SYSTEMIC SCLEROSIS (SSC)

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, or scleroderma that haven't improved with standard treatments. Only 6 adults aged 18-…

This early-stage trial tests a new stem cell injection made from umbilical cord cells for people with systemic sclerosis, a rare disease that causes skin hardening and organ damage. About 21 adults with recent-onset diffuse disease will receive the treatment to check its safety a…

This early-stage study tests a new drug, cizutamig, in 10 people with systemic sclerosis, a disease that causes skin and organ hardening. The main goal is to check safety and how the body handles the drug. Researchers will also look for early signs that the drug might help contro…

This early study tests BCT301, a therapy made from specially grown stem cells that become immune cells designed to attack faulty B cells. It aims to see if it is safe and tolerable for 10 people with severe autoimmune diseases like lupus, scleroderma, and vasculitis. The main goa…

This early-stage study tests a new treatment called HN2302 in 12 adults with lupus or scleroderma. The therapy aims to reprogram the body's immune cells to attack faulty cells causing the disease. The main goal is to check safety, while also seeing if it reduces symptoms.

This early-phase study tests a new drug called GB261 in 10 adults with systemic sclerosis, a disease that causes skin hardening and organ damage. The main goal is to check safety and how the body handles the drug. It is not a cure but aims to control the disease.

This study uses blood and skin samples from 10 people with early, severe systemic sclerosis and 10 healthy volunteers to see if blocking a protein called TL1A can stop or reverse skin scarring. Researchers will test this in the lab, not on patients directly. The goal is to unders…

This study will use a high-tech blood test (mass spectrometry) to look at different immune cells in 500 people with various autoimmune diseases like lupus, rheumatoid arthritis, and Sjogren's syndrome, plus healthy volunteers. The goal is to find patterns that could help doctors …

This study looks at a blood protein called FAP, which is linked to tissue scarring and inflammation. Researchers will measure FAP levels in people with rheumatoid arthritis, systemic sclerosis, and healthy volunteers. The goal is to see if FAP levels relate to disease activity an…