Baylor Research Institute

This study follows 225 adults undergoing the Ross procedure, a surgery that replaces a diseased aortic valve with the patient's own pulmonary valve. Researchers will track survival, re-hospitalization, and need for repeat surgeries over 1, 5, and 10 years. The goal is to confirm …

This study tests if a non-surgical shockwave treatment is as safe and effective as surgery for severe calcium buildup in the main leg artery. About 60 people with leg pain or tissue damage will be randomly assigned to either the shockwave procedure or surgery. The goal is to see …

This study tests a healthy lifestyle program that has been adapted for Hispanic/Latino people who have had a stroke. The goal is to help participants lose weight and improve health markers like blood sugar and cholesterol. The program includes home weighing scales and in-person c…

This study tests a weight-loss program delivered via telehealth for people who have had a stroke. About 94 participants with a BMI of 25 or higher will be randomly assigned to either start the program right away or wait 6 months. The goal is to see if the program helps with weigh…

This early-phase trial tests whether combining two drugs, neratinib and ruxolitinib, is safe and can shrink tumors in people with metastatic triple-negative breast cancer that has come back in the chest wall after chemotherapy. About 20 women aged 18 or older will take both pills…

This study tests whether adding a drug called anakinra to standard chemotherapy can help shrink pancreatic tumors before surgery. About 24 adults with pancreatic cancer that can be removed or may become removable will receive the combination. The goal is to see if this approach l…

This early-stage trial tests a new approach for women with metastatic triple-negative breast cancer that has already been treated with standard chemotherapy. The study uses bortezomib first to make cancer cells more vulnerable, then gives pembrolizumab and cisplatin to attack the…

This study tests whether using ultrasound imaging inside blood vessels during minimally invasive leg artery procedures leads to better outcomes for people with peripheral artery disease. About 350 adults with symptoms like leg pain or wounds will take part. The goal is to see if …

This study checks if it is safe to use hearts from donors who have hepatitis C for heart transplants. About 500 people who received such a heart will be followed to see how they do, including survival, organ rejection, and whether the hepatitis C is cured. The goal is to see if u…

This study tests whether hearts from donors with hepatitis C can be safely transplanted into people without the virus. Participants will take antiviral medication (sofosbuvir/velpatasvir) to prevent infection. The goal is to expand the donor pool for heart failure patients awaiti…

This study tests whether tirzepatide, a weight-loss drug, can help eliminate tiny amounts of cancer left after standard treatment in 48 patients with obesity or overweight and a high-risk type of early breast cancer. The goal is to see if weight loss leads to metabolic changes th…

This study compares two ways to guide a procedure that closes off a part of the heart to prevent strokes in people with atrial fibrillation. The standard method uses a probe down the throat (TEE), while the new method uses a probe inside the heart (ICE). The goal is to see if the…

This study tests whether a brief form of exposure therapy, given soon after a serious injury, can prevent posttraumatic stress disorder (PTSD). Researchers will enroll 300 adults admitted to Level I trauma centers. Participants will be randomly assigned to receive the brief thera…

This study tests a cream made from pasteurized human donor milk to treat low blood sugar in newborns at risk. Researchers want to see if the cream can raise and stabilize blood sugar better than current treatments, and if it can reduce the need for intensive care. About 75 newbor…

This study tests whether a robotic exoskeleton can help people walk sooner and more safely after heart or lung surgery. Twenty adults who have had procedures like bypass or valve repair will either use the robot or get standard physical therapy. The goal is to see if the robot ma…

This study compares robotic gait training to usual physical therapy for people recovering from a stroke. Researchers want to see if using a robotic exoskeleton early in rehab helps patients walk faster and more independently. The study involves 54 adults aged 18-85 who are in inp…

This study tests a shockwave technique (intravascular lithotripsy) to break up heavy calcium buildup in the iliac arteries of 50 people with severe aortic stenosis. The goal is to make room for a new heart valve to be delivered through a leg artery, avoiding more invasive approac…

This study looks at how the bacteria in your gut and what you eat might influence diarrhea caused by chemotherapy in people with colon cancer. Researchers will collect stool samples and diet surveys from 11 participants before and during treatment. The goal is to find patterns th…

This study collects blood and tissue samples from 100 adults who have had a lung transplant in the last 10 years. Researchers will use these samples to study biomarkers and how infections affect outcomes. The goal is to improve care for people with advanced lung disease, not to t…

This study looks at whether doing intense exercise before a blood test can make the test better at finding early signs of heart transplant rejection. Researchers will test 27 heart transplant recipients. The goal is to see if exercise changes the levels of DNA from the donor hear…

This study looks at the bacteria (microbiome) involved in leaks from the esophagus or stomach. Researchers want to understand how these germs change over time and how the body responds, so they can find better ways to help patients heal. About 50 adults with such leaks will provi…

This study looks at how well transplanted insulin-making cells (islets) work in people with chronic pancreatitis who have their pancreas removed. Researchers will collect blood samples to measure inflammation and graft function. The goal is to understand what affects long-term su…

This study is watching 14,000 people with peripheral artery disease (PAD) to see how well stents work compared to treatments without stents. Researchers will track things like repeat procedures, amputations, and walking ability for one year. The goal is to learn which approach wo…

This study looks at how small heart blood vessels work in people who have chest pain but no major blockages. Researchers will give a nitrate medicine and measure blood flow before and after. The goal is to better understand these conditions, not to treat them directly.

This study aims to collect and store blood, tissue, urine, and stool samples from up to 10,000 cancer patients across Texas. Researchers will use these samples to study how the immune system responds to cancer treatments and find markers that predict which therapies work best. Th…