Baylor Research Institute

This study tests a combination of two drugs, abemaciclib and ramucirumab, in people with advanced esophageal or gastroesophageal junction cancer that has spread. The goal is to see if this drug pair is safe and can help control tumor growth. The trial involves 8 participants whos…

This study planned to test whether curcumin, a natural compound found in turmeric, could safely help shrink or eliminate high-grade cervical pre-cancer (CIN3) in women. It was designed for women aged 21 and older with confirmed CIN3. However, the trial was withdrawn before enroll…

This study looks at whether a drug called everolimus can help prevent liver cancer from coming back after a liver transplant. About 336 adults with high-risk liver cancer will receive either everolimus plus tacrolimus or standard drugs. The main goal is to see how long patients l…

This study tests whether pairing brief pulses of vagus nerve stimulation with rehabilitation exercises can help people with spinal cord injuries regain arm and hand function. Twenty adults with chronic cervical spinal cord injury will receive either active stimulation or a sham d…

This study aimed to see if giving plasma from people who recovered from COVID-19 could help hospitalized patients with pneumonia breathe better and need less oxygen. It was designed for adults who had tested positive for COVID-19. However, the study was withdrawn before enrolling…

This study looks at 100 adults on ECMO (a machine that helps breathe) for respiratory failure. It compares a standard blood thinner given through a vein to one given as a shot under the skin. The goal is to see if the shot is as safe and effective at preventing clots and bleeding…

This study tests a weight-loss program designed for people with traumatic brain injury (TBI). About 57 adults with TBI and a BMI of 25 or higher will join a group lifestyle program or a support group. Researchers will track weight, physical activity, and other health measures for…

This study aims to make a proven weight-loss program more accessible for people with traumatic brain injury (TBI) by delivering it via telehealth. About 85 adults with moderate to severe TBI and a BMI of 25 or higher will participate. The program focuses on healthy eating and phy…

This study is for women aged 20-35 who were born without a uterus or had it removed, but still have working ovaries. Doctors will transplant a uterus from a living or deceased donor, then use IVF to help the woman get pregnant. The goal is a live birth via C-section, but recipien…

This study tests a healthy lifestyle program designed for people who have had a stroke. The program focuses on weight loss and increasing physical activity. Researchers will track 65 participants for 12 months to see if the program helps improve their health.

This study aimed to see if using cold saline to inflate a balloon inside the uterus could reduce blood loss after childbirth better than room temperature saline. It was designed for women 18-45 who had just given birth vaginally and had uncontrolled bleeding. However, the study w…

This study tests whether a workshop led by fellow firefighters can help prevent PTSD, depression, anxiety, and alcohol problems in new firefighter trainees. About 480 recruits will take part in either an emotion regulation workshop or a standard education session during their aca…

This study aimed to see if a nerve block (TAP block) given during stomach surgery could lower the amount of strong painkillers (opioids) patients need afterward. It compared two numbing medicines, Bupivacaine and Exparel. However, the study was withdrawn before any participants w…

This study tests four different numbing medicines (lidocaine, bupivacaine, chlorprocaine, and mepivacaine) to see which one causes the least pain when re-injected during Mohs surgery for skin cancer. About 400 adults will rate their pain on a 1-10 scale. The goal is to find the m…

This study tests whether shining a special near-infrared light on the head can boost brain cell activity and help protect the brain in people with early to mid-stage dementia. One hundred participants aged 50-85 will receive light treatments over 8 weeks. Researchers will measure…

This study tests whether corticosteroids can improve swallowing in people with EGJOO, a condition where the esophagus doesn't relax properly, causing food to get stuck. Researchers suspect an allergy may be involved. Twelve adults with confirmed EGJOO will receive the medication,…

This study tests a recovery plan called ERAS in 60 adults getting a kidney from a live donor. The plan includes a pre-surgery drink, Tylenol, gabapentin, numbing medicine during surgery, and early walking. Researchers want to see if it lowers pain and the need for strong painkill…

This study compares two numbing medications to see which one helps hernia surgery patients feel less pain and recover faster. About 128 adults having abdominal wall reconstruction will receive either a standard numbing mix or a newer long-acting drug. The goal is to find which op…

This study tests a short therapy called Brief Prolonged Exposure (Brief PE) to see if it can reduce post-traumatic stress in people who have had a spinal cord injury. About 200 adults in inpatient rehab will either get the therapy or standard care. The goal is to ease PTSD sympto…

This study tests if a new non-opioid painkiller (suzetrigine) works as well as a standard opioid for pain after Mohs skin cancer surgery. About 75 adults having Mohs surgery will receive either suzetrigine or hydrocodone/acetaminophen. The goal is to see if the non-opioid option …

This study tests a new wireless device that sends small electrical pulses to the vagus nerve during physical therapy. The goal is to see if it safely helps people who had a stroke at least a year ago improve movement and feeling in their affected arm and hand. About 42 adults age…

This study tests two procedures—G-POEM (a tube through the mouth to relax the stomach muscle) and a stomach pacemaker (GES)—alone or together in 40 adults with severe gastroparesis (stomach paralysis) that hasn't improved with medication. The goal is to see which approach best re…

This study interviews 15 adults aged 30-70 from Baylor Scott & White Health to learn what stops people from joining cancer prevention research. The goal is to make future studies more inclusive and reach all communities in the USA. No treatment is given—just conversations to gath…

This study is for athletes aged 10-22 who have had a concussion and are cleared to start playing again. Researchers will test a new exercise routine that mimics sports movements to see how the body responds. The goal is to find better ways to decide when it's truly safe to return…

This study looks at how common anesthetics change the way the esophagus moves during a special imaging test called FLIP. Researchers will study 30 adults with swallowing problems caused by conditions like achalasia. The goal is to better understand how these drugs affect esophage…

This study trains students from underrepresented backgrounds to become certified community health workers (CHWs) focused on mental health. The goal is to increase access to care and address social factors affecting mental well-being. Researchers will track job placement and menta…

This study looks at whether a community wellness program at Bonton Farms can improve heart health and quality of life for 300 adults in the Bonton neighborhood. Participants choose their own activities, and researchers track changes in diet, exercise, sleep, and other health meas…

This study aimed to see if taking antibiotics for three days after prostate surgery (HoLEP) lowers the chance of a urinary tract infection. It was designed for men over 40 with an enlarged prostate and no current infection. However, the study was withdrawn before any participants…

This study was designed to find the best way to give tube feedings to people with head and neck cancer who are also getting chemotherapy and radiation. It planned to compare three methods—bolus, gravity drip, and a feeding pump—to see which one helped patients maintain weight and…