, using a gentle hold around the foreskin. It aims to reduce pain, itching, and discomfort compared to current diapers or sleeves. About 20 uncircumcised men with incontinence will try it in th…

This study tests a 10-week therapy program called SINTYA for young adults aged 16-25 with borderline personality disorder (BPD). The program combines group and individual sessions to help reduce impulsive behaviors and improve emotional control. Researchers will compare impulsivi…

This study compares music therapy using Music Care tablets to a gas mixture (EMONO) for reducing anxiety in 128 people with low back pain undergoing a CT-guided spinal injection. Participants will be randomly assigned to listen to music or inhale the gas during the procedure. The…

This study is testing whether a 12-week therapy program called ECCCLORE is practical and acceptable for people who have both post-traumatic stress disorder (PTSD) and addiction. The program combines skills for managing emotions, stress, and relationships. Researchers will enroll …

This study aims to find out which factors—like physical, psychological, or social—predict whether a person with chronic low back pain will benefit from a multidisciplinary rehabilitation program. Researchers will follow 333 adults with pain lasting at least three months. The goal…

This study compares monthly blood tests for a nerve damage marker (NfL) against standard yearly MRI scans in people with relapsing-remitting MS. The goal is to see if the blood test can catch hidden disease activity sooner, allowing faster treatment changes. About 84 participants…

This study watches how people with a leg amputation adapt their walking to missing muscles and sensations. Researchers will measure movement and muscle activity in 75 participants while they walk on different surfaces. The goal is to understand these changes so future prosthetics…

This study tests whether a nurse-led program using online questionnaires and phone calls can help cancer patients transition safely from hospital to home. About 50 adults with cancer who own a smartphone or tablet will participate. The goal is to see if this follow-up approach is…

This study looks at how sleep inertia—the grogginess you feel right after waking up—affects attention in people with major depression. Researchers will compare three groups: depressed patients with sleep inertia, depressed patients without it, and healthy controls. Participants w…

This study looks at how cells in the placenta die or clean themselves in women with pregnancy complications like preeclampsia or poor fetal growth. Researchers will compare these processes in 50 pregnant women to find new ways to screen for and manage these risks. The goal is to …

This study looks at how the pelvis and spine line up when children with cerebral palsy (who have limited walking ability) are sitting. The goal is to better understand these positions to help prevent bone and spine problems. About 100 children aged 4 to 17 will have special X-ray…

This study compares two types of continuous dialysis (CVVHD and CVVHDF) in 80 ICU patients with acute kidney injury. The goal is to see if one method removes waste (urea) from the blood as well as the other. Results will help doctors choose the best approach for kidney support in…

This study looks at how a blood transfusion changes heart function in older anemic patients in the emergency room. Researchers will use ultrasound to check the heart before, right after, and 15 minutes after the transfusion. The goal is to see which heart measurements change the …

This study tracks gut bacteria in 25 children (ages 6-17) with juvenile arthritis to see how different treatments—like anti-inflammatories, methotrexate, or biotherapy—change the types and variety of bacteria in their stool. Researchers will also check if those bacterial changes …

This study looks at MRI scans from 120 women with advanced cervical cancer to see if a computer model can predict who will respond well to standard chemoradiotherapy. The goal is to identify women who might need different or stronger treatments early on. Researchers will analyze …

This study tests whether a rapid finger-prick test for C-reactive protein (CRP) can help primary care doctors decide if a feverish child needs emergency care. About 420 children aged 2-9 with fever will be enrolled. The goal is to reduce unnecessary ER visits and streamline care.

This study uses MRI scans to understand why people with schizophrenia hear voices that aren't there. Researchers think a small brain area called the inferior colliculi may fail to filter out internal sounds. 40 participants with schizophrenia will have their brain activity measur…

This study is testing a new lab test called SPHERTEST to see if it can predict whether immunotherapy will work for people with advanced bladder cancer. Researchers will take blood and tumor samples from 32 patients to build a 3D cell model. The goal is to find a way to personaliz…

This study looks at how long-term antibiotics for severe vesicoureteral reflux (a condition where urine flows backward into the kidneys) affect the diversity of gut bacteria in children aged 1 to 3. Researchers will compare the gut microbiota of children on antibiotic prophylaxis…

This study looks at whether working odd hours or having idle time at work makes people more likely to gamble in risky ways. Researchers will interview 25 adults who currently have or have had gambling problems and who have worked in the past year. The goal is to understand the co…

This study is creating and testing a French version of a questionnaire that measures how well people with rheumatoid arthritis stick to their medication. Researchers will enroll 150 adults who have been on a stable dose of methotrexate for at least a month. The goal is to make su…

This study looks at whether gut bacteria and bacterial leakage into the blood and spinal fluid play a role in type 1 narcolepsy, a rare sleep disorder. Researchers will compare 120 people with and without narcolepsy to understand how gut health might trigger the immune system to …