SYSTEMIC SCLEROSIS (SSC)

This study is testing a live attenuated dengue vaccine (Butantan-DV) in 477 people aged 12–59 with stable autoimmune rheumatic diseases (like rheumatoid arthritis or lupus) and in healthy volunteers. The goal is to see if the vaccine is safe and produces a strong immune response …

This early-phase study tests a new treatment using specially engineered immune cells (CAR-T) in 11 children with severe rheumatic diseases like juvenile dermatomyositis and arthritis that haven't responded to standard therapies. The goal is to see if the treatment is safe and can…

This early-stage study tests the safety of a new drug called CC312 in 18 adults with autoimmune diseases like lupus, rheumatoid arthritis, and scleroderma that have not responded to standard treatments. CC312 works by helping the body's immune cells find and attack faulty B cells…

This early-stage trial tests whether a patient's own immune cells, modified to target CD19, can safely treat severe systemic sclerosis (scleroderma) that hasn't responded to standard drugs. About 12 children and adults will receive the CAR-T infusion and be monitored for changes …

This early-stage trial tests a new treatment called FT819 for people with certain autoimmune diseases like lupus, vasculitis, myositis, and scleroderma. The treatment aims to target and control the immune cells that cause these diseases. The study will check if FT819 is safe and …

This study tests an investigational drug called efgartigimod in 81 adults with systemic sclerosis, a disease that causes skin thickening and organ damage. Participants receive either the drug or a placebo for up to 48 weeks. The main goal is to see if the drug improves skin thick…

This study tests whether artificial intelligence (AI) can better detect a serious lung condition called pulmonary arterial hypertension (PAH) in people with scleroderma. PAH often goes unnoticed until it's advanced, but AI may help catch it earlier using simple tests like EKGs an…

This study tests whether a person's own fat-derived cells can improve hand function in systemic sclerosis (scleroderma). About 48 adults with hand stiffness will either get injections of these cells into their fingers or receive standard care. The main goal is to see if hand move…

This study tests whether a lotion made with hemp extract (CBD) and urea can relieve itching, improve skin moisture, and help sleep in people with scleroderma. About 36 adults with chronic itching will use either the CBD lotion or a plain urea lotion, then switch after a period. T…

This study tests a biopsychosocial exercise program called BETY in 48 children and adults with scleroderma. The goal is to see if it improves movement, skin health, and overall well-being. Participants are randomly assigned to BETY or usual care, and outcomes are measured over ti…

This study looks at how nutrition is linked to disease activity in people with rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will measure the nutritional status of 460 participants using blood tests and questionnaires. The goal is to un…

This study aims to find out if certain substances in the blood, called interferons, can predict serious side effects from cancer immunotherapy. Researchers will collect blood samples from 300 cancer patients starting immunotherapy and 40 people with autoimmune diseases like lupus…