SYSTEMIC SCLEROSIS (SSC)

This study is testing a live attenuated dengue vaccine (Butantan-DV) in 477 people aged 12–59 with stable autoimmune rheumatic diseases (like rheumatoid arthritis or lupus) and in healthy volunteers. The goal is to see if the vaccine is safe and produces a strong immune response …

This early-stage trial tests a new treatment called FT819 for people with certain autoimmune diseases like lupus, vasculitis, myositis, and scleroderma. The treatment aims to target and control the immune cells that cause these diseases. The study will check if FT819 is safe and …

This study tests an investigational drug called efgartigimod in 81 adults with systemic sclerosis, a disease that causes skin thickening and organ damage. Participants receive either the drug or a placebo for up to 48 weeks. The main goal is to see if the drug improves skin thick…

This study tests whether artificial intelligence (AI) can better detect a serious lung condition called pulmonary arterial hypertension (PAH) in people with scleroderma. PAH often goes unnoticed until it's advanced, but AI may help catch it earlier using simple tests like EKGs an…

This study tests a biopsychosocial exercise program called BETY in 48 children and adults with scleroderma. The goal is to see if it improves movement, skin health, and overall well-being. Participants are randomly assigned to BETY or usual care, and outcomes are measured over ti…

This study tests whether a lotion made with hemp extract (CBD) and urea can relieve itching in people with scleroderma, a condition that causes skin hardening and often severe itch. About 36 adults with scleroderma and chronic itching will use either the CBD lotion or a plain ure…